Ebook: Model Systems in Aging
Author: Thomas Nyström (auth.)
- Tags: Cell Biology, Biomedicine general, Developmental Biology
- Series: Topics in Current Genetics 3
- Year: 2004
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
Aging is the progressive decline in biological functions over time. This decline targets macromolecules, cells, tissues and, as a consequence, whole organisms. Despite considerable progress in the development of testable hypothesis concerning aging in an evolutionary context, a unifying theory of the molecular/physiological mechanistic causes of aging has not been reached. In fact, is it not clear to what extent aging is a programmed or stochastic process.
This book takes the reader from unicellular bacterial deterioration via senescence in yeast and worms to aging in rodents and humans, allowing a comparative view on similarities and differences in different genetic model systems. The different model systems are scrutinized in the light of contemporary aging hypothesis, such as the free radical and genomic instability theories.
Aging is the progressive decline in biological functions over time. This decline targets macromolecules, cells, tissues and, as a consequence, whole organisms. Despite considerable progress in the development of testable hypothesis concerning aging in an evolutionary context, a unifying theory of the molecular/physiological mechanistic causes of aging has not been reached. In fact, is it not clear to what extent aging is a programmed or stochastic process.
This book takes the reader from unicellular bacterial deterioration via senescence in yeast and worms to aging in rodents and humans, allowing a comparative view on similarities and differences in different genetic model systems. The different model systems are scrutinized in the light of contemporary aging hypothesis, such as the free radical and genomic instability theories.
Aging is the progressive decline in biological functions over time. This decline targets macromolecules, cells, tissues and, as a consequence, whole organisms. Despite considerable progress in the development of testable hypothesis concerning aging in an evolutionary context, a unifying theory of the molecular/physiological mechanistic causes of aging has not been reached. In fact, is it not clear to what extent aging is a programmed or stochastic process.
This book takes the reader from unicellular bacterial deterioration via senescence in yeast and worms to aging in rodents and humans, allowing a comparative view on similarities and differences in different genetic model systems. The different model systems are scrutinized in the light of contemporary aging hypothesis, such as the free radical and genomic instability theories.
Content:
Conditional senescence in prokaryotes....Pages 1-16
Aging and mitochondrial dysfunction in the filamentous fungus Podospora anserina ....Pages 17-38
Mitochondria, metabolism, and aging in yeast....Pages 39-59
Yeast as a model for ageing and apoptosis research....Pages 61-97
Energy metabolism, anti-oxidant defense and aging in Caenorhabditis elegans ....Pages 99-144
Do green plants age, and if so, how?....Pages 145-171
Mammalian and bird aging, oxygen radicals, and restricted feeding....Pages 173-189
Aging and the programmed death phenomena....Pages 191-238
The human Werner Syndrome as a model system for aging....Pages 239-268
Role of subcytotoxic stress in tissue ageing....Pages 269-294