Ebook: Myb Transcription Factors: Their Role in Growth, Differentiation and Disease
- Tags: Biomedicine general, Cancer Research, Hematology, Proteomics, Cell Biology, Developmental Biology
- Series: Proteins and Cell Regulation 2
- Year: 2004
- Publisher: Springer Netherlands
- Edition: 1
- Language: English
- pdf
This volume represents the first collection of articles contributed by research leaders working on the Myb family of transcriptional regulatory proteins. In more than twenty chapters the authors discuss the range of biological processes and diverse cell types in which Myb proteins operate. Although concentrating on the three vertebrate Myb family members, homologues from lower species are also discussed because of the light they are able to shed on the evolution and function of these proteins. Individual chapters describe the involvement of Myb proteins, in particular c-Myb, in normal and diseased development and function of many tissues including haemopoietic cells, blood vessels, the gastrointestinal tract and the brain. Several chapters explore the mechanistic details of the action of Myb proteins, especially structural features, their interaction with DNA and other regulatory proteins, and the variety of genes that are regulatory targets for this group of transcription factors. This work will be of interest to those working directly in the field and also to the wider research community investigating the transcriptional regulation of development, differentiation and growth. The therapeutic potential of manipulating Myb function is also discussed making the book appealing to clinician scientists in several fields including haematology, oncology and cardiology.
This volume represents the first collection of articles contributed by research leaders working on the Myb family of transcriptional regulatory proteins. In more than twenty chapters the authors discuss the range of biological processes and diverse cell types in which Myb proteins operate. Although concentrating on the three vertebrate Myb family members, homologues from lower species are also discussed because of the light they are able to shed on the evolution and function of these proteins. Individual chapters describe the involvement of Myb proteins, in particular c-Myb, in normal and diseased development and function of many tissues including haemopoietic cells, blood vessels, the gastrointestinal tract and the brain. Several chapters explore the mechanistic details of the action of Myb proteins, especially structural features, their interaction with DNA and other regulatory proteins, and the variety of genes that are regulatory targets for this group of transcription factors. This work will be of interest to those working directly in the field and also to the wider research community investigating the transcriptional regulation of development, differentiation and growth. The therapeutic potential of manipulating Myb function is also discussed making the book appealing to clinician scientists in several fields including haematology, oncology and cardiology.
This volume represents the first collection of articles contributed by research leaders working on the Myb family of transcriptional regulatory proteins. In more than twenty chapters the authors discuss the range of biological processes and diverse cell types in which Myb proteins operate. Although concentrating on the three vertebrate Myb family members, homologues from lower species are also discussed because of the light they are able to shed on the evolution and function of these proteins. Individual chapters describe the involvement of Myb proteins, in particular c-Myb, in normal and diseased development and function of many tissues including haemopoietic cells, blood vessels, the gastrointestinal tract and the brain. Several chapters explore the mechanistic details of the action of Myb proteins, especially structural features, their interaction with DNA and other regulatory proteins, and the variety of genes that are regulatory targets for this group of transcription factors. This work will be of interest to those working directly in the field and also to the wider research community investigating the transcriptional regulation of development, differentiation and growth. The therapeutic potential of manipulating Myb function is also discussed making the book appealing to clinician scientists in several fields including haematology, oncology and cardiology.
Content:
Front Matter....Pages i-xxxi
Evolution of Myb Proteins....Pages 1-33
Drosophila Myb....Pages 35-64
Essential And Diverse Roles For C-Myb Throughout T Cell Development....Pages 65-80
Potential Roles For C-Myb Thoughout Early Lymphocyte Development....Pages 81-105
Involvement Of C-Myb In Red Cell And Megakaryocyte Development....Pages 107-131
C-Myb As A Key Player In The Control Of Myeloid Cell Differentiation....Pages 133-144
Does C-Myb Have A Role In Haemopoietic Stem Cells And Multilineage Progenitors?....Pages 145-161
A-Myb In Development And Cancer....Pages 163-179
B-Myb: A Highly Regulated Member Of The Myb Transcription Factor Family....Pages 181-199
Regulation Of Mammalian Myb Gene Expression....Pages 201-221
The C-Myb Dna Binding Domain....Pages 223-238
Myb Partnerships....Pages 239-256
Target Genes Of V-Myb And C-Myb....Pages 257-270
The Microarray Big Bang....Pages 271-278
The V-Myb Oncogene....Pages 279-306
C-Myb And Leukaemogenesis....Pages 307-329
The Involvement Of Myb In Vascular Injury....Pages 331-349
Repression Of Matrix Gene Expression By B-Myb....Pages 351-366
The Role Of C-Myb In Gastrointestinal Tract Development And Carcinogenesis....Pages 367-388
C-Myb And Creb Function In Adult Neurogenesis....Pages 389-397
The C-Myb Gene: A Rational Target For Treatment Of Human Diseases....Pages 399-415