Ebook: Trends in Stem Cell Proliferation and Cancer Research

The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

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The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

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The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance
Content:
Front Matter....Pages i-xviii
Front Matter....Pages 1-1
An Introduction to Proliferation and Migration of Stem and Cancer Cells....Pages 3-12
The Role of Cell Adhesion, Cell Junctions, and Extracellular Matrix in Development and Carcinogenesis....Pages 13-49
The Embryonic Rest Hypothesis of Cancer Development: 150 Years Later....Pages 51-63
Are Calcium Channels More Important Than Calcium Influx for Cell Proliferation?....Pages 65-92
Role of Calcium Signaling in Stem and Cancer Cell Proliferation ....Pages 93-137
Formation and Function of Lipid Droplets in Inflammation and Cancer....Pages 139-165
The Role of Sphingolipids in Modulating Pluripotency of Stem Cells ....Pages 167-191
Front Matter....Pages 193-193
Signaling Pathways of Cbl-b and Its Role in Peripheral T Cell Tolerance....Pages 195-203
BH3-Only Proteins in Cancer and Apoptosis....Pages 205-249
Signaling Pathways of MTA Family Proteins as Regulators of Cancer Progression and Metastasis....Pages 251-275
Signalling Pathways of β-Catenin/JNK in Carcinogenesis....Pages 277-296
The Regulation of the JNK Cascade and Programmed Cell Death by NF-κB: Mechanisms and Functions....Pages 297-336
Front Matter....Pages 337-337
Migration, Metastasis, and More: The Role of Chemokines in the Proliferation, Spreading, and Metastasis of Tumors....Pages 339-358
Autophagy, Cell Death, and Cancer....Pages 359-390
The Duality of Stem Cells: Double-Edged Sword in tumor Evolution and Treatment....Pages 391-433
Implications of Glioblastoma Stem Cells in Chemoresistance ....Pages 435-462
The Tumor Microenvironment as a Transient Niche: A Modulator of Epigenetic States and Stem Cell Functions....Pages 463-478
Tumor-Associated Neutrophils ....Pages 479-501
MicroRNA Control of Apoptotic Programs in Cancer....Pages 503-530
Front Matter....Pages 531-532
Markers of Cancer Stem Cells and Their Functions....Pages 533-558
Front Matter....Pages 531-532
Cancer Cell Dormancy: Potential Therapeutic Targets To Eradicate Cancer Cells Within the Niche....Pages 559-571
Modulating Apoptosis in Cancer Therapy with Ultrasound and High-Intensity Nanosecond Electric Pulses....Pages 573-590
Targeting the Cell Cycle for Cancer Treatment and Neuroprotection....Pages 591-654
Back Matter....Pages 655-661