Ebook: Bioinformatics and Functional Genomics, Second Edition

Widely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research.

This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:

• Several fundamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to basic biological questions.
• A completely updated companion web site, which will be updated as new information becomes available - visit www.wiley.com/go/pevsnerbioinformatics
• Descriptions of genome sequencing projects spanning the tree of life.
• A stronger focus on how bioinformatics tools are used to understand human disease.

The book is complemented by lavish illustrations and more than 500 figures and tables—fifty of which are entirely new to this edition. Each chapter includes a Problem Set, Pitfalls, Boxes explaining key techniques and mathematics/statistics principles, Summary, Recommended Reading, and a list of freely available software. Readers may visit a related Web page for supplemental information at www.wiley.com/go/pevsnerbioinformatics.

Bioinformatics and Functional Genomics, Second Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

Praise for the first edition:

"...ideal both for biologists who want to master the application of bioinformatics to real-world problems and for computer scientists who need to understand the biological questions that motivate algorithms." Quarterly Review of Biology

"… an excellent textbook for graduate students and upper level undergraduate students." Annals of Biomedical Engineering

"…highly recommended for academic and medical libraries, and for researchers as an introduction and reference…" E-StreamsContent:
Chapter 1 Introduction (pages 3–11):
Chapter 2 Access to Sequence Data and Literature Information (pages 12–45):
Chapter 3 Pairwise Sequence Alignment (pages 46–98):
Chapter 4 Basic Local Alignment Search Tool (BLAST) (pages 100–138):
Chapter 5 Advanced Database Searching (pages 140–177):
Chapter 6 Multiple Sequence Alignment (pages 178–212):
Chapter 7 Molecular Phylogeny and Evolution (pages 214–275):
Chapter 8 Bioinformatic Approaches to Ribonucleic Acid (RNA) (pages 279–328):
Chapter 9 Gene Expression: Microarray Data Analysis (pages 330–376):
Chapter 10 Protein Analysis and Proteomics (pages 378–418):
Chapter 11 Protein Structure (pages 420–459):
Chapter 12 Functional Genomics (pages 460–514):
Chapter 13 Completed Genomes (pages 517–565):
Chapter 14 Completed Genomes: Viruses (pages 566–595):
Chapter 15 Completed Genomes: Bacteria and Archaea (pages 596–636):
Chapter 16 The Eukaryotic Chromosome (pages 638–695):
Chapter 17 Eukaryotic Genomes: Fungi (pages 696–726):
Chapter 18 Eukaryotic Genomes: From Parasites to Primates (pages 728–788):
Chapter 19 Human Genome (pages 790–836):
Chapter 20 Human Disease (pages 838–889):