Ebook: Myelodysplastic Syndromes

The diagnosis of myelodysplastic syndromes (MDS), a heterogeneous group of clonal hematopoietic disorders, is being made with increasing frequency over the past decade owing to increased recognition, improved understanding, and an aging population. This book, completely updated since the first edition, summarizes in a concise and focused way the current knowledge of all aspects of MDS. Clinical presentation, etiology, epidemiology, molecular biology, classification, and staging are all discussed. Clear guidance is provided on diagnosis and differential diagnosis, and treatment strategies are explained in detail, including administration of hematopoietic growth factors, biologically based treatment, hematopoietic stem cell transplantation, and supportive care. Additional chapter is devoted to MDS in children. This practically oriented book will be of value to a broad spectrum of students and practitioners in the field.

Myelodysplastic syndromes (MDS) have been studied intensively in recent years and knowledge of the disease process and underlying molecular defects in MDS has expanded rapidly. With the aging of populations and the concurrent increase in the diagnosis of MDS, these findings are of central clinical importance. New prognostic classification systems with refined prognostic significance have been developed, and molecular abnormalities are now finding their way into the process of clinical decision-making. The book has been completely updated since the first edition and concisely summarizes the state of the art on all aspects of MDS, including clinical presentation, etiology, epidemiology, molecular biology, classification, and staging. The different chapters provide guidance on diagnosis and differential diagnosis, as well as on treatment strategies, including the use of hematopoietic growth factors, biology-based treatment, hematopoietic stem cell transplantation, and supportive care. MDS in children is also addressed in a separate chapter. This practically oriented book will be a valuable resource for a broad range of students and practitioners in the field.

Myelodysplastic syndromes (MDS) have been studied intensively in recent years and knowledge of the disease process and underlying molecular defects in MDS has expanded rapidly. With the aging of populations and the concurrent increase in the diagnosis of MDS, these findings are of central clinical importance. New prognostic classification systems with refined prognostic significance have been developed, and molecular abnormalities are now finding their way into the process of clinical decision-making. The book has been completely updated since the first edition and concisely summarizes the state of the art on all aspects of MDS, including clinical presentation, etiology, epidemiology, molecular biology, classification, and staging. The different chapters provide guidance on diagnosis and differential diagnosis, as well as on treatment strategies, including the use of hematopoietic growth factors, biology-based treatment, hematopoietic stem cell transplantation, and supportive care. MDS in children is also addressed in a separate chapter. This practically oriented book will be a valuable resource for a broad range of students and practitioners in the field.

Content:
Front Matter....Pages i-viii
Front Matter....Pages 1-1
Clinical Presentation and Differential Diagnosis....Pages 3-8
Epidemiology and Etiology....Pages 9-38
Front Matter....Pages 39-39
Cytogenetic Diagnosis of Myelodysplastic Syndromes....Pages 41-72
MDS Stem Cell Biology....Pages 73-84
The Biology of Myelodysplastic Syndrome Associated with Isolated del(5q)....Pages 85-95
A Personalized Molecular Pathogenesis of MDS....Pages 97-109
Myelodysplastic/Myeloproliferative Neoplasms....Pages 111-126
Classification and Staging of Myelodysplastic Syndromes....Pages 127-139
Immunophenotyping in Myelodysplastic Syndromes....Pages 141-152
Prognostic Models for Patients with Myelodysplastic Syndromes....Pages 153-167
Front Matter....Pages 169-169
Management of Low-Risk MDS....Pages 171-187
Management of High-Risk Myelodysplastic Syndrome....Pages 189-210
Hematopoietic Cell Transplantation (HCT)....Pages 211-228
Front Matter....Pages 229-229
Myelodysplastic Syndrome in Children....Pages 231-240
Back Matter....Pages 241-245

Myelodysplastic syndromes (MDS) have been studied intensively in recent years and knowledge of the disease process and underlying molecular defects in MDS has expanded rapidly. With the aging of populations and the concurrent increase in the diagnosis of MDS, these findings are of central clinical importance. New prognostic classification systems with refined prognostic significance have been developed, and molecular abnormalities are now finding their way into the process of clinical decision-making. The book has been completely updated since the first edition and concisely summarizes the state of the art on all aspects of MDS, including clinical presentation, etiology, epidemiology, molecular biology, classification, and staging. The different chapters provide guidance on diagnosis and differential diagnosis, as well as on treatment strategies, including the use of hematopoietic growth factors, biology-based treatment, hematopoietic stem cell transplantation, and supportive care. MDS in children is also addressed in a separate chapter. This practically oriented book will be a valuable resource for a broad range of students and practitioners in the field.

Content:
Front Matter....Pages i-viii
Front Matter....Pages 1-1
Clinical Presentation and Differential Diagnosis....Pages 3-8
Epidemiology and Etiology....Pages 9-38
Front Matter....Pages 39-39
Cytogenetic Diagnosis of Myelodysplastic Syndromes....Pages 41-72
MDS Stem Cell Biology....Pages 73-84
The Biology of Myelodysplastic Syndrome Associated with Isolated del(5q)....Pages 85-95
A Personalized Molecular Pathogenesis of MDS....Pages 97-109
Myelodysplastic/Myeloproliferative Neoplasms....Pages 111-126
Classification and Staging of Myelodysplastic Syndromes....Pages 127-139
Immunophenotyping in Myelodysplastic Syndromes....Pages 141-152
Prognostic Models for Patients with Myelodysplastic Syndromes....Pages 153-167
Front Matter....Pages 169-169
Management of Low-Risk MDS....Pages 171-187
Management of High-Risk Myelodysplastic Syndrome....Pages 189-210
Hematopoietic Cell Transplantation (HCT)....Pages 211-228
Front Matter....Pages 229-229
Myelodysplastic Syndrome in Children....Pages 231-240
Back Matter....Pages 241-245
....