Ebook: Pharmacology of Endogenous Neurotoxins: A Handbook
- Tags: Pharmacology/Toxicology, Neurology, Science general, Medicine/Public Health general
- Year: 1998
- Publisher: Birkhäuser Basel
- Edition: 1
- Language: English
- pdf
It is a great pleasure to write the foreword to this important volume for several reasons. First: As far as we know, already primitive societies had to cope with environmental toxins of many kinds and set up regulations to limit their effects on food and drug use. Modem science, synthesizing tens of millions of new compounds has incredibly magnified this challenge. Today, xenobiotic metabolism has become a crucial task for humans and many other species alike. Second: When reading this book, one is impressed by the extraordinary speed at which neurotoxicology has advanced. Obviously, processing (and endogenous formation) oftox ins has become an extremely relevant topic. When I had the chance, almost three decades ago, to work in chemical pharmacology with Bernard B. Brodie at NIH, the drug metabo lizing system of the liver had just been recognized and characterized. We had just started to work on the biogenic amines, newly discovered cyclic nucleotides in rat brain, human cere brospinal fluid, and on the effects of toxic drugs like amphetamines. Today, biochemical neuropharmacology is a mature field of neuroscience.
Content:
Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Isoquinoline Derivatives....Pages 3-23
TIQ Derivatives in the Human Central Nervous System....Pages 25-40
An Animal Model of Parkinson’s Disease Prepared by Endogenous N -Methyl(R)Salsolinol....Pages 41-61
Putative Endogenous Neurotoxins Derived from the Biogenic Amine Neurotransmitters....Pages 63-128
?-Carboline Derivatives as Neurotoxins....Pages 129-149
Highly Halogenated Tetrahydro-?-Carbolines as a New Class of Dopaminergic Neurotoxins....Pages 151-169
pros-Methylimidazoleacetic Acid: A Potential Neurotoxin in Brain?....Pages 171-187
Front Matter....Pages 189-189
Bioactivation of Azaheterocyclic Amines via S-Adenosyl-L-Methionine-Dependent N-Methyltransferases....Pages 191-208
Tyrosine Hydroxylase: Biochemical Properties and Short-term Regulation in vitro and in vivo....Pages 209-220
Tyrosine Hydroxylase and Endogenous Neurotoxins....Pages 221-236
Monoamine Oxidase: Interaction with Isoquinoline Derivatives....Pages 237-252
Toxicity and Pharmacological Effects of Salsolinol in Different Cultivated Cells....Pages 253-266
Back Matter....Pages 267-273
Content:
Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Isoquinoline Derivatives....Pages 3-23
TIQ Derivatives in the Human Central Nervous System....Pages 25-40
An Animal Model of Parkinson’s Disease Prepared by Endogenous N -Methyl(R)Salsolinol....Pages 41-61
Putative Endogenous Neurotoxins Derived from the Biogenic Amine Neurotransmitters....Pages 63-128
?-Carboline Derivatives as Neurotoxins....Pages 129-149
Highly Halogenated Tetrahydro-?-Carbolines as a New Class of Dopaminergic Neurotoxins....Pages 151-169
pros-Methylimidazoleacetic Acid: A Potential Neurotoxin in Brain?....Pages 171-187
Front Matter....Pages 189-189
Bioactivation of Azaheterocyclic Amines via S-Adenosyl-L-Methionine-Dependent N-Methyltransferases....Pages 191-208
Tyrosine Hydroxylase: Biochemical Properties and Short-term Regulation in vitro and in vivo....Pages 209-220
Tyrosine Hydroxylase and Endogenous Neurotoxins....Pages 221-236
Monoamine Oxidase: Interaction with Isoquinoline Derivatives....Pages 237-252
Toxicity and Pharmacological Effects of Salsolinol in Different Cultivated Cells....Pages 253-266
Back Matter....Pages 267-273
....