Ebook: Prions and Diseases: Volume 2, Animals, Humans and the Environment

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

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Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrP^Sc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

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Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrP^Sc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

Content:
Front Matter....Pages i-ix
Bovine Spongiform Encephalopathy....Pages 1-13
Classical and Atypical Scrapie in Sheep and Goats....Pages 15-44
Chronic Wasting Disease and the Development of Research Models....Pages 45-57
Human Sporadic Prion Diseases....Pages 59-72
Environmentally Acquired Transmissible Spongiform Encephalopathy....Pages 73-88
Prions in the Environment....Pages 89-101
The Spectrum of Tau Pathology in Human Prion Disease....Pages 103-119
Risk of Transmission of Creutzfeldt–Jakob Disease by Blood Transfusion....Pages 121-138
Species Barriers in Prion Disease....Pages 139-154
Transgenic Mice Modelling....Pages 155-169
Transgenic Mouse Models in Prion Transmission Studies....Pages 171-182
Alternative Models of Prion Diseases....Pages 183-199
Diagnosis of Prion Disease: Conventional Approaches....Pages 201-222
Quaking-Induced Conversion Assays for the Detection and Diagnosis of Prion Diseases....Pages 223-232
The Tyr-Tyr-Arg Prion-Specific Epitope: Update and Context....Pages 233-255
Overview on Treatment of Prion Diseases and Decontamination of Prions....Pages 257-267
Immunomodulation....Pages 269-287
Back Matter....Pages 289-295

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Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrP^Sc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

Content:
Front Matter....Pages i-ix
Bovine Spongiform Encephalopathy....Pages 1-13
Classical and Atypical Scrapie in Sheep and Goats....Pages 15-44
Chronic Wasting Disease and the Development of Research Models....Pages 45-57
Human Sporadic Prion Diseases....Pages 59-72
Environmentally Acquired Transmissible Spongiform Encephalopathy....Pages 73-88
Prions in the Environment....Pages 89-101
The Spectrum of Tau Pathology in Human Prion Disease....Pages 103-119
Risk of Transmission of Creutzfeldt–Jakob Disease by Blood Transfusion....Pages 121-138
Species Barriers in Prion Disease....Pages 139-154
Transgenic Mice Modelling....Pages 155-169
Transgenic Mouse Models in Prion Transmission Studies....Pages 171-182
Alternative Models of Prion Diseases....Pages 183-199
Diagnosis of Prion Disease: Conventional Approaches....Pages 201-222
Quaking-Induced Conversion Assays for the Detection and Diagnosis of Prion Diseases....Pages 223-232
The Tyr-Tyr-Arg Prion-Specific Epitope: Update and Context....Pages 233-255
Overview on Treatment of Prion Diseases and Decontamination of Prions....Pages 257-267
Immunomodulation....Pages 269-287
Back Matter....Pages 289-295
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