Ebook: Epigenetics: Development and Disease

Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies. This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.

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Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions.

This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies.

This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.

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Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions.

This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies.

This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.

Content:
Front Matter....Pages i-xxvi
Front Matter....Pages 1-1
Chromatin Organization, Epigenetics and Differentiation: An Evolutionary Perspective....Pages 3-35
Secondary Structures of the Core Histone N-terminal Tails: Their Role in Regulating Chromatin Structure....Pages 37-55
Megabase Replication Domains Along the Human Genome: Relation to Chromatin Structure and Genome Organisation....Pages 57-80
Role of DNA Methyltransferases in Epigenetic Regulation in Bacteria....Pages 81-102
Front Matter....Pages 103-103
Metabolic Aspects of Epigenome: Coupling of S-Adenosylmethionine Synthesis and Gene Regulation on Chromatin by SAMIT Module....Pages 105-118
Epigenetic Regulation of Male Germ Cell Differentiation....Pages 119-138
Epigenetic Regulation of Skeletal Muscle Development and Differentiation....Pages 139-150
Small Changes, Big Effects: Chromatin Goes Aging....Pages 151-176
Homeotic Gene Regulation: A Paradigm for Epigenetic Mechanisms Underlying Organismal Development....Pages 177-207
Front Matter....Pages 209-209
Basic Mechanisms in RNA Polymerase I Transcription of the Ribosomal RNA Genes....Pages 211-236
The RNA Polymerase II Transcriptional Machinery and Its Epigenetic Context....Pages 237-259
RNA Polymerase III Transcription – Regulated by Chromatin Structure and Regulator of Nuclear Chromatin Organization....Pages 261-287
The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in Humans....Pages 289-317
Histone Variants and Transcription Regulation....Pages 319-341
Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View....Pages 343-372
Chromatin Structure and Organization: The Relation with Gene Expression During Development and Disease....Pages 373-396
Front Matter....Pages 397-397
Cancer: An Epigenetic Landscape....Pages 399-417
Epigenetic Regulation of Cancer Stem Cell Gene Expression....Pages 419-434
Role of Epigenetic Mechanisms in the Vascular Complications of Diabetes....Pages 435-454
Epigenetic Changes in Inflammatory and Autoimmune Diseases....Pages 455-478
Front Matter....Pages 397-397
Epigenetic Regulation of HIV-1 Persistence and Evolving Strategies for Virus Eradication....Pages 479-505
Epigenetics in Parkinson’s and Alzheimer’s Diseases....Pages 507-525
Cellular Redox, Epigenetics and Diseases....Pages 527-542
Front Matter....Pages 543-543
Stem Cell Plasticity in Development and Cancer: Epigenetic Origin of Cancer Stem Cells....Pages 545-565
Histone Acetylation as a Therapeutic Target....Pages 567-596
DNA Methylation and Cancer....Pages 597-625
Role of Epigenetics in Inflammation-Associated Diseases....Pages 627-657
Back Matter....Pages 659-682
....Pages 683-689