Ebook: IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity
- Tags: Immunology, Cytokines and Growth Factors, Receptors, Cell Biology, Infectious Diseases, Cancer Research
- Series: Progress in Inflammation Research
- Year: 2013
- Publisher: Springer Basel
- Edition: 2
- Language: English
- pdf
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
Content:
Front Matter....Pages i-ix
Front Matter....Pages 1-1
IL-17A Family, Receptors, Proinflammatory Effects, and Production....Pages 3-10
IL-22 and IL-17: An Overview....Pages 11-35
IL-17 Receptor Family: Structure, Signal Transduction, and Function....Pages 37-54
Contributions of IL-22 to TH17 Responses: Repairing and Protecting Peripheral Tissues....Pages 55-69
Central Role of Th17 Cells in Adaptive Immune Responses....Pages 71-89
Regulatory T cells Versus Th17: Differentiation of Th17 Versus Treg, Are They Mutually Exclusive?....Pages 91-107
Other Sources of IL-17: iNKT Cells....Pages 109-120
Retinoic Acid in Mucosal Immune Regulation....Pages 121-128
Front Matter....Pages 129-129
Critical Role of IL-17 in Experimental Arthritis....Pages 131-141
Dual Role of Th17 Cytokines, IL-17A,F, and IL-22 in Allergic Asthma....Pages 143-155
Inflammasome: IL-1/IL-17 Response in Lung Inflammation....Pages 157-164
The Role of IL-17 in Experimental Autoimmune Myocarditis....Pages 165-175
Th17 Cells in Transplantation: Actors or Innocent Bystanders?....Pages 177-185
Front Matter....Pages 187-187
Is IL-17 Required to Control Tuberculosis?....Pages 189-205
IL-17 and Mucosal Host Defense....Pages 207-218
Role of IL-17 and IL-17 Family Cytokines on Tumor Development....Pages 219-230
Front Matter....Pages 231-231
IL-17 and Th17 Cells in Rheumatoid Arthritis and Other Inflammatory Conditions....Pages 233-242
Targeting Th17 Cells for Therapy of Multiple Sclerosis....Pages 243-257
Involvement of Interleukin-17 Cytokines in Human Asthma....Pages 259-272
IL17 and/or IL22 as Potential Target(s) for Crohn’s Disease....Pages 273-285
Front Matter....Pages 231-231
Role of IL-23, IL-17, and IL-22 in Psoriasis....Pages 287-304
Contribution of IL-22 to Experimental Skin Inflammation....Pages 305-317
Front Matter....Pages 319-319
Genetic Mouse Models to Investigate IL-17 Responses....Pages 321-331
IL-17A as a Therapeutic Target for Autoimmune Diseases....Pages 333-347
Back Matter....Pages 349-354
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naive T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
Content:
Front Matter....Pages i-ix
Front Matter....Pages 1-1
IL-17A Family, Receptors, Proinflammatory Effects, and Production....Pages 3-10
IL-22 and IL-17: An Overview....Pages 11-35
IL-17 Receptor Family: Structure, Signal Transduction, and Function....Pages 37-54
Contributions of IL-22 to TH17 Responses: Repairing and Protecting Peripheral Tissues....Pages 55-69
Central Role of Th17 Cells in Adaptive Immune Responses....Pages 71-89
Regulatory T cells Versus Th17: Differentiation of Th17 Versus Treg, Are They Mutually Exclusive?....Pages 91-107
Other Sources of IL-17: iNKT Cells....Pages 109-120
Retinoic Acid in Mucosal Immune Regulation....Pages 121-128
Front Matter....Pages 129-129
Critical Role of IL-17 in Experimental Arthritis....Pages 131-141
Dual Role of Th17 Cytokines, IL-17A,F, and IL-22 in Allergic Asthma....Pages 143-155
Inflammasome: IL-1/IL-17 Response in Lung Inflammation....Pages 157-164
The Role of IL-17 in Experimental Autoimmune Myocarditis....Pages 165-175
Th17 Cells in Transplantation: Actors or Innocent Bystanders?....Pages 177-185
Front Matter....Pages 187-187
Is IL-17 Required to Control Tuberculosis?....Pages 189-205
IL-17 and Mucosal Host Defense....Pages 207-218
Role of IL-17 and IL-17 Family Cytokines on Tumor Development....Pages 219-230
Front Matter....Pages 231-231
IL-17 and Th17 Cells in Rheumatoid Arthritis and Other Inflammatory Conditions....Pages 233-242
Targeting Th17 Cells for Therapy of Multiple Sclerosis....Pages 243-257
Involvement of Interleukin-17 Cytokines in Human Asthma....Pages 259-272
IL17 and/or IL22 as Potential Target(s) for Crohn’s Disease....Pages 273-285
Front Matter....Pages 231-231
Role of IL-23, IL-17, and IL-22 in Psoriasis....Pages 287-304
Contribution of IL-22 to Experimental Skin Inflammation....Pages 305-317
Front Matter....Pages 319-319
Genetic Mouse Models to Investigate IL-17 Responses....Pages 321-331
IL-17A as a Therapeutic Target for Autoimmune Diseases....Pages 333-347
Back Matter....Pages 349-354
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