Ebook: CRISPR-Cas Systems: RNA-mediated Adaptive Immunity in Bacteria and Archaea

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered.

In this book, experts summarize the state of the art in this exciting field.

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CRISPR-Cas is a recently discovered defense system which protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR-Cas immune systems has been identified in at least half of the available prokaryotic genomes. On-going biochemical and functional analyses have resulted in substantial insight into the functions and possible applications of these fascinating systems, although many secrets remain to be uncovered.

In this book, experts summarize the state of the art of this exciting field.

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CRISPR-Cas is a recently discovered defense system which protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR-Cas immune systems has been identified in at least half of the available prokaryotic genomes. On-going biochemical and functional analyses have resulted in substantial insight into the functions and possible applications of these fascinating systems, although many secrets remain to be uncovered.

In this book, experts summarize the state of the art of this exciting field.

Content:
Front Matter....Pages i-x
Discovery and Seminal Developments in the CRISPR Field....Pages 1-31
Occurrence, Diversity of CRISPR-Cas Systems and Genotyping Implications....Pages 33-59
Evolution and Classification of CRISPR-Cas Systems and Cas Protein Families....Pages 61-91
Regulation of CRISPR-Based Immune Responses....Pages 93-113
crRNA Biogenesis....Pages 115-144
Distribution and Mechanism of the Type I CRISPR-Cas Systems....Pages 145-169
Type II: Streptococcus thermophilus ....Pages 171-200
Type III CRISPR-Cas Systems and the Roles of CRISPR-Cas in Bacterial Virulence....Pages 201-219
CRISPR-Cas Systems to Probe Ecological Diversity and Host–Viral Interactions....Pages 221-250
Roles of CRISPR in Regulation of Physiological Processes....Pages 251-266
Applications of the Versatile CRISPR-Cas Systems....Pages 267-286
CRISPRs in the Microbial Community Context....Pages 287-291
Back Matter....Pages 293-299

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CRISPR-Cas is a recently discovered defense system which protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR-Cas immune systems has been identified in at least half of the available prokaryotic genomes. On-going biochemical and functional analyses have resulted in substantial insight into the functions and possible applications of these fascinating systems, although many secrets remain to be uncovered.

In this book, experts summarize the state of the art of this exciting field.

Content:
Front Matter....Pages i-x
Discovery and Seminal Developments in the CRISPR Field....Pages 1-31
Occurrence, Diversity of CRISPR-Cas Systems and Genotyping Implications....Pages 33-59
Evolution and Classification of CRISPR-Cas Systems and Cas Protein Families....Pages 61-91
Regulation of CRISPR-Based Immune Responses....Pages 93-113
crRNA Biogenesis....Pages 115-144
Distribution and Mechanism of the Type I CRISPR-Cas Systems....Pages 145-169
Type II: Streptococcus thermophilus ....Pages 171-200
Type III CRISPR-Cas Systems and the Roles of CRISPR-Cas in Bacterial Virulence....Pages 201-219
CRISPR-Cas Systems to Probe Ecological Diversity and Host–Viral Interactions....Pages 221-250
Roles of CRISPR in Regulation of Physiological Processes....Pages 251-266
Applications of the Versatile CRISPR-Cas Systems....Pages 267-286
CRISPRs in the Microbial Community Context....Pages 287-291
Back Matter....Pages 293-299
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