Ebook: Peroxisomes and their Key Role in Cellular Signaling and Metabolism
- Tags: Biomedicine general, Cell Biology, Cell Physiology, Animal Biochemistry, Plant Biochemistry, Proteomics
- Series: Subcellular Biochemistry 69
- Year: 2013
- Publisher: Springer Netherlands
- Edition: 1
- Language: English
- pdf
Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. In recent years it has become increasingly clear that peroxisomes are involved in a range of important cellular functions in almost all eukaryotic cells. In higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid alpha-oxidation, glyoxylate detoxification, etc, and in humans peroxisomes are associated with several important genetic diseases. In plants, peroxisomes carry out the fatty acid beta-oxidation, photorespiration, metabolism of ROS, RNS and RSS, photomorphogenesis, biosynthesis of phytohormones, senescence, and defence against pathogens and herbivores. In recent years it has been postulated a possible contribution of peroxisomes to cellular signaling. In this volume an updated view of the capacity and function of peroxisomes from human, animal, fungal and plant origin as cell generators of different signal molecules involved in distinct processes of high physiological importance is presented.
Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. Today it is known that fatty acid ?-oxidation is a general feature of virtually all types of peroxisomes, but in higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid ?-oxidation, and glyoxylate detoxification, and in humans peroxisomes are associated with several important genetic diseases. Among the different new roles for human peroxisomes discovered in recent years are antiviral innate immunity, peptide hormone metabolism, brain aging and Alzheimer’s disease, and age-related diseases. In fungi, new findings have broadened the number of secondary metabolites that are synthesized in peroxisomes, such as antibiotics and several toxins, and have evidenced their involvement in biotin biosynthesis, fungal development and plant pathogenesis. In plants, peroxisomes carry out different functions, apart from fatty acid ?-oxidation, mainly including photorespiration, metabolism of reactive oxygen, nitrogen and sulfur species, photomorphogenesis, biosynthesis of phytohormones, senescence, and defense against pathogens and hervibores.
Two important characteristics of peroxisomes are their metabolic plasticity and capacity of sharing metabolic pathways with other cell compartments. In recent years, a function for peroxisomes as key centers of the cellular-signaling apparatus which could influence the regulatory network of the cell has been postulated. The diverse key physiological functions that have been demonstrated for peroxisomes from different origins strongly indicate the interest of studying the role of peroxisomes as a cellular source of different signaling molecules. This book presents recent advances in the function and metabolism of peroxisomes from human, animal, fungal and plant origin and their metabolic interconnection with other cell compartments, showing the central role played by peroxisomes as cell generators of different signaling molecules involved in distinct processes of high physiological importance.
Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. Today it is known that fatty acid ?-oxidation is a general feature of virtually all types of peroxisomes, but in higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid ?-oxidation, and glyoxylate detoxification, and in humans peroxisomes are associated with several important genetic diseases. Among the different new roles for human peroxisomes discovered in recent years are antiviral innate immunity, peptide hormone metabolism, brain aging and Alzheimer’s disease, and age-related diseases. In fungi, new findings have broadened the number of secondary metabolites that are synthesized in peroxisomes, such as antibiotics and several toxins, and have evidenced their involvement in biotin biosynthesis, fungal development and plant pathogenesis. In plants, peroxisomes carry out different functions, apart from fatty acid ?-oxidation, mainly including photorespiration, metabolism of reactive oxygen, nitrogen and sulfur species, photomorphogenesis, biosynthesis of phytohormones, senescence, and defense against pathogens and hervibores.
Two important characteristics of peroxisomes are their metabolic plasticity and capacity of sharing metabolic pathways with other cell compartments. In recent years, a function for peroxisomes as key centers of the cellular-signaling apparatus which could influence the regulatory network of the cell has been postulated. The diverse key physiological functions that have been demonstrated for peroxisomes from different origins strongly indicate the interest of studying the role of peroxisomes as a cellular source of different signaling molecules. This book presents recent advances in the function and metabolism of peroxisomes from human, animal, fungal and plant origin and their metabolic interconnection with other cell compartments, showing the central role played by peroxisomes as cell generators of different signaling molecules involved in distinct processes of high physiological importance.
Content:
Front Matter....Pages i-xii
Peroxisome Interactions and Cross-Talk with Other Subcellular Compartments in Animal Cells....Pages 1-22
Peroxisomes in Human Health and Disease: Metabolic Pathways, Metabolite Transport, Interplay with Other Organelles and Signal Transduction....Pages 23-44
Aging, Age-Related Diseases and Peroxisomes....Pages 45-65
Peroxisomes and the Antiviral Responses of Mammalian Cells....Pages 67-75
Peroxisome Proliferator-Activated Receptor-? Signaling in Hepatocarcinogenesis....Pages 77-99
Involvement of Human Peroxisomes in Biosynthesis and Signaling of Steroid and Peptide Hormones....Pages 101-110
Peroxisome Ca2+ Homeostasis in Animal and Plant Cells....Pages 111-133
The Versatility of Peroxisome Function in Filamentous Fungi....Pages 135-152
Essential Roles of Peroxisomally Produced and Metabolized Biomolecules in Regulating Yeast Longevity....Pages 153-167
Metabolite Transporters of the Plant Peroxisomal Membrane: Known and Unknown....Pages 169-194
Peroxisomes and Photomorphogenesis....Pages 195-211
Biosynthesis of Vitamin K1 (Phylloquinone) by Plant Peroxisomes and Its Integration into Signaling Molecule Synthesis Pathways....Pages 213-229
Role of Peroxisomes as a Source of Reactive Oxygen Species (ROS) Signaling Molecules....Pages 231-255
Peroxisomes as a Source of Auxin Signaling Molecules....Pages 257-281
Peroxisomes as Cell Generators of Reactive Nitrogen Species (RNS) Signal Molecules....Pages 283-298
Role of Plant Peroxisomes in the Production of Jasmonic Acid-Based Signals....Pages 299-313
Role of Plant Peroxisomes in Protection Against Herbivores....Pages 315-328
Function of Peroxisomes in Plant-Pathogen Interactions....Pages 329-345
Back Matter....Pages 347-350
Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. Today it is known that fatty acid ?-oxidation is a general feature of virtually all types of peroxisomes, but in higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid ?-oxidation, and glyoxylate detoxification, and in humans peroxisomes are associated with several important genetic diseases. Among the different new roles for human peroxisomes discovered in recent years are antiviral innate immunity, peptide hormone metabolism, brain aging and Alzheimer’s disease, and age-related diseases. In fungi, new findings have broadened the number of secondary metabolites that are synthesized in peroxisomes, such as antibiotics and several toxins, and have evidenced their involvement in biotin biosynthesis, fungal development and plant pathogenesis. In plants, peroxisomes carry out different functions, apart from fatty acid ?-oxidation, mainly including photorespiration, metabolism of reactive oxygen, nitrogen and sulfur species, photomorphogenesis, biosynthesis of phytohormones, senescence, and defense against pathogens and hervibores.
Two important characteristics of peroxisomes are their metabolic plasticity and capacity of sharing metabolic pathways with other cell compartments. In recent years, a function for peroxisomes as key centers of the cellular-signaling apparatus which could influence the regulatory network of the cell has been postulated. The diverse key physiological functions that have been demonstrated for peroxisomes from different origins strongly indicate the interest of studying the role of peroxisomes as a cellular source of different signaling molecules. This book presents recent advances in the function and metabolism of peroxisomes from human, animal, fungal and plant origin and their metabolic interconnection with other cell compartments, showing the central role played by peroxisomes as cell generators of different signaling molecules involved in distinct processes of high physiological importance.
Content:
Front Matter....Pages i-xii
Peroxisome Interactions and Cross-Talk with Other Subcellular Compartments in Animal Cells....Pages 1-22
Peroxisomes in Human Health and Disease: Metabolic Pathways, Metabolite Transport, Interplay with Other Organelles and Signal Transduction....Pages 23-44
Aging, Age-Related Diseases and Peroxisomes....Pages 45-65
Peroxisomes and the Antiviral Responses of Mammalian Cells....Pages 67-75
Peroxisome Proliferator-Activated Receptor-? Signaling in Hepatocarcinogenesis....Pages 77-99
Involvement of Human Peroxisomes in Biosynthesis and Signaling of Steroid and Peptide Hormones....Pages 101-110
Peroxisome Ca2+ Homeostasis in Animal and Plant Cells....Pages 111-133
The Versatility of Peroxisome Function in Filamentous Fungi....Pages 135-152
Essential Roles of Peroxisomally Produced and Metabolized Biomolecules in Regulating Yeast Longevity....Pages 153-167
Metabolite Transporters of the Plant Peroxisomal Membrane: Known and Unknown....Pages 169-194
Peroxisomes and Photomorphogenesis....Pages 195-211
Biosynthesis of Vitamin K1 (Phylloquinone) by Plant Peroxisomes and Its Integration into Signaling Molecule Synthesis Pathways....Pages 213-229
Role of Peroxisomes as a Source of Reactive Oxygen Species (ROS) Signaling Molecules....Pages 231-255
Peroxisomes as a Source of Auxin Signaling Molecules....Pages 257-281
Peroxisomes as Cell Generators of Reactive Nitrogen Species (RNS) Signal Molecules....Pages 283-298
Role of Plant Peroxisomes in the Production of Jasmonic Acid-Based Signals....Pages 299-313
Role of Plant Peroxisomes in Protection Against Herbivores....Pages 315-328
Function of Peroxisomes in Plant-Pathogen Interactions....Pages 329-345
Back Matter....Pages 347-350
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