Ebook: Systems Biology of Tuberculosis

The book starts with a general introduction into the relevance of systems biology for understanding tuberculosis. This will be followed by several chapters which describe the application of systems biology to various aspects of the study of the pathogen, Mycobacterium tuberculosis, and its interaction with the host. The book provides the reader with an account of how the new science of systems biology is providing novel insights into the ancient scourge of tuberculosis. It will also describe how systems biology can be applied to the control of tuberculosis, including the development of new treatments, vaccines and diagnostics.

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Tuberculosis remains one of the world’s biggest killers responsible for more than a million deaths each year. New drugs and new vaccines are urgently needed to tackle the disease. This book describes the application of this century’s first new science, systems biology, to the study of tuberculosis. After introducing the basic principles of systems biology, successive chapters describe how systems-based approaches provide new insights into gene regulation, metabolism, protein-protein interaction, host-pathogen interactions, the immune response, persistence, drug treatment and diagnosis of tuberculosis. This book will be an invaluable aid to anyone interested in exploring how the latest science is helping us to understand this ancient disease.

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Tuberculosis remains one of the world’s biggest killers responsible for more than a million deaths each year. New drugs and new vaccines are urgently needed to tackle the disease. This book describes the application of this century’s first new science, systems biology, to the study of tuberculosis. After introducing the basic principles of systems biology, successive chapters describe how systems-based approaches provide new insights into gene regulation, metabolism, protein-protein interaction, host-pathogen interactions, the immune response, persistence, drug treatment and diagnosis of tuberculosis. This book will be an invaluable aid to anyone interested in exploring how the latest science is helping us to understand this ancient disease.
Content:
Front Matter....Pages i-xv
Modeling Mycobacterium tuberculosis H37Rv In Silico....Pages 1-19
Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis ....Pages 21-35
Probing Gene Regulatory Networks to Decipher Host–Pathogen Interactions....Pages 37-54
Metabolism of Mycobacterium tuberculosis ....Pages 55-78
Protein–Protein Interaction in the -Omics Era: Understanding Mycobacterium tuberculosis Function....Pages 79-106
Host–Pathogen Interactions....Pages 107-126
A Systems Biology Approach for Understanding Granuloma Formation and Function in Tuberculosis....Pages 127-155
Stochastic Gene Expression in Bacterial Pathogens: A Mechanism for Persistence?....Pages 157-177
Drug Discovery....Pages 179-192
Immunological Biomarkers for Tuberculosis: Potential for a Combinatorial Approach....Pages 193-219
Back Matter....Pages 221-226

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Tuberculosis remains one of the world’s biggest killers responsible for more than a million deaths each year. New drugs and new vaccines are urgently needed to tackle the disease. This book describes the application of this century’s first new science, systems biology, to the study of tuberculosis. After introducing the basic principles of systems biology, successive chapters describe how systems-based approaches provide new insights into gene regulation, metabolism, protein-protein interaction, host-pathogen interactions, the immune response, persistence, drug treatment and diagnosis of tuberculosis. This book will be an invaluable aid to anyone interested in exploring how the latest science is helping us to understand this ancient disease.
Content:
Front Matter....Pages i-xv
Modeling Mycobacterium tuberculosis H37Rv In Silico....Pages 1-19
Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis ....Pages 21-35
Probing Gene Regulatory Networks to Decipher Host–Pathogen Interactions....Pages 37-54
Metabolism of Mycobacterium tuberculosis ....Pages 55-78
Protein–Protein Interaction in the -Omics Era: Understanding Mycobacterium tuberculosis Function....Pages 79-106
Host–Pathogen Interactions....Pages 107-126
A Systems Biology Approach for Understanding Granuloma Formation and Function in Tuberculosis....Pages 127-155
Stochastic Gene Expression in Bacterial Pathogens: A Mechanism for Persistence?....Pages 157-177
Drug Discovery....Pages 179-192
Immunological Biomarkers for Tuberculosis: Potential for a Combinatorial Approach....Pages 193-219
Back Matter....Pages 221-226
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