Ebook: Corynebacterium glutamicum: Biology and Biotechnology

Corynebacterium glutamicum was discovered in Japan in 1956 as a natural glutamate producer. Its “microbial factory” qualities, such as its physiological plasticity and robust catalytic functionalities, have since facilitated the development of efficient production processes for amino acids, nucleotides and vitamins.

This monograph illustrates how the information gleaned from complete genome sequencing allows the rational engineering of the entire cellular metabolism and how systems biology permits the further optimization of C. glutamicum as a biocatalyst. Aspects of gene regulation, metabolic pathways, sugar uptake, protein secretion, cell division and biorefinery applications highlight the enormous biotechnological and biorefinery potential.

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Corynebacterium glutamicum was discovered in Japan in 1956 as a natural glutamate producer. Its “microbial factory” qualities, such as its physiological plasticity and robust catalytic functionalities, have since facilitated the development of efficient production processes for amino acids, nucleotides and vitamins. This monograph illustrates how the information gleaned from complete genome sequencing allows the rational engineering of the entire cellular metabolism and how systems biology permits the further optimization of C. glutamicum as a biocatalyst. Aspects of gene regulation, metabolic pathways, sugar uptake, protein secretion, cell division and biorefinery applications highlight the enormous biotechnological and biorefinery potential.

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Corynebacterium glutamicum was discovered in Japan in 1956 as a natural glutamate producer. Its “microbial factory” qualities, such as its physiological plasticity and robust catalytic functionalities, have since facilitated the development of efficient production processes for amino acids, nucleotides and vitamins. This monograph illustrates how the information gleaned from complete genome sequencing allows the rational engineering of the entire cellular metabolism and how systems biology permits the further optimization of C. glutamicum as a biocatalyst. Aspects of gene regulation, metabolic pathways, sugar uptake, protein secretion, cell division and biorefinery applications highlight the enormous biotechnological and biorefinery potential.
Content:
Front Matter....Pages i-viii
The Biotechnological Potential of Corynebacterium glutamicum, from Umami to Chemurgy ....Pages 1-49
Promoters and Plasmid Vectors of Corynebacterium glutamicum ....Pages 51-88
Genome Engineering of Corynebacterium glutamicum ....Pages 89-105
Amino Acid Production by Corynebacterium glutamicum ....Pages 107-147
Biorefinery Applications of Corynebacterium glutamicum ....Pages 149-172
Transcriptome/Proteome Analysis of Corynebacterium glutamicum ....Pages 173-216
Pathways at Work: Metabolic Flux Analysis of the Industrial Cell Factory Corynebacterium glutamicum ....Pages 217-237
The Transcriptional Regulatory Network of Corynebacterium glutamicum ....Pages 239-261
Regulation of Sugar Uptake, Glycolysis, and the Pentose Phosphate Pathway in Corynebacterium glutamicum ....Pages 263-279
TCA Cycle and Glyoxylate Shunt of Corynebacterium glutamicum ....Pages 281-313
Respiratory Chain and Energy Metabolism of Corynebacterium glutamicum ....Pages 315-334
Amino Acid Exporters in Corynebacterium glutamicum ....Pages 335-349
Protein Secretion Systems of Corynebacterium glutamicum ....Pages 351-389
Cell Division Mechanism of Corynebacterium glutamicum ....Pages 391-407
Back Matter....Pages 409-416

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Corynebacterium glutamicum was discovered in Japan in 1956 as a natural glutamate producer. Its “microbial factory” qualities, such as its physiological plasticity and robust catalytic functionalities, have since facilitated the development of efficient production processes for amino acids, nucleotides and vitamins. This monograph illustrates how the information gleaned from complete genome sequencing allows the rational engineering of the entire cellular metabolism and how systems biology permits the further optimization of C. glutamicum as a biocatalyst. Aspects of gene regulation, metabolic pathways, sugar uptake, protein secretion, cell division and biorefinery applications highlight the enormous biotechnological and biorefinery potential.
Content:
Front Matter....Pages i-viii
The Biotechnological Potential of Corynebacterium glutamicum, from Umami to Chemurgy ....Pages 1-49
Promoters and Plasmid Vectors of Corynebacterium glutamicum ....Pages 51-88
Genome Engineering of Corynebacterium glutamicum ....Pages 89-105
Amino Acid Production by Corynebacterium glutamicum ....Pages 107-147
Biorefinery Applications of Corynebacterium glutamicum ....Pages 149-172
Transcriptome/Proteome Analysis of Corynebacterium glutamicum ....Pages 173-216
Pathways at Work: Metabolic Flux Analysis of the Industrial Cell Factory Corynebacterium glutamicum ....Pages 217-237
The Transcriptional Regulatory Network of Corynebacterium glutamicum ....Pages 239-261
Regulation of Sugar Uptake, Glycolysis, and the Pentose Phosphate Pathway in Corynebacterium glutamicum ....Pages 263-279
TCA Cycle and Glyoxylate Shunt of Corynebacterium glutamicum ....Pages 281-313
Respiratory Chain and Energy Metabolism of Corynebacterium glutamicum ....Pages 315-334
Amino Acid Exporters in Corynebacterium glutamicum ....Pages 335-349
Protein Secretion Systems of Corynebacterium glutamicum ....Pages 351-389
Cell Division Mechanism of Corynebacterium glutamicum ....Pages 391-407
Back Matter....Pages 409-416
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