Ebook: Proteins of the Nucleolus: Regulation, Translocation, & Biomedical Functions

This book contains 14 original review chapters each yielding new, exciting and intriguing data about the emerging understanding of nucleolar structure and function in normal, stressed and diseased cells. The goal of this work is to provide special insight into the nucleolus of the past, present and future, as well its regulation, translocation, and biomedical function. A multitude of topics are introduced and discussed in detail, including nucleologenesis, nucleolar architecture, nucleolar targeting, retention, anchoring, translocation, and the relationship between the nucleolus and cancer. This book also brings together work from several different species, from human to Drosophila to Dictyostelium and other eukaryotic microbes. The final chapter summarizes some of the issues brought up in the various chapters with a view to future research. This book supports the continued emergence of the nucleolus as a dynamic intranuclear region that oversees a vast diversity of events.

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This book contains 14 original review chapters each yielding new, exciting and intriguing data about the emerging understanding of nucleolar structure and function in normal, stressed and diseased cells. The goal of this work is to provide special insight into the nucleolus of the past, present and future, as well its regulation, translocation, and biomedical function. A multitude of topics are introduced and discussed in detail, including nucleologenesis, nucleolar architecture, nucleolar targeting, retention, anchoring, translocation, and the relationship between the nucleolus and cancer. This book also brings together work from several different species, from human to Drosophila to Dictyostelium and other eukaryotic microbes. The final chapter summarizes some of the issues brought up in the various chapters with a view to future research. This book supports the continued emergence of the nucleolus as a dynamic intranuclear region that oversees a vast diversity of events.

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This book contains 14 original review chapters each yielding new, exciting and intriguing data about the emerging understanding of nucleolar structure and function in normal, stressed and diseased cells. The goal of this work is to provide special insight into the nucleolus of the past, present and future, as well its regulation, translocation, and biomedical function. A multitude of topics are introduced and discussed in detail, including nucleologenesis, nucleolar architecture, nucleolar targeting, retention, anchoring, translocation, and the relationship between the nucleolus and cancer. This book also brings together work from several different species, from human to Drosophila to Dictyostelium and other eukaryotic microbes. The final chapter summarizes some of the issues brought up in the various chapters with a view to future research. This book supports the continued emergence of the nucleolus as a dynamic intranuclear region that oversees a vast diversity of events.
Content:
Front Matter....Pages i-vi
Front Matter....Pages 1-1
Proteins of the Nucleolus: An Introduction....Pages 3-15
Front Matter....Pages 17-17
Functional Consequences of Nuclear and Nucleolar Architecture....Pages 19-38
rDNA and Nucleologenesis in Drosophila ....Pages 39-78
The Nucleolus of Dictyostelium and Other Lower Eukaryotes....Pages 79-94
Human rDNA Genes: Identification of Four Fractions, Their Functions and Nucleolar Location....Pages 95-118
Chromatin Organization and the Mammalian Nucleolus....Pages 119-148
Chaperones and Multitasking Proteins in the Nucleolus....Pages 149-172
Front Matter....Pages 173-173
Nucleolar Localization/Retention Signals....Pages 175-196
Nucleolar Transport of Putative GTPase GNL1 and Related Proteins....Pages 197-207
Nucleolar Protein Anchoring and Translocation....Pages 209-247
Front Matter....Pages 249-249
The Nucleolus as a Stress Response Organelle....Pages 251-273
The Nucleolar Aspect of Breast Cancer....Pages 275-304
Cysteine Proteinase Inhibitors in the Nucleus and Nucleolus in Activated Macrophages....Pages 305-321
Nucleolar Proteins and Cancer: The Roles of Aurora A-Interacting Nucleolar Proteins in Mitosis and Cancer....Pages 323-342
Nucleolar Transplantation and Human Embryogenesis....Pages 343-357
Front Matter....Pages 359-359
The Nucleolus: From Its Formation to the Future....Pages 361-365
Back Matter....Pages 367-371

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This book contains 14 original review chapters each yielding new, exciting and intriguing data about the emerging understanding of nucleolar structure and function in normal, stressed and diseased cells. The goal of this work is to provide special insight into the nucleolus of the past, present and future, as well its regulation, translocation, and biomedical function. A multitude of topics are introduced and discussed in detail, including nucleologenesis, nucleolar architecture, nucleolar targeting, retention, anchoring, translocation, and the relationship between the nucleolus and cancer. This book also brings together work from several different species, from human to Drosophila to Dictyostelium and other eukaryotic microbes. The final chapter summarizes some of the issues brought up in the various chapters with a view to future research. This book supports the continued emergence of the nucleolus as a dynamic intranuclear region that oversees a vast diversity of events.
Content:
Front Matter....Pages i-vi
Front Matter....Pages 1-1
Proteins of the Nucleolus: An Introduction....Pages 3-15
Front Matter....Pages 17-17
Functional Consequences of Nuclear and Nucleolar Architecture....Pages 19-38
rDNA and Nucleologenesis in Drosophila ....Pages 39-78
The Nucleolus of Dictyostelium and Other Lower Eukaryotes....Pages 79-94
Human rDNA Genes: Identification of Four Fractions, Their Functions and Nucleolar Location....Pages 95-118
Chromatin Organization and the Mammalian Nucleolus....Pages 119-148
Chaperones and Multitasking Proteins in the Nucleolus....Pages 149-172
Front Matter....Pages 173-173
Nucleolar Localization/Retention Signals....Pages 175-196
Nucleolar Transport of Putative GTPase GNL1 and Related Proteins....Pages 197-207
Nucleolar Protein Anchoring and Translocation....Pages 209-247
Front Matter....Pages 249-249
The Nucleolus as a Stress Response Organelle....Pages 251-273
The Nucleolar Aspect of Breast Cancer....Pages 275-304
Cysteine Proteinase Inhibitors in the Nucleus and Nucleolus in Activated Macrophages....Pages 305-321
Nucleolar Proteins and Cancer: The Roles of Aurora A-Interacting Nucleolar Proteins in Mitosis and Cancer....Pages 323-342
Nucleolar Transplantation and Human Embryogenesis....Pages 343-357
Front Matter....Pages 359-359
The Nucleolus: From Its Formation to the Future....Pages 361-365
Back Matter....Pages 367-371
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