Ebook: Iron Acquisition by the Genus Mycobacterium: History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development
- Tags: Microbiology, Protein-Ligand Interactions, Inorganic Chemistry, Bioorganic Chemistry, Infectious Diseases
- Series: SpringerBriefs in Molecular Science
- Year: 2013
- Publisher: Springer International Publishing
- Edition: 1
- Language: English
- pdf
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
Content:
Front Matter....Pages i-v
Introduction to the Book....Pages 1-2
A History of Iron Metabolism in the Mycobacteria....Pages 3-39
Mycobacterial Iron Acquisition Mechanisms....Pages 41-52
Siderocalin Combats Mycobacterial Infections....Pages 53-64
Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis ....Pages 65-88
Back Matter....Pages 89-92
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
Content:
Front Matter....Pages i-v
Introduction to the Book....Pages 1-2
A History of Iron Metabolism in the Mycobacteria....Pages 3-39
Mycobacterial Iron Acquisition Mechanisms....Pages 41-52
Siderocalin Combats Mycobacterial Infections....Pages 53-64
Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis ....Pages 65-88
Back Matter....Pages 89-92
....