Ebook: Behavioral Neurogenetics

This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.

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The field of behavioral neurogenetics has developed significantly over the past two decades. This has been largely driven by technical advances in the field of molecular genetics both in model systems and in clinical analysis. Indeed, it is hoped that the elucidation and ongoing functionalisation of the human genome may provide new insights into the aetiology, course and, ultimately, treatment of psychiatric illnesses. This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.

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The field of behavioral neurogenetics has developed significantly over the past two decades. This has been largely driven by technical advances in the field of molecular genetics both in model systems and in clinical analysis. Indeed, it is hoped that the elucidation and ongoing functionalisation of the human genome may provide new insights into the aetiology, course and, ultimately, treatment of psychiatric illnesses. This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.

Content:
Front Matter....Pages i-xi
Using Zebrafish to Unravel the Genetics of Complex Brain Disorders....Pages 3-24
Forward Genetic Approaches to Understanding Complex Behaviors....Pages 25-58
Mouse Models of the 5-HTTLPR ? Stress Risk Factor for Depression....Pages 59-72
Behavioral and Pharmacogenetics of Aggressive Behavior....Pages 73-138
Selectively Bred Rodents as Models of Depression and Anxiety....Pages 139-187
Stress-Induced Deficits in Cognition and Emotionality: A Role for Glutamate....Pages 189-207
Susceptibility Genes for Schizophrenia: Mutant Models, Endophenotypes and Psychobiology....Pages 209-250
Genetic Models of Sensorimotor Gating: Relevance to Neuropsychiatric Disorders....Pages 251-318
Applications of Second Generation Sequencing Technologies in Complex Disorders....Pages 321-343
Rare Genomic Deletions and Duplications and their Role in Neurodevelopmental Disorders....Pages 345-360
Toward a Mechanistic Understanding of How Variability in Neurobiology Shapes Individual Differences in Behavior....Pages 361-393
Behavioural Genetics of Childhood Disorders....Pages 395-428
Schizophrenia Genes: On the Matter of Their Convergence....Pages 429-440
Gene ? Environment Interaction Models in Psychiatric Genetics....Pages 441-462
Behavioral Genetics of Affective and Anxiety Disorders....Pages 463-502
Behavioural Genetics of the Serotonin Transporter....Pages 503-535
Genetic Factors Modulating the Response to Stimulant Drugs in Humans....Pages 537-577
The Cognitive Genetics of Neuropsychiatric Disorders....Pages 579-613
Behavioral Genetics of Neurodegenerative Disorders....Pages 615-631
Back Matter....Pages 633-636

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The field of behavioral neurogenetics has developed significantly over the past two decades. This has been largely driven by technical advances in the field of molecular genetics both in model systems and in clinical analysis. Indeed, it is hoped that the elucidation and ongoing functionalisation of the human genome may provide new insights into the aetiology, course and, ultimately, treatment of psychiatric illnesses. This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.

Content:
Front Matter....Pages i-xi
Using Zebrafish to Unravel the Genetics of Complex Brain Disorders....Pages 3-24
Forward Genetic Approaches to Understanding Complex Behaviors....Pages 25-58
Mouse Models of the 5-HTTLPR ? Stress Risk Factor for Depression....Pages 59-72
Behavioral and Pharmacogenetics of Aggressive Behavior....Pages 73-138
Selectively Bred Rodents as Models of Depression and Anxiety....Pages 139-187
Stress-Induced Deficits in Cognition and Emotionality: A Role for Glutamate....Pages 189-207
Susceptibility Genes for Schizophrenia: Mutant Models, Endophenotypes and Psychobiology....Pages 209-250
Genetic Models of Sensorimotor Gating: Relevance to Neuropsychiatric Disorders....Pages 251-318
Applications of Second Generation Sequencing Technologies in Complex Disorders....Pages 321-343
Rare Genomic Deletions and Duplications and their Role in Neurodevelopmental Disorders....Pages 345-360
Toward a Mechanistic Understanding of How Variability in Neurobiology Shapes Individual Differences in Behavior....Pages 361-393
Behavioural Genetics of Childhood Disorders....Pages 395-428
Schizophrenia Genes: On the Matter of Their Convergence....Pages 429-440
Gene ? Environment Interaction Models in Psychiatric Genetics....Pages 441-462
Behavioral Genetics of Affective and Anxiety Disorders....Pages 463-502
Behavioural Genetics of the Serotonin Transporter....Pages 503-535
Genetic Factors Modulating the Response to Stimulant Drugs in Humans....Pages 537-577
The Cognitive Genetics of Neuropsychiatric Disorders....Pages 579-613
Behavioral Genetics of Neurodegenerative Disorders....Pages 615-631
Back Matter....Pages 633-636
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