Ebook: Notch Signaling in Embryology and Cancer

The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research.

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Content:
Front Matter....Pages i-xxi
The Molecular Basis of Notch Signaling: A Brief Overview....Pages 1-14
The Role of Adams in Notch Signaling....Pages 15-36
Metabolism and Transportation Pathways Of GDP-Fucose that are Required for the O-Fucosylation Of Notch....Pages 37-46
Notch Signaling and the Generation of Cell Diversity in Drosophila Neuroblast Lineages....Pages 47-60
NEPRO: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex....Pages 61-70
Notch Signaling and Development of the Hematopoietic System....Pages 71-88
Notch Signaling in Lung Development and Disease....Pages 89-98
The Role of Notch Signaling in Kidney Development and Disease....Pages 99-113
Notch Signaling and the Developing Skeleton....Pages 114-130
Notch Signaling and the Developing Skin Epidermis....Pages 131-141
Notch Signaling and the Developing Hair Follicle....Pages 142-160
Notch Signaling and the Developing Inner Ear....Pages 161-173
Notch Signaling in Cancer Stem Cells....Pages 174-185
Notch Signaling Pathway and Cancer Metastasis....Pages 186-198
Notch, Apoptosis and Cancer....Pages 199-209
Ligand-Dependent Notch Signaling in Vascular Formation....Pages 210-222
Notch and the p53 Clan of Transcription Factors....Pages 223-240
Notch Signaling and Breast Cancer....Pages 241-257
Notch Signaling and Malignant Melanoma....Pages 258-264
Notch-Signaling and Nonmelanoma Skin Cancer: An Ancient Friend, Revisited....Pages 265-271
Notch Signaling and Intestinal Cancer....Pages 272-288
Notch Signaling and Brain Tumors....Pages 289-304
Notch Inhibition as a Promising New Approach to Cancer Therapy....Pages 305-319
Back Matter....Pages 321-328

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Content:
Front Matter....Pages i-xxi
The Molecular Basis of Notch Signaling: A Brief Overview....Pages 1-14
The Role of Adams in Notch Signaling....Pages 15-36
Metabolism and Transportation Pathways Of GDP-Fucose that are Required for the O-Fucosylation Of Notch....Pages 37-46
Notch Signaling and the Generation of Cell Diversity in Drosophila Neuroblast Lineages....Pages 47-60
NEPRO: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex....Pages 61-70
Notch Signaling and Development of the Hematopoietic System....Pages 71-88
Notch Signaling in Lung Development and Disease....Pages 89-98
The Role of Notch Signaling in Kidney Development and Disease....Pages 99-113
Notch Signaling and the Developing Skeleton....Pages 114-130
Notch Signaling and the Developing Skin Epidermis....Pages 131-141
Notch Signaling and the Developing Hair Follicle....Pages 142-160
Notch Signaling and the Developing Inner Ear....Pages 161-173
Notch Signaling in Cancer Stem Cells....Pages 174-185
Notch Signaling Pathway and Cancer Metastasis....Pages 186-198
Notch, Apoptosis and Cancer....Pages 199-209
Ligand-Dependent Notch Signaling in Vascular Formation....Pages 210-222
Notch and the p53 Clan of Transcription Factors....Pages 223-240
Notch Signaling and Breast Cancer....Pages 241-257
Notch Signaling and Malignant Melanoma....Pages 258-264
Notch-Signaling and Nonmelanoma Skin Cancer: An Ancient Friend, Revisited....Pages 265-271
Notch Signaling and Intestinal Cancer....Pages 272-288
Notch Signaling and Brain Tumors....Pages 289-304
Notch Inhibition as a Promising New Approach to Cancer Therapy....Pages 305-319
Back Matter....Pages 321-328
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