Ebook: Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.

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This volume of the Subcellular Biochemistry series is devoted to the aggregation and fibrillogenesis of the amyloid-forming peptides and proteins, including emphasis on oligomer formation as well as fibril formation. The diverse topics included here are presented within 22 chapters, covering many of the relevant topics from both a basic science and clinical perspective. The authorship of these chapters is thoroughly international, with authoritative contributions from active researchers. Fundamental structural and cellular studies using many different technical approaches are presented, leading through to clinical and therapeutic aspects of the amyloid diseases, considered from both pharmaceutical and natural product view points. It is hoped that this book will be of use to both biomedical scientists and clinicians wishing to keep abreast of this rapidly advancing field, of direct importance to the understanding of cerebral neurodegenerative disease and systemic amyloid disease.

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This volume of the Subcellular Biochemistry series is devoted to the aggregation and fibrillogenesis of the amyloid-forming peptides and proteins, including emphasis on oligomer formation as well as fibril formation. The diverse topics included here are presented within 22 chapters, covering many of the relevant topics from both a basic science and clinical perspective. The authorship of these chapters is thoroughly international, with authoritative contributions from active researchers. Fundamental structural and cellular studies using many different technical approaches are presented, leading through to clinical and therapeutic aspects of the amyloid diseases, considered from both pharmaceutical and natural product view points. It is hoped that this book will be of use to both biomedical scientists and clinicians wishing to keep abreast of this rapidly advancing field, of direct importance to the understanding of cerebral neurodegenerative disease and systemic amyloid disease.

Content:
Front Matter....Pages 1-1
Front Matter....Pages 1-1
Introduction and Technical Survey: Protein Aggregation and Fibrillogenesis....Pages 3-25
Front Matter....Pages 27-27
Fibril Formation by Short Synthetic Peptides....Pages 29-51
Tau Fibrillogenesis....Pages 53-74
?-Synuclein Aggregation and Modulating Factors....Pages 75-90
Pathological Self-Aggregation ofb2-Microglobulin: A Challenge for Protein Biophysics....Pages 91-108
Islet Amyloid Polypeptide: Aggregation and Fibrillogenesisin vitroand Its Inhibition....Pages 109-164
Mechanisms of Transthyretin Aggregation and Toxicity....Pages 165-183
Fibrillogenesis of Huntingtin and Other Glutamine Containing Proteins....Pages 185-209
Aggregation and Fibrillogenesis of Proteins not Associated with Disease: A Few Case Studies....Pages 211-224
Experimental Inhibition of Peptide Fibrillogenesis by Synthetic Peptides, Carbohydrates and Drugs....Pages 225-251
Experimental Inhibition of Fibrillogenesis and Neurotoxicity by amyloid-beta (A?) and Other Disease-Related Peptides/Proteins by Plant Extracts and Herbal Compounds....Pages 253-270
Front Matter....Pages 271-294
Alzheimer’s Disease....Pages 295-326
Modeling the Polyglutamine Aggregation Pathway in Huntington’s Disease: From Basic Studies to Clinical Applications....Pages 327-327
Parkinson’s Disease....Pages 329-352
Human Prion Diseases: From Kuru to Variant Creutzfeldt-Jakob Disease....Pages 353-388
Animal Prion Diseases....Pages 389-455
?2-Microglobulin Amyloidosis....Pages 457-496
Systemic AA Amyloidosis....Pages 497-516
Front Matter....Pages 517-540
Familial Amyloidotic Polyneuropathy and Transthyretin....Pages 541-564
The Challenge of Systemic Immunoglobulin Light-Chain Amyloidosis (AL)....Pages 327-327
Back Matter....Pages 565-607
....Pages 609-642