Ebook: RAMPs

Among the many GPCRs discovered, the calcitonin family of receptors comprise of members that regulate a number of physiological processes and are involved in many pathological conditions. Therefore, understanding how these receptors function is a critical question in the field. When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of GPCRs of the calcitonin family, it widely opened the field of receptor life cycle. Hundreds of studies have confirmed the importance of RAMPs in the life cycle of this receptor family. Receptor biology is a rapidly expanding field and with the advances in cell and molecular biology and in vivo techniques, it is very likely that the field of RAMPs will explode further and many unanswered questions will be answered with in the next few years.

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Content:
Front Matter....Pages i-xvii
Introduction to Ramps....Pages 1-11
RAMPs and CGRP Receptors....Pages 13-24
Regulation of GPCR Trafficking by RAMPs....Pages 25-37
Regulation of Calcium Sensing Receptor Trafficking by RAMPs....Pages 39-48
Understanding RAMPs Through Genetically Engineered Mouse Models....Pages 49-60
RAMPs as Drug Targets....Pages 61-74
Ramp Like Proteins....Pages 75-86
Regulation of RAMP Expression in Diseases....Pages 87-103
Perspectives on Some Recent Studies on RAMPs....Pages 105-112
Back Matter....Pages 113-114

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Content:
Front Matter....Pages i-xvii
Introduction to Ramps....Pages 1-11
RAMPs and CGRP Receptors....Pages 13-24
Regulation of GPCR Trafficking by RAMPs....Pages 25-37
Regulation of Calcium Sensing Receptor Trafficking by RAMPs....Pages 39-48
Understanding RAMPs Through Genetically Engineered Mouse Models....Pages 49-60
RAMPs as Drug Targets....Pages 61-74
Ramp Like Proteins....Pages 75-86
Regulation of RAMP Expression in Diseases....Pages 87-103
Perspectives on Some Recent Studies on RAMPs....Pages 105-112
Back Matter....Pages 113-114
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