Ebook: Reprogramming Microbial Metabolic Pathways
- Tags: Biomedicine general, Microbiology, Systems Biology, Biological Techniques, Metabolomics, Applied Microbiology
- Series: Subcellular Biochemistry 64
- Year: 2012
- Publisher: Springer Netherlands
- Edition: 1
- Language: English
- pdf
Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of different metabolites. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.
Metabolic engineering has been developed over the past 20 years to become an important tool for rational engineering of microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of metabolites in microorganisms. The overall goal is to achieve a better understanding of metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.
This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation.
Metabolic engineering has been developed over the past 20 years to become an important tool for rational engineering of microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of metabolites in microorganisms. The overall goal is to achieve a better understanding of metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.
This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation.
Content:
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Towards Synthetic Gene Circuits with Enhancers: Biology’s Multi-input Integrators....Pages 3-20
Elementary Mode Analysis: A Useful Metabolic Pathway Analysis Tool for Reprograming Microbial Metabolic Pathways....Pages 21-42
Evolutionary Engineering for Industrial Microbiology....Pages 43-71
Monitoring Microbial Diversity of Bioreactors Using Metagenomic Approaches....Pages 73-94
Synthetic Biology Triggers New Era of Antibiotics Development....Pages 95-114
Cascades and Networks of Regulatory Genes That Control Antibiotic Biosynthesis....Pages 115-138
Systems Analysis of Microbial Adaptations to Simultaneous Stresses....Pages 139-157
Metabolic Reprogramming Under Microaerobic and Anaerobic Conditions in Bacteria....Pages 159-179
Tunable Promoters in Synthetic and Systems Biology....Pages 181-201
Analysis of Corynebacterium glutamicum Promoters and Their Applications....Pages 203-221
Front Matter....Pages 223-223
Production of Fumaric Acid by Fermentation....Pages 225-240
Metabolic Engineering of Microorganisms for Vitamin C Production....Pages 241-259
Molecular Mechanisms and Metabolic Engineering of Glutamate Overproduction in Corynebacterium glutamicum ....Pages 261-281
Microbial Metabolic Engineering for L-Threonine Production....Pages 283-302
The Production of Coenzyme Q10 in Microorganisms....Pages 303-326
Genetic Modification and Bioprocess Optimization for S-Adenosyl-L-methionine Biosynthesis....Pages 327-341
Manipulation of Ralstonia eutropha Carbon Storage Pathways to Produce Useful Bio-Based Products....Pages 343-366
Metabolic Engineering of Inducer Formation for Cellulase and Hemicellulase Gene Expression in Trichoderma reesei ....Pages 367-390
Microbiologically Produced Carboxylic Acids Used as Building Blocks in Organic Synthesis....Pages 391-423
Back Matter....Pages 425-441
Metabolic engineering has been developed over the past 20 years to become an important tool for rational engineering of microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of metabolites in microorganisms. The overall goal is to achieve a better understanding of metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.
This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation.
Content:
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Towards Synthetic Gene Circuits with Enhancers: Biology’s Multi-input Integrators....Pages 3-20
Elementary Mode Analysis: A Useful Metabolic Pathway Analysis Tool for Reprograming Microbial Metabolic Pathways....Pages 21-42
Evolutionary Engineering for Industrial Microbiology....Pages 43-71
Monitoring Microbial Diversity of Bioreactors Using Metagenomic Approaches....Pages 73-94
Synthetic Biology Triggers New Era of Antibiotics Development....Pages 95-114
Cascades and Networks of Regulatory Genes That Control Antibiotic Biosynthesis....Pages 115-138
Systems Analysis of Microbial Adaptations to Simultaneous Stresses....Pages 139-157
Metabolic Reprogramming Under Microaerobic and Anaerobic Conditions in Bacteria....Pages 159-179
Tunable Promoters in Synthetic and Systems Biology....Pages 181-201
Analysis of Corynebacterium glutamicum Promoters and Their Applications....Pages 203-221
Front Matter....Pages 223-223
Production of Fumaric Acid by Fermentation....Pages 225-240
Metabolic Engineering of Microorganisms for Vitamin C Production....Pages 241-259
Molecular Mechanisms and Metabolic Engineering of Glutamate Overproduction in Corynebacterium glutamicum ....Pages 261-281
Microbial Metabolic Engineering for L-Threonine Production....Pages 283-302
The Production of Coenzyme Q10 in Microorganisms....Pages 303-326
Genetic Modification and Bioprocess Optimization for S-Adenosyl-L-methionine Biosynthesis....Pages 327-341
Manipulation of Ralstonia eutropha Carbon Storage Pathways to Produce Useful Bio-Based Products....Pages 343-366
Metabolic Engineering of Inducer Formation for Cellulase and Hemicellulase Gene Expression in Trichoderma reesei ....Pages 367-390
Microbiologically Produced Carboxylic Acids Used as Building Blocks in Organic Synthesis....Pages 391-423
Back Matter....Pages 425-441
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