Ebook: Calcium Signaling

Calcium signaling contains a unique selection of chapters that cover a wide range of contemporary topics in this ubiquitous and diverse system of cell signaling. This book has the flavor of a primary text book, but it is much more than that. It covers topics ranging from the fundamental aspects of calcium signaling to its clinical implications, in a thoughtful and comprehensive way. It discusses cutting edge researches, and critical issues at depth, and it presents many testable hypotheses for future research. It includes the theoretical and the methodological topics as well as topics related to mathematical modeling, and simulations. If you want to read about calcium signaling in different mammalian cells, oocytes, Zebrafishes, and even in plants, in one and the same book, then this book will not disappoint you. From the beginners to the experts in the field of calcium signaling, everybody will find something useful in this very timely book.

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This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to oocytes, zebrafish and plants. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative.

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This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to oocytes, zebrafish and plants. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative.

Content:
Front Matter....Pages i-xiii
The Regulation of a Cell’s Ca2+ Signaling Toolkit: The Ca2+ Homeostasome....Pages 1-25
Methods to Detect Ca2+ in Living Cells....Pages 27-43
Development and Optimization of FLIPR High Throughput Calcium Assays for Ion Channels and GPCRs....Pages 45-82
Two-Photon Calcium Imaging in the Intact Brain....Pages 83-102
Signaling Through the Extracellular Calcium-Sensing Receptor (CaSR)....Pages 103-142
Ca2+ Signaling: An Outlook on the Characterization of Ca2+ Channels and Their Importance in Cellular Functions....Pages 143-157
Ryanodine Receptor Calcium Release Channels: An Evolutionary Perspective....Pages 159-182
Techniques and Methodologies to Study the Ryanodine Receptor at the Molecular, Subcellular and Cellular Level....Pages 183-215
Ryanodine Receptor Physiology and Its Role in Disease....Pages 217-234
Phospholipase C....Pages 235-254
Inositol 1,4,5-Trisphosphate and Its Receptors....Pages 255-279
The Discovery and Structural Investigation of the IP3 Receptor and the Associated IRBIT Protein....Pages 281-304
Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores....Pages 305-323
NAADP on Target....Pages 325-347
Store-Operated Ca2+ Entry....Pages 349-382
Structure, Regulation and Biophysics of ICRAC, STIM/Orai1....Pages 383-410
Mitochondria-Associated Membranes (MAMs) as Hotspot Ca2+ Signaling Units....Pages 411-437
Calcium Around the Golgi Apparatus: Implications for Intracellular Membrane Trafficking....Pages 439-460
Calcium Binding Proteins....Pages 461-482
Cytoplasmic Calcium Buffering....Pages 483-498
Elementary Calcium Release Events from the Sarcoplasmic Reticulum in the Heart....Pages 499-509
Calcium Oscillations and Pacemaking....Pages 511-520
Calcium Oscillations and Waves in Cells....Pages 521-529
Calcium Signaling: From Single Channels to Pathways....Pages 531-551
Simulation Strategies for Calcium Microdomains and Calcium-Regulated Calcium Channels....Pages 553-567
Combined Computational and Experimental Approaches to Understanding the Ca2+ Regulatory Network in Neurons....Pages 569-601
?7 Nicotinic ACh Receptors as a Ligand-Gated Source of Ca2+ Ions: The Search for a Ca2+ Optimum....Pages 603-638
The Biology of Protein Kinase C....Pages 639-661
The Role of C2 Domains in PKC Signaling....Pages 663-683
Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart....Pages 685-702
The Role of Molecular Regulation and Targeting in Regulating Calcium/Calmodulin Stimulated Protein Kinases....Pages 703-730
Calcium Sensing in Exocytosis....Pages 731-757
Regulation of Voltage-Gated Calcium Channels by Synaptic Proteins....Pages 759-775
Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels....Pages 777-794
Calcium Signaling in Vascular Smooth Muscle Cells: From Physiology to Pathology....Pages 795-810
Calcium and Endothelium-Mediated Vasodilator Signaling....Pages 811-831
Calcium Signaling in Cerebral Vasoregulation....Pages 833-858
Ca2+ Signaling Mechanisms in Bovine Adrenal Chromaffin Cells....Pages 859-872
Calcium Stores in Vertebrate Photoreceptors....Pages 873-889
Stem Cells and Calcium Signaling....Pages 891-916
Calcium Signaling in Osteoclast Differentiation and Bone Resorption....Pages 917-932
Calcium Signaling in Renal Tubular Cells....Pages 933-944
Calcium in Epidermis....Pages 945-953
Calcium Signaling in Mast Cells: Focusing on L-Type Calcium Channels....Pages 955-977
Proteinase-Activated Receptors (PARs) and Calcium Signaling in Cancer....Pages 979-1000
Mechanosensory Calcium Signaling....Pages 1001-1015
Role Ca2+ in Mechanisms of the Red Blood Cells Microrheological Changes....Pages 1017-1038
Calcium Imaging in the Zebrafish....Pages 1039-1071
Calcium Oscillations, Oocyte Activation, and Phospholipase C zeta....Pages 1073-1094
Nuclear Calcium Signaling and Its Involvement in Transcriptional Regulation in Plants....Pages 1095-1121
Remodeling of Calcium Handling in Human Heart Failure....Pages 1123-1143
Proarrhythmic Atrial Calcium Cycling in the Diseased Heart....Pages 1145-1174
Neuronal Calcium Signaling and Alzheimer’s Disease....Pages 1175-1191
Voltage-Gated Ca2+ Channel Mediated Ca2+ Influx in Epileptogenesis....Pages 1193-1217
Back Matter....Pages 1219-1247
....Pages 1249-1267