Ebook: Evolutionary Systems Biology

The book aims to introduce the reader to the emerging field of Evolutionary Systems Biology, which approaches classical systems biology questions within an evolutionary framework. An evolutionary approach might allow understanding the significance of observed diversity, uncover “evolutionary design principles” and extend predictions made in model organisms to others. In addition, evolutionary systems biology can generate new insights into the adaptive landscape by combining molecular systems biology models and evolutionary simulations. This insight can enable the development of more detailed mechanistic evolutionary hypotheses.

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The book aims to introduce the reader to the emerging field of Evolutionary Systems Biology, which approaches classical systems biology questions within an evolutionary framework. An evolutionary approach might allow understanding the significance of observed diversity, uncover “evolutionary design principles” and extend predictions made in model organisms to others. In addition, evolutionary systems biology can generate new insights into the adaptive landscape by combining molecular systems biology models and evolutionary simulations. This insight can enable the development of more detailed mechanistic evolutionary hypotheses.

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The book aims to introduce the reader to the emerging field of Evolutionary Systems Biology, which approaches classical systems biology questions within an evolutionary framework. An evolutionary approach might allow understanding the significance of observed diversity, uncover “evolutionary design principles” and extend predictions made in model organisms to others. In addition, evolutionary systems biology can generate new insights into the adaptive landscape by combining molecular systems biology models and evolutionary simulations. This insight can enable the development of more detailed mechanistic evolutionary hypotheses.
Content:
Front Matter....Pages i-x
Evolutionary Systems Biology: Historical and Philosophical Perspectives on an Emerging Synthesis....Pages 1-28
Metabolic Networks and Their Evolution....Pages 29-52
Organization Principles in Genetic Interaction Networks....Pages 53-78
Evolution of Regulatory Networks: Nematode Vulva Induction as an Example of Developmental Systems Drift....Pages 79-91
Life’s Attractors....Pages 93-119
Evolutionary Characteristics of Bacterial Two-Component Systems....Pages 121-137
Comparative Interaction Networks: Bridging Genotype to Phenotype....Pages 139-156
Evolution In Silico: From Network Structure to Bifurcation Theory....Pages 157-182
On the Search for Design Principles in Biological Systems....Pages 183-193
Toward a Theory of Multilevel Evolution: Long-Term Information Integration Shapes the Mutational Landscape and Enhances Evolvability....Pages 195-224
Evolutionary Principles Underlying Structure and Response Dynamics of Cellular Networks....Pages 225-247
Phenotypic Plasticity and Robustness: Evolutionary Stability Theory, Gene Expression Dynamics Model, and Laboratory Experiments....Pages 249-278
Genetic Redundancies and Their Evolutionary Maintenance....Pages 279-300
Evolution of Resource and Energy Management in Biologically Realistic Gene Regulatory Network Models....Pages 301-328
Reverse Ecology: From Systems to Environments and Back....Pages 329-345
Bacteria–Virus Coevolution....Pages 347-370
The Genotype–Phenotype Maps of Systems Biology and Quantitative Genetics: Distinct and Complementary....Pages 371-398
How Evolutionary Systems Biology Will Help Understand Adaptive Landscapes and Distributions of Mutational Effects....Pages 399-410
Building Synthetic Systems to Learn Nature’s Design Principles....Pages 411-429
The Robustness Continuum....Pages 431-452
Back Matter....Pages 453-455

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The book aims to introduce the reader to the emerging field of Evolutionary Systems Biology, which approaches classical systems biology questions within an evolutionary framework. An evolutionary approach might allow understanding the significance of observed diversity, uncover “evolutionary design principles” and extend predictions made in model organisms to others. In addition, evolutionary systems biology can generate new insights into the adaptive landscape by combining molecular systems biology models and evolutionary simulations. This insight can enable the development of more detailed mechanistic evolutionary hypotheses.
Content:
Front Matter....Pages i-x
Evolutionary Systems Biology: Historical and Philosophical Perspectives on an Emerging Synthesis....Pages 1-28
Metabolic Networks and Their Evolution....Pages 29-52
Organization Principles in Genetic Interaction Networks....Pages 53-78
Evolution of Regulatory Networks: Nematode Vulva Induction as an Example of Developmental Systems Drift....Pages 79-91
Life’s Attractors....Pages 93-119
Evolutionary Characteristics of Bacterial Two-Component Systems....Pages 121-137
Comparative Interaction Networks: Bridging Genotype to Phenotype....Pages 139-156
Evolution In Silico: From Network Structure to Bifurcation Theory....Pages 157-182
On the Search for Design Principles in Biological Systems....Pages 183-193
Toward a Theory of Multilevel Evolution: Long-Term Information Integration Shapes the Mutational Landscape and Enhances Evolvability....Pages 195-224
Evolutionary Principles Underlying Structure and Response Dynamics of Cellular Networks....Pages 225-247
Phenotypic Plasticity and Robustness: Evolutionary Stability Theory, Gene Expression Dynamics Model, and Laboratory Experiments....Pages 249-278
Genetic Redundancies and Their Evolutionary Maintenance....Pages 279-300
Evolution of Resource and Energy Management in Biologically Realistic Gene Regulatory Network Models....Pages 301-328
Reverse Ecology: From Systems to Environments and Back....Pages 329-345
Bacteria–Virus Coevolution....Pages 347-370
The Genotype–Phenotype Maps of Systems Biology and Quantitative Genetics: Distinct and Complementary....Pages 371-398
How Evolutionary Systems Biology Will Help Understand Adaptive Landscapes and Distributions of Mutational Effects....Pages 399-410
Building Synthetic Systems to Learn Nature’s Design Principles....Pages 411-429
The Robustness Continuum....Pages 431-452
Back Matter....Pages 453-455
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