Ebook: Behavioral Neurobiology of Aging
Author: Kathleen M. Hayden Kathleen A. Welsh-Bohmer (auth.) Marie-Christine Pardon Mark W. Bondi (eds.)
- Tags: Neurosciences, Behavioural Sciences, Geriatrics/Gerontology, Medicine/Public Health general, Quality of Life Research, Developmental Biology
- Series: Current Topics in Behavioral Neurosciences 10
- Year: 2012
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented.
The increased life expectancy seen in the past century constitutes an unprecedented economic challenge to modern societies. Public health perspectives aside, people do not want to simply live longer; they want to age successfully and remain physically and mentally active in their later years. Major advances in our understanding of brain aging and, in particular, the distinction between normal and pathological aging are required before this goal is realized. This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented. Another series of chapters specifically discuss the distinction between normal aging and Mild Cognitive Impairment, a frequent precursor of dementia, the recent advances made through both epidemiological and neuroimaging studies, and the research challenges to be addressed before we can accurately predict progression to dementia among those older adults who are at risk. The book also covers medical and psychiatric conditions, such as cerebrovascular diseases and depression, that can negatively impact cognition. It closes with a presentation of strategies to diminish and delay age-related cognitive declines, both pharmacological and non-pharmacological. This volume provides topics that will be useful to researchers, clinicians and students interested in the current knowledge and research challenges in neurobiological perspectives in aging as well as future research directions in aging research.
The increased life expectancy seen in the past century constitutes an unprecedented economic challenge to modern societies. Public health perspectives aside, people do not want to simply live longer; they want to age successfully and remain physically and mentally active in their later years. Major advances in our understanding of brain aging and, in particular, the distinction between normal and pathological aging are required before this goal is realized. This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented. Another series of chapters specifically discuss the distinction between normal aging and Mild Cognitive Impairment, a frequent precursor of dementia, the recent advances made through both epidemiological and neuroimaging studies, and the research challenges to be addressed before we can accurately predict progression to dementia among those older adults who are at risk. The book also covers medical and psychiatric conditions, such as cerebrovascular diseases and depression, that can negatively impact cognition. It closes with a presentation of strategies to diminish and delay age-related cognitive declines, both pharmacological and non-pharmacological. This volume provides topics that will be useful to researchers, clinicians and students interested in the current knowledge and research challenges in neurobiological perspectives in aging as well as future research directions in aging research.
Content:
Front Matter....Pages i-xiii
Epidemiology of Cognitive Aging and Alzheimer’s Disease: Contributions of the Cache County Utah Study of Memory, Health and Aging....Pages 3-31
Successful Cognitive Aging....Pages 35-50
Behavioral Neuroscience of Emotion in Aging....Pages 51-66
Studying the Impact of Aging on Memory Systems: Contribution of Two Behavioral Models in the Mouse....Pages 67-89
Functional Neuroimaging Studies in Normal Aging....Pages 91-111
Functional Magnetic Resonance Imaging in Aging and Dementia: Detection of Age-Related Cognitive Changes and Prediction of Cognitive Decline....Pages 113-136
Neuroanatomical Changes Associated with Cognitive Aging....Pages 137-162
The Impact of Age-Related Ovarian Hormone Loss on Cognitive and Neural Function....Pages 165-184
Neuropsychological Features of Mild Cognitive Impairment and Preclinical Alzheimer’s Disease....Pages 187-212
Cerebrovascular Disease and Cognition in Older Adults....Pages 213-241
Psychiatric Disorders in Ageing....Pages 243-269
The Impact of Physical and Mental Activity on Cognitive Aging....Pages 273-291
Potential Benefits and Limitations of Enriched Environments and Cognitive Activity on Age-Related Behavioural Decline....Pages 293-316
Reproductive Experience may Positively Adjust the Trajectory of Senescence....Pages 317-345
Treatment Trials in Aging and Mild Cognitive Impairment....Pages 347-356
Errata to: Behavioral Neurobiology of Aging....Pages E1-E1
Back Matter....Pages 357-359
The increased life expectancy seen in the past century constitutes an unprecedented economic challenge to modern societies. Public health perspectives aside, people do not want to simply live longer; they want to age successfully and remain physically and mentally active in their later years. Major advances in our understanding of brain aging and, in particular, the distinction between normal and pathological aging are required before this goal is realized. This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented. Another series of chapters specifically discuss the distinction between normal aging and Mild Cognitive Impairment, a frequent precursor of dementia, the recent advances made through both epidemiological and neuroimaging studies, and the research challenges to be addressed before we can accurately predict progression to dementia among those older adults who are at risk. The book also covers medical and psychiatric conditions, such as cerebrovascular diseases and depression, that can negatively impact cognition. It closes with a presentation of strategies to diminish and delay age-related cognitive declines, both pharmacological and non-pharmacological. This volume provides topics that will be useful to researchers, clinicians and students interested in the current knowledge and research challenges in neurobiological perspectives in aging as well as future research directions in aging research.
Content:
Front Matter....Pages i-xiii
Epidemiology of Cognitive Aging and Alzheimer’s Disease: Contributions of the Cache County Utah Study of Memory, Health and Aging....Pages 3-31
Successful Cognitive Aging....Pages 35-50
Behavioral Neuroscience of Emotion in Aging....Pages 51-66
Studying the Impact of Aging on Memory Systems: Contribution of Two Behavioral Models in the Mouse....Pages 67-89
Functional Neuroimaging Studies in Normal Aging....Pages 91-111
Functional Magnetic Resonance Imaging in Aging and Dementia: Detection of Age-Related Cognitive Changes and Prediction of Cognitive Decline....Pages 113-136
Neuroanatomical Changes Associated with Cognitive Aging....Pages 137-162
The Impact of Age-Related Ovarian Hormone Loss on Cognitive and Neural Function....Pages 165-184
Neuropsychological Features of Mild Cognitive Impairment and Preclinical Alzheimer’s Disease....Pages 187-212
Cerebrovascular Disease and Cognition in Older Adults....Pages 213-241
Psychiatric Disorders in Ageing....Pages 243-269
The Impact of Physical and Mental Activity on Cognitive Aging....Pages 273-291
Potential Benefits and Limitations of Enriched Environments and Cognitive Activity on Age-Related Behavioural Decline....Pages 293-316
Reproductive Experience may Positively Adjust the Trajectory of Senescence....Pages 317-345
Treatment Trials in Aging and Mild Cognitive Impairment....Pages 347-356
Errata to: Behavioral Neurobiology of Aging....Pages E1-E1
Back Matter....Pages 357-359
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