Ebook: RNA Metabolism in Trypanosomes

Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.

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Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.

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Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.

Content:
Front Matter....Pages i-vi
RNA Polymerases and Transcription Factors of Trypanosomes....Pages 1-27
SL RNA Biogenesis in Kinetoplastids: A Long and Winding Road....Pages 29-47
Pre-mRNA Splicing in Trypanosoma brucei: Factors, Mechanisms, and Regulation....Pages 49-77
mRNA Turnover in Trypanosomes....Pages 79-97
tRNA Biogenesis and Processing....Pages 99-121
rRNA Biogenesis in Trypanosomes....Pages 123-148
RNA Editing in African Trypanosomes: A U-ser’s G-U-ide....Pages 149-165
The RNA Interference Pathway in Trypanosoma brucei ....Pages 167-185
Translation in Trypanosomatids....Pages 187-214
Mitochondrial Translation in Trypanosomatids....Pages 215-236
RNA-Seq Analysis of the Transcriptome of Trypanosoma brucei ....Pages 237-265
Back Matter....Pages 267-271

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Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.

Content:
Front Matter....Pages i-vi
RNA Polymerases and Transcription Factors of Trypanosomes....Pages 1-27
SL RNA Biogenesis in Kinetoplastids: A Long and Winding Road....Pages 29-47
Pre-mRNA Splicing in Trypanosoma brucei: Factors, Mechanisms, and Regulation....Pages 49-77
mRNA Turnover in Trypanosomes....Pages 79-97
tRNA Biogenesis and Processing....Pages 99-121
rRNA Biogenesis in Trypanosomes....Pages 123-148
RNA Editing in African Trypanosomes: A U-ser’s G-U-ide....Pages 149-165
The RNA Interference Pathway in Trypanosoma brucei ....Pages 167-185
Translation in Trypanosomatids....Pages 187-214
Mitochondrial Translation in Trypanosomatids....Pages 215-236
RNA-Seq Analysis of the Transcriptome of Trypanosoma brucei ....Pages 237-265
Back Matter....Pages 267-271
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