Ebook: Post-Translational Modifications in Health and Disease

Post-translational modifications serve many different purposes in a wide variety of cellular processes,such as protein synthesis, folding, stability, the housing of prosthetic groups, vesicular trafficking,protein targeting to particular cell stores, exocytosis and endocytosis, the biogenesis of cell organelles and basal lamina. Signal transduction, with functional effects for enzyme regulation and metabolic control on the one hand, and gene expression, cell division, differentiation and apoptosis on the other, is also prominent. Post-translational Modifications in Health and Disease provides the reader with nineteen reviews that stimulate further investigations in the proteomic field - focusing on functional and pathological aspects of protein prenylation, the incorporation of glycosylphosphatidylinositol (GPI) moieties, oxidation, nitrosylation, glycosylation, and phosphorylation and dephosphorylation - with emphasis on their outcome for protein-protein interaction phenomena and down-stream effects. Additional chapters are devoted to protein ubiquitination, sumoylation and endoplasmic reticulum-associated degradation (ERAD), the influence of histone modification on gene expression and DNA repair, and proteolytic processing of intracellular and basal lamina proteins. This book will be of particular significance to researchers, clinicians, and students of biology, pharmacy and medicine.

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Post-translational modifications serve many different purposes in a wide variety of cellular processes,such as protein synthesis, folding, stability, the housing of prosthetic groups, vesicular trafficking,protein targeting to particular cell stores, exocytosis and endocytosis, the biogenesis of cell organelles and basal lamina. Signal transduction, with functional effects for enzyme regulation and metabolic control on the one hand, and gene expression, cell division, differentiation and apoptosis on the other, is also prominent. Post-translational Modifications in Health and Disease provides the reader with nineteen reviews that stimulate further investigations in the proteomic field - focusing on functional and pathological aspects of protein prenylation, the incorporation of glycosylphosphatidylinositol (GPI) moieties, oxidation, nitrosylation, glycosylation, and phosphorylation and dephosphorylation - with emphasis on their outcome for protein-protein interaction phenomena and down-stream effects. Additional chapters are devoted to protein ubiquitination, sumoylation and endoplasmic reticulum-associated degradation (ERAD), the influence of histone modification on gene expression and DNA repair, and proteolytic processing of intracellular and basal lamina proteins. This book will be of particular significance to researchers, clinicians, and students of biology, pharmacy and medicine.

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Post-translational modifications serve many different purposes in a wide variety of cellular processes,such as protein synthesis, folding, stability, the housing of prosthetic groups, vesicular trafficking,protein targeting to particular cell stores, exocytosis and endocytosis, the biogenesis of cell organelles and basal lamina. Signal transduction, with functional effects for enzyme regulation and metabolic control on the one hand, and gene expression, cell division, differentiation and apoptosis on the other, is also prominent. Post-translational Modifications in Health and Disease provides the reader with nineteen reviews that stimulate further investigations in the proteomic field - focusing on functional and pathological aspects of protein prenylation, the incorporation of glycosylphosphatidylinositol (GPI) moieties, oxidation, nitrosylation, glycosylation, and phosphorylation and dephosphorylation - with emphasis on their outcome for protein-protein interaction phenomena and down-stream effects. Additional chapters are devoted to protein ubiquitination, sumoylation and endoplasmic reticulum-associated degradation (ERAD), the influence of histone modification on gene expression and DNA repair, and proteolytic processing of intracellular and basal lamina proteins. This book will be of particular significance to researchers, clinicians, and students of biology, pharmacy and medicine.
Content:
Front Matter....Pages i-xiii
Isoprenoid Modifications....Pages 1-37
GPI-Anchored Proteins in Health and Disease....Pages 39-55
Protein Oxidation....Pages 57-78
Involvement of S-Nitrosylation in Neurodegeneration....Pages 79-95
Protein Glysosylation and Congenital Disorders of Glycosylation....Pages 97-117
Defective Glycosylation of Dystroglycan in Muscular Dystrophy and Cancer....Pages 119-143
Protein Kinase A: The Enzyme and Cyclic AMP Signaling....Pages 145-169
The Protein Kinase C Family: Key Regulators Bridging Signaling Pathways in Skin and Tumor Epithelia....Pages 171-198
Maintaining Energy Balance in Health and Disease: Role of the AMP-Activated Protein Kinase....Pages 199-232
Protein Phosphatases in the Brain: Regulation, Function and Disease....Pages 233-257
Covalent Protein Modification as a Mechanism for Dynamic Recruitment of Specific Interactors....Pages 259-279
Regulation of Gene Expression by the Ubiquitin–Proteasome System and Implications for Neurological Disease....Pages 281-315
Small Ubiquitin-Like Modifiers and Other Ubiquitin-Like Proteins....Pages 317-340
ER-associated Degradation and Its Involvement in Human Disease: Insights from Yeast....Pages 341-364
Regulation of Chromatin Structure and Transcription Via Histone Modifications....Pages 365-385
Chromatin: The Entry to and Exit from DNA Repair....Pages 387-409
Poly(ADP-Ribosyl)ation of Chromosomal Proteins, Epigenetic Regulation and Human Genomic Integrity in Health and Disease....Pages 411-424
Post-translational Proteolytic Processing on Intracellular Proteins by Cathepsins and Cystatins....Pages 425-456
Metalloproteases and Proteolytic Processing....Pages 457-482
Back Matter....Pages 483-486

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Post-translational modifications serve many different purposes in a wide variety of cellular processes,such as protein synthesis, folding, stability, the housing of prosthetic groups, vesicular trafficking,protein targeting to particular cell stores, exocytosis and endocytosis, the biogenesis of cell organelles and basal lamina. Signal transduction, with functional effects for enzyme regulation and metabolic control on the one hand, and gene expression, cell division, differentiation and apoptosis on the other, is also prominent. Post-translational Modifications in Health and Disease provides the reader with nineteen reviews that stimulate further investigations in the proteomic field - focusing on functional and pathological aspects of protein prenylation, the incorporation of glycosylphosphatidylinositol (GPI) moieties, oxidation, nitrosylation, glycosylation, and phosphorylation and dephosphorylation - with emphasis on their outcome for protein-protein interaction phenomena and down-stream effects. Additional chapters are devoted to protein ubiquitination, sumoylation and endoplasmic reticulum-associated degradation (ERAD), the influence of histone modification on gene expression and DNA repair, and proteolytic processing of intracellular and basal lamina proteins. This book will be of particular significance to researchers, clinicians, and students of biology, pharmacy and medicine.
Content:
Front Matter....Pages i-xiii
Isoprenoid Modifications....Pages 1-37
GPI-Anchored Proteins in Health and Disease....Pages 39-55
Protein Oxidation....Pages 57-78
Involvement of S-Nitrosylation in Neurodegeneration....Pages 79-95
Protein Glysosylation and Congenital Disorders of Glycosylation....Pages 97-117
Defective Glycosylation of Dystroglycan in Muscular Dystrophy and Cancer....Pages 119-143
Protein Kinase A: The Enzyme and Cyclic AMP Signaling....Pages 145-169
The Protein Kinase C Family: Key Regulators Bridging Signaling Pathways in Skin and Tumor Epithelia....Pages 171-198
Maintaining Energy Balance in Health and Disease: Role of the AMP-Activated Protein Kinase....Pages 199-232
Protein Phosphatases in the Brain: Regulation, Function and Disease....Pages 233-257
Covalent Protein Modification as a Mechanism for Dynamic Recruitment of Specific Interactors....Pages 259-279
Regulation of Gene Expression by the Ubiquitin–Proteasome System and Implications for Neurological Disease....Pages 281-315
Small Ubiquitin-Like Modifiers and Other Ubiquitin-Like Proteins....Pages 317-340
ER-associated Degradation and Its Involvement in Human Disease: Insights from Yeast....Pages 341-364
Regulation of Chromatin Structure and Transcription Via Histone Modifications....Pages 365-385
Chromatin: The Entry to and Exit from DNA Repair....Pages 387-409
Poly(ADP-Ribosyl)ation of Chromosomal Proteins, Epigenetic Regulation and Human Genomic Integrity in Health and Disease....Pages 411-424
Post-translational Proteolytic Processing on Intracellular Proteins by Cathepsins and Cystatins....Pages 425-456
Metalloproteases and Proteolytic Processing....Pages 457-482
Back Matter....Pages 483-486
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