Ebook: Mechanosensitivity and Mechanotransduction

This book presents the latest findings in the field of research of mechanosensitivity and
mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction
of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and
extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K⁺ channels functioning in mouse B lymphocytes.

This book is a unique collection of reviews outlining current knowledge and future developments
in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of
studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies.

This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

This book presents the latest findings in the field of research of mechanosensitivity and
mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction
of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and
extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K⁺ channels functioning in mouse B lymphocytes.

This book is a unique collection of reviews outlining current knowledge and future developments
in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of
studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies.

This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

This book presents the latest findings in the field of research of mechanosensitivity and
mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction
of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and
extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K⁺ channels functioning in mouse B lymphocytes.

This book is a unique collection of reviews outlining current knowledge and future developments
in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of
studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies.

This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Content:
Front Matter....Pages i-xxiv
Front Matter....Pages 1-1
Integrin-Mediated Mechanotransduction in Vascular Smooth Muscle Cells....Pages 3-24
The Role of the Actin Cytoskeleton in Mechanosensation....Pages 25-65
Effect of Cytoskeleton on the Mechanosensitivity of Genes in Osteoblasts....Pages 67-76
Involvement of the Cytoskeletal Elements in Articular Cartilage Mechanotransduction....Pages 77-106
Front Matter....Pages 107-107
The Role of Nitric Oxide in the Regulation of Mechanically Gated Channels in the Heart....Pages 109-140
Role of Signaling Pathways in the Myocardial Response to Biomechanical Stress and in Mechanotransduction in the Heart....Pages 141-166
Atomistic Molecular Simulation of Gating Modifier Venom Peptides – Two Binding Modes and Effects of Lipid Structure....Pages 167-190
Front Matter....Pages 191-191
Cellular and Molecular Effects of Mechanical Stretch on Vascular Cells....Pages 193-217
Role of Proteoglycans in Vascular Mechanotransduction....Pages 219-236
Front Matter....Pages 237-237
Control of TRPV4 and Its Effect on the Lung....Pages 239-254
The Role of Protein-protein Interactions in Mechanotransduction: Implications in Ventilator Induced Lung Injury....Pages 255-273
Front Matter....Pages 275-275
Cellular Mechanisms of Mechanotransduction in Bone....Pages 277-296
The Mechanosensitivity of Cells in Joint Tissues: Role in the Pathogenesis of Joint Diseases....Pages 297-313
Front Matter....Pages 315-315
Primary Cilia are Mechanosensory Organelles in Vestibular Tissues....Pages 317-350
Front Matter....Pages 351-351
Mechanosensitive K+ Channels in Mouse B Lymphocytes: PLC-Mediated Release of TREK-2 from Inhibition by PIP2 ....Pages 353-368
Back Matter....Pages 369-371

This book presents the latest findings in the field of research of mechanosensitivity and
mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction
of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and
extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K⁺ channels functioning in mouse B lymphocytes.

This book is a unique collection of reviews outlining current knowledge and future developments
in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of
studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies.

This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Content:
Front Matter....Pages i-xxiv
Front Matter....Pages 1-1
Integrin-Mediated Mechanotransduction in Vascular Smooth Muscle Cells....Pages 3-24
The Role of the Actin Cytoskeleton in Mechanosensation....Pages 25-65
Effect of Cytoskeleton on the Mechanosensitivity of Genes in Osteoblasts....Pages 67-76
Involvement of the Cytoskeletal Elements in Articular Cartilage Mechanotransduction....Pages 77-106
Front Matter....Pages 107-107
The Role of Nitric Oxide in the Regulation of Mechanically Gated Channels in the Heart....Pages 109-140
Role of Signaling Pathways in the Myocardial Response to Biomechanical Stress and in Mechanotransduction in the Heart....Pages 141-166
Atomistic Molecular Simulation of Gating Modifier Venom Peptides – Two Binding Modes and Effects of Lipid Structure....Pages 167-190
Front Matter....Pages 191-191
Cellular and Molecular Effects of Mechanical Stretch on Vascular Cells....Pages 193-217
Role of Proteoglycans in Vascular Mechanotransduction....Pages 219-236
Front Matter....Pages 237-237
Control of TRPV4 and Its Effect on the Lung....Pages 239-254
The Role of Protein-protein Interactions in Mechanotransduction: Implications in Ventilator Induced Lung Injury....Pages 255-273
Front Matter....Pages 275-275
Cellular Mechanisms of Mechanotransduction in Bone....Pages 277-296
The Mechanosensitivity of Cells in Joint Tissues: Role in the Pathogenesis of Joint Diseases....Pages 297-313
Front Matter....Pages 315-315
Primary Cilia are Mechanosensory Organelles in Vestibular Tissues....Pages 317-350
Front Matter....Pages 351-351
Mechanosensitive K+ Channels in Mouse B Lymphocytes: PLC-Mediated Release of TREK-2 from Inhibition by PIP2 ....Pages 353-368
Back Matter....Pages 369-371
....