Ebook: Intracellular Delivery: Fundamentals and Applications

This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly existing conservative practices.

This volume is a collection of authoritative reviews. In the introductory part we define the field (intracellular delivery). Then, we first we cover fundamental routes of nanodelivery devices cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; all at academic and applied levels. Following is dedicated to enhancing delivery via special targeting motifs. Second, we introduce different types of intracellular nanodelivery devices (their chemistry, although the coverage is far from complete) and ways of producing these different devices. Third, we put special emphasis on particular disease states and on other biomedical applications. Diagnostic and sensing is also included.

The intracellular delivery/therapy is a very pregnant topic which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is a great potential for targeted delivery with improved localized delivery and efficacy.

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This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly existing conservative practices.

This volume is a collection of authoritative reviews. In the introductory part we define the field (intracellular delivery). Then, we first we cover fundamental routes of nanodelivery devices cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; all at academic and applied levels. Following is dedicated to enhancing delivery via special targeting motifs. Second, we introduce different types of intracellular nanodelivery devices (their chemistry, although the coverage is far from complete) and ways of producing these different devices. Third, we put special emphasis on particular disease states and on other biomedical applications. Diagnostic and sensing is also included.

The intracellular delivery/therapy is a very pregnant topic which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is a great potential for targeted delivery with improved localized delivery and efficacy.

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This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly existing conservative practices.

This volume is a collection of authoritative reviews. In the introductory part we define the field (intracellular delivery). Then, we first we cover fundamental routes of nanodelivery devices cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; all at academic and applied levels. Following is dedicated to enhancing delivery via special targeting motifs. Second, we introduce different types of intracellular nanodelivery devices (their chemistry, although the coverage is far from complete) and ways of producing these different devices. Third, we put special emphasis on particular disease states and on other biomedical applications. Diagnostic and sensing is also included.

The intracellular delivery/therapy is a very pregnant topic which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is a great potential for targeted delivery with improved localized delivery and efficacy.

Content:
Front Matter....Pages i-xix
Front Matter....Pages 1-1
Mass Transport via Cellular Barriers and Endocytosis....Pages 3-55
Approaches to Achieving Sub-cellular Targeting of Bioactives Using Pharmaceutical Nanocarriers....Pages 57-72
Delivery to Intracellular Targets by Nanosized Particles....Pages 73-95
The Potential and Current Progress of Internalizing Molecules in Targeted Drug Delivery....Pages 97-123
Simulation Based Analysis of Nanocarrier Internalization: Exciting Challenges with a New Computational Tool....Pages 125-154
Nanosized Drug Delivery Vectors and the Reticuloendothelial System....Pages 155-178
Membrane Crossover by Cell-Penetrating Peptides: Kinetics and Mechanisms – From Model to Cell Membrane Perturbation by Permeant Peptides....Pages 179-196
Front Matter....Pages 197-197
Intracellular Delivery: A Multifunctional and Modular Approach....Pages 199-223
Poly(Alkyl Cyanoacrylate) Nanosystems....Pages 225-250
Amphiphilic Block Copolymer Based Nanocarriers for Drug and Gene Delivery....Pages 251-289
Stimuli-Responsive Polymersomes....Pages 291-331
Silica-Based Nanoparticles for Intracellular Drug Delivery....Pages 333-361
Magnetic Nanoparticles for Biomedicine....Pages 363-372
Biosynthesis of Metallic Nanoparticles and Their Applications....Pages 373-409
Nanocrystals: Production, Cellular Drug Delivery, Current and Future Products....Pages 411-432
Processing and Scale-up of Polymeric Nanoparticles....Pages 433-456
Front Matter....Pages 457-457
Magnetic Resonance Tracking of Stem Cells with Iron Oxide Particles....Pages 459-485
Nanoparticles for the Oral Administration of Cancer Therapies....Pages 487-509
Nanoparticles for Photodynamic Therapy Applications....Pages 511-565
Nanoparticles Enhanced Hyperthermia....Pages 567-598
Front Matter....Pages 457-457
Non-viral Gene Therapy....Pages 599-699
Imaging of Nanoparticle Delivery Using Terahertz Waves....Pages 701-711
Calcium Phosphate and Calcium Phosphosilicate Mediated Drug Delivery and Imaging....Pages 713-744
Intracellular Bacteria and Protozoa....Pages 745-811
Gene Therapy in Bone Regeneration: A Summary of Delivery Approaches for Effective Therapies....Pages 813-846
Nanoinformatics: Developing Advanced Informatics Applications for Nanomedicine....Pages 847-860
Back Matter....Pages 861-867

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This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly existing conservative practices.

This volume is a collection of authoritative reviews. In the introductory part we define the field (intracellular delivery). Then, we first we cover fundamental routes of nanodelivery devices cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; all at academic and applied levels. Following is dedicated to enhancing delivery via special targeting motifs. Second, we introduce different types of intracellular nanodelivery devices (their chemistry, although the coverage is far from complete) and ways of producing these different devices. Third, we put special emphasis on particular disease states and on other biomedical applications. Diagnostic and sensing is also included.

The intracellular delivery/therapy is a very pregnant topic which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is a great potential for targeted delivery with improved localized delivery and efficacy.

Content:
Front Matter....Pages i-xix
Front Matter....Pages 1-1
Mass Transport via Cellular Barriers and Endocytosis....Pages 3-55
Approaches to Achieving Sub-cellular Targeting of Bioactives Using Pharmaceutical Nanocarriers....Pages 57-72
Delivery to Intracellular Targets by Nanosized Particles....Pages 73-95
The Potential and Current Progress of Internalizing Molecules in Targeted Drug Delivery....Pages 97-123
Simulation Based Analysis of Nanocarrier Internalization: Exciting Challenges with a New Computational Tool....Pages 125-154
Nanosized Drug Delivery Vectors and the Reticuloendothelial System....Pages 155-178
Membrane Crossover by Cell-Penetrating Peptides: Kinetics and Mechanisms – From Model to Cell Membrane Perturbation by Permeant Peptides....Pages 179-196
Front Matter....Pages 197-197
Intracellular Delivery: A Multifunctional and Modular Approach....Pages 199-223
Poly(Alkyl Cyanoacrylate) Nanosystems....Pages 225-250
Amphiphilic Block Copolymer Based Nanocarriers for Drug and Gene Delivery....Pages 251-289
Stimuli-Responsive Polymersomes....Pages 291-331
Silica-Based Nanoparticles for Intracellular Drug Delivery....Pages 333-361
Magnetic Nanoparticles for Biomedicine....Pages 363-372
Biosynthesis of Metallic Nanoparticles and Their Applications....Pages 373-409
Nanocrystals: Production, Cellular Drug Delivery, Current and Future Products....Pages 411-432
Processing and Scale-up of Polymeric Nanoparticles....Pages 433-456
Front Matter....Pages 457-457
Magnetic Resonance Tracking of Stem Cells with Iron Oxide Particles....Pages 459-485
Nanoparticles for the Oral Administration of Cancer Therapies....Pages 487-509
Nanoparticles for Photodynamic Therapy Applications....Pages 511-565
Nanoparticles Enhanced Hyperthermia....Pages 567-598
Front Matter....Pages 457-457
Non-viral Gene Therapy....Pages 599-699
Imaging of Nanoparticle Delivery Using Terahertz Waves....Pages 701-711
Calcium Phosphate and Calcium Phosphosilicate Mediated Drug Delivery and Imaging....Pages 713-744
Intracellular Bacteria and Protozoa....Pages 745-811
Gene Therapy in Bone Regeneration: A Summary of Delivery Approaches for Effective Therapies....Pages 813-846
Nanoinformatics: Developing Advanced Informatics Applications for Nanomedicine....Pages 847-860
Back Matter....Pages 861-867
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