Ebook: Influenza Vaccines for the Future

The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.

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The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.

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The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.
Content:
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Influenza Virus: The Biology of a Changing Virus....Pages 3-26
The Epidemiology of Influenza and Its Control....Pages 27-54
Epidemiology of Influenza in Tropical and Subtropical Low-Income Regions....Pages 55-75
The Origin and Evolution of H1N1 Pandemic Influenza Viruses....Pages 77-93
The Emergence of 2009 H1N1 Pandemic Influenza....Pages 95-111
Front Matter....Pages 113-113
Influenza Vaccines Have a Short but Illustrious History of Dedicated Science Enabling the Rapid Global Production of A/Swine (H1N1) Vaccine in the Current Pandemic....Pages 115-147
Influenza and Influenza Vaccination in Children....Pages 149-171
The Immune Response to Influenza A Viruses....Pages 173-197
Correlates of Protection Against Influenza....Pages 199-222
The Role of Animal Models In Influenza Vaccine Research....Pages 223-272
Live Attenuated Influenza Vaccine....Pages 273-291
Cell Culture-Derived Influenza Vaccines....Pages 293-312
Conserved Internal Proteins as Potential Universal Vaccines....Pages 313-325
Emulsion-Based Adjuvants for Improved Influenza Vaccines....Pages 327-357
Lessons Learned from Clinical Trials in 1976 and 1977 of Vaccines for the Newly Emerged Swine and Russian Influenza A/H1N1 Viruses....Pages 359-371
Occurrences of the Guillain–Barre Syndrome (GBS) After Vaccinations with the 1976 Swine A/H1N1 Vaccine, and Evolution of the Concern for an Influenza Vaccine-GBS Association....Pages 373-382
Human Monoclonal Antibodies for Prophylaxis and Treatment of Influenza....Pages 383-398
Front Matter....Pages 399-399
Learning from the First Pandemic of the Twenty-First Century....Pages 401-423
Economic Implications of Influenza and Influenza Vaccine....Pages 425-440
Back Matter....Pages 441-446

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The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.
Content:
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Influenza Virus: The Biology of a Changing Virus....Pages 3-26
The Epidemiology of Influenza and Its Control....Pages 27-54
Epidemiology of Influenza in Tropical and Subtropical Low-Income Regions....Pages 55-75
The Origin and Evolution of H1N1 Pandemic Influenza Viruses....Pages 77-93
The Emergence of 2009 H1N1 Pandemic Influenza....Pages 95-111
Front Matter....Pages 113-113
Influenza Vaccines Have a Short but Illustrious History of Dedicated Science Enabling the Rapid Global Production of A/Swine (H1N1) Vaccine in the Current Pandemic....Pages 115-147
Influenza and Influenza Vaccination in Children....Pages 149-171
The Immune Response to Influenza A Viruses....Pages 173-197
Correlates of Protection Against Influenza....Pages 199-222
The Role of Animal Models In Influenza Vaccine Research....Pages 223-272
Live Attenuated Influenza Vaccine....Pages 273-291
Cell Culture-Derived Influenza Vaccines....Pages 293-312
Conserved Internal Proteins as Potential Universal Vaccines....Pages 313-325
Emulsion-Based Adjuvants for Improved Influenza Vaccines....Pages 327-357
Lessons Learned from Clinical Trials in 1976 and 1977 of Vaccines for the Newly Emerged Swine and Russian Influenza A/H1N1 Viruses....Pages 359-371
Occurrences of the Guillain–Barre Syndrome (GBS) After Vaccinations with the 1976 Swine A/H1N1 Vaccine, and Evolution of the Concern for an Influenza Vaccine-GBS Association....Pages 373-382
Human Monoclonal Antibodies for Prophylaxis and Treatment of Influenza....Pages 383-398
Front Matter....Pages 399-399
Learning from the First Pandemic of the Twenty-First Century....Pages 401-423
Economic Implications of Influenza and Influenza Vaccine....Pages 425-440
Back Matter....Pages 441-446
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