Ebook: Biofilm Infections

There has been an increasing interest and emphasis on the sessile bacterial lifestyle biofilms since it was discovered that the vast majority of the total microbial biomass exists as biofilms. Leeuwenhoek first described the aggregation of bacteria in 1677, but it was only recently recognized as being important in chronic infection. In 1993, the American Society for Microbiology (ASM) recognized that the biofilm mode of growth was relevant to microbiology. This book covers both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics, pathogenesis, treatment regimes, and in vitro and in vivo models for studying biofilms. This is the first scientific book on biofilm infections, with chapters written by world- renowned scientists and clinicians. The intended audience of this book includes scientists, teachers at the university level, as well as clinicians. About the Editors: Thomas Bjarnsholt, Ph.D., Technical University of Denmark, Lyngby, Denmark Peter Oestrup Jensen, Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark Claus Moser, Ph.D., Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark Niels Hoeby, Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark

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There has been an increasing interest and emphasis on the sessile bacterial lifestyle biofilms since it was discovered that the vast majority of the total microbial biomass exists as biofilms. Leeuwenhoek first described the aggregation of bacteria in 1677, but it was only recently recognized as being important in chronic infection. In 1993, the American Society for Microbiology (ASM) recognized that the biofilm mode of growth was relevant to microbiology. This book covers both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics, pathogenesis, treatment regimes, and in vitro and in vivo models for studying biofilms. This is the first scientific book on biofilm infections, with chapters written by world- renowned scientists and clinicians. The intended audience of this book includes scientists, teachers at the university level, as well as clinicians. About the Editors: Thomas Bjarnsholt, Ph.D., Technical University of Denmark, Lyngby, Denmark Peter Oestrup Jensen, Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark Claus Moser, Ph.D., Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark Niels Hoeby, Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark

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There has been an increasing interest and emphasis on the sessile bacterial lifestyle biofilms since it was discovered that the vast majority of the total microbial biomass exists as biofilms. Leeuwenhoek first described the aggregation of bacteria in 1677, but it was only recently recognized as being important in chronic infection. In 1993, the American Society for Microbiology (ASM) recognized that the biofilm mode of growth was relevant to microbiology. This book covers both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics, pathogenesis, treatment regimes, and in vitro and in vivo models for studying biofilms. This is the first scientific book on biofilm infections, with chapters written by world- renowned scientists and clinicians. The intended audience of this book includes scientists, teachers at the university level, as well as clinicians. About the Editors: Thomas Bjarnsholt, Ph.D., Technical University of Denmark, Lyngby, Denmark Peter Oestrup Jensen, Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark Claus Moser, Ph.D., Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark Niels Hoeby, Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
Content:
Front Matter....Pages i-xiv
Introduction to Biofilms....Pages 1-9
Chronic Wound Colonization, Infection, and Biofilms....Pages 11-24
The Relation of Biofilms to Chronic Otitis Media and Other Ear-Related Chronic Infections....Pages 25-34
Human Oral Bacterial Biofilms: Composition, Dynamics, and Pathogenesis....Pages 35-68
Implant-Associated Infection....Pages 69-90
The Role of Bacterial Biofilms in Infections of Catheters and Shunts....Pages 91-109
Osteomyelitis....Pages 111-137
The Importance of Biofilms in Chronic Rhinosinusitis....Pages 139-160
Helicobacter pylori and Biofilm Formation....Pages 161-166
Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients....Pages 167-184
Innate Immune Response to Infectious Biofilms....Pages 185-200
Adaptive Immune Responses and Biofilm Infections....Pages 201-214
Antibiotic Tolerance and Resistance in Biofilms....Pages 215-229
Novel and Future Treatment Strategies....Pages 231-249
Different Methods for Culturing Biofilms In Vitro....Pages 251-266
In Vivo Models of Biofilm Infection....Pages 267-290
Summary and Perspectives....Pages 291-294
Back Matter....Pages 295-314

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There has been an increasing interest and emphasis on the sessile bacterial lifestyle biofilms since it was discovered that the vast majority of the total microbial biomass exists as biofilms. Leeuwenhoek first described the aggregation of bacteria in 1677, but it was only recently recognized as being important in chronic infection. In 1993, the American Society for Microbiology (ASM) recognized that the biofilm mode of growth was relevant to microbiology. This book covers both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics, pathogenesis, treatment regimes, and in vitro and in vivo models for studying biofilms. This is the first scientific book on biofilm infections, with chapters written by world- renowned scientists and clinicians. The intended audience of this book includes scientists, teachers at the university level, as well as clinicians. About the Editors: Thomas Bjarnsholt, Ph.D., Technical University of Denmark, Lyngby, Denmark Peter Oestrup Jensen, Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark Claus Moser, Ph.D., Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark Niels Hoeby, Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
Content:
Front Matter....Pages i-xiv
Introduction to Biofilms....Pages 1-9
Chronic Wound Colonization, Infection, and Biofilms....Pages 11-24
The Relation of Biofilms to Chronic Otitis Media and Other Ear-Related Chronic Infections....Pages 25-34
Human Oral Bacterial Biofilms: Composition, Dynamics, and Pathogenesis....Pages 35-68
Implant-Associated Infection....Pages 69-90
The Role of Bacterial Biofilms in Infections of Catheters and Shunts....Pages 91-109
Osteomyelitis....Pages 111-137
The Importance of Biofilms in Chronic Rhinosinusitis....Pages 139-160
Helicobacter pylori and Biofilm Formation....Pages 161-166
Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients....Pages 167-184
Innate Immune Response to Infectious Biofilms....Pages 185-200
Adaptive Immune Responses and Biofilm Infections....Pages 201-214
Antibiotic Tolerance and Resistance in Biofilms....Pages 215-229
Novel and Future Treatment Strategies....Pages 231-249
Different Methods for Culturing Biofilms In Vitro....Pages 251-266
In Vivo Models of Biofilm Infection....Pages 267-290
Summary and Perspectives....Pages 291-294
Back Matter....Pages 295-314
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