Ebook: Oxidative Stress and Free Radical Damage in Neurology

The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.

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The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.

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The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.
Content:
Front Matter....Pages i-viii
The Role of Free Radicals in the Nervous System....Pages 1-17
Why Is the Nervous System Vulnerable to Oxidative Stress?....Pages 19-27
Perinatal Hypoxic-Ischemic Neural Injury and Free Radical Injury: A Fine Balance....Pages 29-46
Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy....Pages 47-63
Oxidative Stress in Multiple Sclerosis Pathology and Therapeutic Potential of Nrf2 Activation....Pages 65-77
Free Radicals in Central Nervous System Inflammation....Pages 79-98
The Role of Reactive Oxygen Species in the Pathogenesis of Traumatic Brain Injury....Pages 99-118
Distinct Roles of Cyclooxygenase-1 and Cyclooxygenase-2 in Inflammatory and Excitotoxic Brain Injury....Pages 119-136
Stroke and Oxidative Stress....Pages 137-152
Free Radicals in Epilepsy....Pages 153-167
Neurological Disorders Associated with Iron Misdistribution: The Therapeutic Potential of Siderophores....Pages 169-190
Oxidative Stress in Parkinson's Disease....Pages 191-223
Tetrahydrobiopterin Deficiency....Pages 225-234
Radicals Attack the Ear The Toll: A Loss of Hearing....Pages 235-252
Reactive Oxygen Species in Mitochondrial Encephalomyopathy: Mechanisms and Effects....Pages 253-292
Potential Role of Oxidative Damage in Neurological Manifestations of Acute Intermittent Porphyria....Pages 293-311
Back Matter....Pages 313-323

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The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.
Content:
Front Matter....Pages i-viii
The Role of Free Radicals in the Nervous System....Pages 1-17
Why Is the Nervous System Vulnerable to Oxidative Stress?....Pages 19-27
Perinatal Hypoxic-Ischemic Neural Injury and Free Radical Injury: A Fine Balance....Pages 29-46
Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy....Pages 47-63
Oxidative Stress in Multiple Sclerosis Pathology and Therapeutic Potential of Nrf2 Activation....Pages 65-77
Free Radicals in Central Nervous System Inflammation....Pages 79-98
The Role of Reactive Oxygen Species in the Pathogenesis of Traumatic Brain Injury....Pages 99-118
Distinct Roles of Cyclooxygenase-1 and Cyclooxygenase-2 in Inflammatory and Excitotoxic Brain Injury....Pages 119-136
Stroke and Oxidative Stress....Pages 137-152
Free Radicals in Epilepsy....Pages 153-167
Neurological Disorders Associated with Iron Misdistribution: The Therapeutic Potential of Siderophores....Pages 169-190
Oxidative Stress in Parkinson's Disease....Pages 191-223
Tetrahydrobiopterin Deficiency....Pages 225-234
Radicals Attack the Ear The Toll: A Loss of Hearing....Pages 235-252
Reactive Oxygen Species in Mitochondrial Encephalomyopathy: Mechanisms and Effects....Pages 253-292
Potential Role of Oxidative Damage in Neurological Manifestations of Acute Intermittent Porphyria....Pages 293-311
Back Matter....Pages 313-323
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