Ebook: Ribonuclease P
- Tags: Proteomics
- Series: Protein Reviews 10
- Year: 2010
- Publisher: Springer-Verlag New York
- Edition: 1
- Language: English
- pdf
Ribonuclease P (RNaseP), a ribonucleoprotein, is an essential tRNA processing enzyme found in all living organisms. Since its discovery almost 40 years ago, research on RNase P has led to the discovery of the catalytic properties of RNA, and of the only known, naturally occurring RNA enzymes, RNase P catalytic RNA. The description of the catalytic properties of RNA has provided fundamental insight into the RNA world and these catalytic properties are being harnessed as therapeutic and prevention strategies for acquired and inherited diseases. Ribonuclease P is the first book to provide a comprehensive collection covering all aspects of current research on RNase P. The topics include kinetic and structural analysis, mechanism of catalysis, and its regulation and biogenesis in prokaryotes, eukaryotes, and organelles. Furthermore, research progresses on developing RNase P as a potential drug target for antimicrobial development and as a gene-targeting tool for anti-infective and anticancer therapy are also included. This book should be of general interests to molecular biologists and biochemists in both the academic section and pharmaceutical industry.
Ribonuclease P (RNaseP), a ribonucleoprotein, is an essential tRNA processing enzyme found in all living organisms. Since its discovery almost 40 years ago, research on RNase P has led to the discovery of the catalytic properties of RNA, and of the only known, naturally occurring RNA enzymes, RNase P catalytic RNA. The description of the catalytic properties of RNA has provided fundamental insight into the RNA world and these catalytic properties are being harnessed as therapeutic and prevention strategies for acquired and inherited diseases. Ribonuclease P is the first book to provide a comprehensive collection covering all aspects of current research on RNase P. The topics include kinetic and structural analysis, mechanism of catalysis, and its regulation and biogenesis in prokaryotes, eukaryotes, and organelles. Furthermore, research progresses on developing RNase P as a potential drug target for antimicrobial development and as a gene-targeting tool for anti-infective and anticancer therapy are also included. This book should be of general interests to molecular biologists and biochemists in both the academic section and pharmaceutical industry.
Ribonuclease P (RNaseP), a ribonucleoprotein, is an essential tRNA processing enzyme found in all living organisms. Since its discovery almost 40 years ago, research on RNase P has led to the discovery of the catalytic properties of RNA, and of the only known, naturally occurring RNA enzymes, RNase P catalytic RNA. The description of the catalytic properties of RNA has provided fundamental insight into the RNA world and these catalytic properties are being harnessed as therapeutic and prevention strategies for acquired and inherited diseases. Ribonuclease P is the first book to provide a comprehensive collection covering all aspects of current research on RNase P. The topics include kinetic and structural analysis, mechanism of catalysis, and its regulation and biogenesis in prokaryotes, eukaryotes, and organelles. Furthermore, research progresses on developing RNase P as a potential drug target for antimicrobial development and as a gene-targeting tool for anti-infective and anticancer therapy are also included. This book should be of general interests to molecular biologists and biochemists in both the academic section and pharmaceutical industry.
Content:
Front Matter....Pages i-xiv
History of RNase P and Overview of Its Catalytic Activity....Pages 1-15
The Evolution of RNase P and Its RNA....Pages 17-40
Over a Decade of Bacterial Ribonuclease P Modeling....Pages 41-62
Structural Studies of Ribonuclease P....Pages 63-78
Folding of Bacterial RNase P RNA....Pages 79-91
Kinetic Mechanism of Bacterial RNase P....Pages 93-111
Roles of Metal Ions in RNase P Catalysis....Pages 113-134
Challenges in RNase P Substrate Recognition: Considering the Biological Context....Pages 135-151
Archaeal RNase P: A Mosaic of Its Bacterial and Eukaryal Relatives....Pages 153-172
Eukaryote RNase P and RNase MRP....Pages 173-202
RNase P from Organelles....Pages 203-222
Human RNase P and Transcription....Pages 223-234
RNase P as a Drug Target....Pages 235-256
Ribonuclease P as a Tool....Pages 257-275
Back Matter....Pages 227-283
Ribonuclease P (RNaseP), a ribonucleoprotein, is an essential tRNA processing enzyme found in all living organisms. Since its discovery almost 40 years ago, research on RNase P has led to the discovery of the catalytic properties of RNA, and of the only known, naturally occurring RNA enzymes, RNase P catalytic RNA. The description of the catalytic properties of RNA has provided fundamental insight into the RNA world and these catalytic properties are being harnessed as therapeutic and prevention strategies for acquired and inherited diseases. Ribonuclease P is the first book to provide a comprehensive collection covering all aspects of current research on RNase P. The topics include kinetic and structural analysis, mechanism of catalysis, and its regulation and biogenesis in prokaryotes, eukaryotes, and organelles. Furthermore, research progresses on developing RNase P as a potential drug target for antimicrobial development and as a gene-targeting tool for anti-infective and anticancer therapy are also included. This book should be of general interests to molecular biologists and biochemists in both the academic section and pharmaceutical industry.
Content:
Front Matter....Pages i-xiv
History of RNase P and Overview of Its Catalytic Activity....Pages 1-15
The Evolution of RNase P and Its RNA....Pages 17-40
Over a Decade of Bacterial Ribonuclease P Modeling....Pages 41-62
Structural Studies of Ribonuclease P....Pages 63-78
Folding of Bacterial RNase P RNA....Pages 79-91
Kinetic Mechanism of Bacterial RNase P....Pages 93-111
Roles of Metal Ions in RNase P Catalysis....Pages 113-134
Challenges in RNase P Substrate Recognition: Considering the Biological Context....Pages 135-151
Archaeal RNase P: A Mosaic of Its Bacterial and Eukaryal Relatives....Pages 153-172
Eukaryote RNase P and RNase MRP....Pages 173-202
RNase P from Organelles....Pages 203-222
Human RNase P and Transcription....Pages 223-234
RNase P as a Drug Target....Pages 235-256
Ribonuclease P as a Tool....Pages 257-275
Back Matter....Pages 227-283
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