Ebook: Regulatory Networks in Stem Cells
- Tags: Cell Biology, Developmental Biology, Neurobiology
- Series: Stem Cell Biology and Regenerative Medicine
- Year: 2009
- Publisher: Humana Press
- Edition: 1
- Language: English
- pdf
This book ambitiously incorporates all the latest and essential subjects on molecular regulation in embryonic, tissue, and cancer stem cells. The chapter on pathology and therapy is also fairly informative.
I highly appreciate rigorous effort by all the editors and contributors, and strongly recommend this book to experts as well as students
- Dr. Shinya Yamanaka, Kyoto University, Japan
This new volume provides a broad overview of the regulation of stem cell renewal and differentiation from a diverse panel of expert authors. The chapters cover a remarkable range of topics, from molecular biology and model systems to translational and clinical implications of stem cell research. The book will be useful to both students and experienced researchers in the field.
- Dr. Martin Pera, University of Southern California, Los Angeles, CA. USA.
The application of stem cell 'thinking' and stem cell science to the biology of development, to tissue homeostasis, and to the generation of cancers has resulted in the explosion of new experiments and new models over the past several years. The rate of knowledge accumulation exceeds the abilities of most scientists, and especially aging scientists, to digest by reading the primary literature. Here Rajasekhar and Vemuri have brought together essays and reviews by world leaders in all areas of stem cell research--tissue and organ [adult] stem and progenitor cells, cancer stem cells, classical embryonic pluripotent stem cells, and pluripotent stem cells derived by nuclear reprogramming of adult somatic mature cell nuclei. It even covers the fast breaking field of induced pluripotent stem [iPS] cells, somatic cells that were reprogrammed by the transfection of as little as 3 genes whose gene products can re-set the genome of a mature cell to that of a pluripotent cell. The potentials of all of these areas to study and begin to understand human developmental biology, to produce from patients with genetic diseases pluripotent stem cells that can make all of the cell types affected in the disease, and the obvious translational attempts with tissue and organ stem cells promises to make these approaches, and the reviews in this book, the center of research in regenerative medicine. The identification of cancer stem cell in those cancers that have them [not cancers of stem cells, but the intratumoral cell subset that regenerates the entire tumor while self-renewing] will certainly help provide targets for drug therapies and novel imaging agents in the identified signal transduction pathways they use; and immunotherapy targets by the novel proteins and peptides [at least]that are created by mutations, translocations, and splicing anomalies central to the oncogenic progression in these cancer stem cells. The book is an essential addition to the libraries of scientists and institutions that do and teach stem cell research. I commend the editors and authors for an excellent and exciting book.
- Irv Weissman MD, Stanford University
This book ambitiously incorporates all the latest and essential subjects on molecular regulation in embryonic, tissue, and cancer stem cells. The chapter on pathology and therapy is also fairly informative.
I highly appreciate rigorous effort by all the editors and contributors, and strongly recommend this book to experts as well as students
- Dr. Shinya Yamanaka, Kyoto University, Japan
This new volume provides a broad overview of the regulation of stem cell renewal and differentiation from a diverse panel of expert authors. The chapters cover a remarkable range of topics, from molecular biology and model systems to translational and clinical implications of stem cell research. The book will be useful to both students and experienced researchers in the field.
- Dr. Martin Pera, University of Southern California, Los Angeles, CA. USA.
The application of stem cell 'thinking' and stem cell science to the biology of development, to tissue homeostasis, and to the generation of cancers has resulted in the explosion of new experiments and new models over the past several years. The rate of knowledge accumulation exceeds the abilities of most scientists, and especially aging scientists, to digest by reading the primary literature. Here Rajasekhar and Vemuri have brought together essays and reviews by world leaders in all areas of stem cell research--tissue and organ [adult] stem and progenitor cells, cancer stem cells, classical embryonic pluripotent stem cells, and pluripotent stem cells derived by nuclear reprogramming of adult somatic mature cell nuclei. It even covers the fast breaking field of induced pluripotent stem [iPS] cells, somatic cells that were reprogrammed by the transfection of as little as 3 genes whose gene products can re-set the genome of a mature cell to that of a pluripotent cell. The potentials of all of these areas to study and begin to understand human developmental biology, to produce from patients with genetic diseases pluripotent stem cells that can make all of the cell types affected in the disease, and the obvious translational attempts with tissue and organ stem cells promises to make these approaches, and the reviews in this book, the center of research in regenerative medicine. The identification of cancer stem cell in those cancers that have them [not cancers of stem cells, but the intratumoral cell subset that regenerates the entire tumor while self-renewing] will certainly help provide targets for drug therapies and novel imaging agents in the identified signal transduction pathways they use; and immunotherapy targets by the novel proteins and peptides [at least]that are created by mutations, translocations, and splicing anomalies central to the oncogenic progression in these cancer stem cells. The book is an essential addition to the libraries of scientists and institutions that do and teach stem cell research. I commend the editors and authors for an excellent and exciting book.
- Irv Weissman MD, Stanford University
This book ambitiously incorporates all the latest and essential subjects on molecular regulation in embryonic, tissue, and cancer stem cells. The chapter on pathology and therapy is also fairly informative.
I highly appreciate rigorous effort by all the editors and contributors, and strongly recommend this book to experts as well as students
- Dr. Shinya Yamanaka, Kyoto University, Japan
This new volume provides a broad overview of the regulation of stem cell renewal and differentiation from a diverse panel of expert authors. The chapters cover a remarkable range of topics, from molecular biology and model systems to translational and clinical implications of stem cell research. The book will be useful to both students and experienced researchers in the field.
- Dr. Martin Pera, University of Southern California, Los Angeles, CA. USA.
The application of stem cell 'thinking' and stem cell science to the biology of development, to tissue homeostasis, and to the generation of cancers has resulted in the explosion of new experiments and new models over the past several years. The rate of knowledge accumulation exceeds the abilities of most scientists, and especially aging scientists, to digest by reading the primary literature. Here Rajasekhar and Vemuri have brought together essays and reviews by world leaders in all areas of stem cell research--tissue and organ [adult] stem and progenitor cells, cancer stem cells, classical embryonic pluripotent stem cells, and pluripotent stem cells derived by nuclear reprogramming of adult somatic mature cell nuclei. It even covers the fast breaking field of induced pluripotent stem [iPS] cells, somatic cells that were reprogrammed by the transfection of as little as 3 genes whose gene products can re-set the genome of a mature cell to that of a pluripotent cell. The potentials of all of these areas to study and begin to understand human developmental biology, to produce from patients with genetic diseases pluripotent stem cells that can make all of the cell types affected in the disease, and the obvious translational attempts with tissue and organ stem cells promises to make these approaches, and the reviews in this book, the center of research in regenerative medicine. The identification of cancer stem cell in those cancers that have them [not cancers of stem cells, but the intratumoral cell subset that regenerates the entire tumor while self-renewing] will certainly help provide targets for drug therapies and novel imaging agents in the identified signal transduction pathways they use; and immunotherapy targets by the novel proteins and peptides [at least]that are created by mutations, translocations, and splicing anomalies central to the oncogenic progression in these cancer stem cells. The book is an essential addition to the libraries of scientists and institutions that do and teach stem cell research. I commend the editors and authors for an excellent and exciting book.
- Irv Weissman MD, Stanford University
Content:
Front Matter....Pages i-xxi
Front Matter....Pages 1-1
The Molecular Basis of Embryonic Stem Cell Self-Renewal....Pages 3-12
Asymmetric Behavior in Stem Cells....Pages 13-26
Determinants of Pluripotency in Mouse and Human Embryonic Stem Cells....Pages 27-36
Maintenance of Embryonic Stem Cell Pluripotency by Nanog-Mediated Dedifferentiation of Committed Mesoderm Progenitors....Pages 37-53
Human Embryonic Stem Cells and Germ Cell Development....Pages 55-66
Genomic Stability in Stem Cells....Pages 67-74
Genetic Manipulation of Human Embryonic Stem Cells....Pages 75-86
Transcriptional Networks Regulating Embryonic Stem Cell Fate Decisions....Pages 87-100
Use of Zebrafish to Dissect Gene Programs Regulating Hematopoietic Stem Cells....Pages 101-110
HOXB4 in Hematopoietic Stem Cell Regulation....Pages 111-122
Telomere and Telomerase for the Regulation of Stem Cells....Pages 123-134
The Role of Mitochondria in Stem Cell Biology....Pages 137-143
Front Matter....Pages 145-145
Extrinsic and Intrinsic Control of Germline Stem Cell Regulation in the Drosophila Ovary....Pages 147-154
The Niche Regulation of Hematopoietic Stem Cells....Pages 155-164
Environmental Signals Regulating Mesenchymal Progenitor Cell Growth and Differentiation....Pages 165-173
Microenvironmental Regulation of Adult Mesenchymal Stem Cells....Pages 175-184
Stem Cells, Hypoxia and Hypoxia-Inducible Factors....Pages 185-210
Front Matter....Pages 211-231
Stem Cell Epigenetics....Pages 233-233
Epigenetic Signature of Embryonal Stem Cells: A DNA Methylation Perspective....Pages 235-246
Front Matter....Pages 247-256
Epigenetic Basis for Differentiation Plasticity in Stem Cells....Pages 233-233
Role of DNA Methylation and Epigenetics in Stem Cells....Pages 257-268
DNA Methylation and the Epigenetic Program in Stem Cells....Pages 269-276
Polycomb Group Protein Homeostasis in Stem Cell Identity – A Hypothetical Appraisal....Pages 277-284
Front Matter....Pages 285-290
Signaling Pathways in Embryonic Stem Cells....Pages 291-291
Regulation of Stem Cell Systems by PI3K/Akt Signaling....Pages 293-308
Endothelial Ontogeny During Embryogenesis: Role of Cytokine Signaling Pathways....Pages 309-318
Signaling Networks in Mesenchymal Stem Cells....Pages 319-328
Single-Cell Approaches to Dissect Cellular Signaling Networks....Pages 329-335
Hematopoietic Stem Cells....Pages 337-345
Renal Stem Cells and Kidney Regeneration....Pages 347-377
The Endometrium: A Novel Source of Adult Stem/Progenitor Cells....Pages 379-390
Epithelial Stem Cells and the Development of the Thymus, Parathyroid, and Skin....Pages 391-404
Hepatic Stem Cells and Liver Development....Pages 405-437
Front Matter....Pages 439-469
The Idea and Evidence for the Tumor Stemness Switch....Pages 471-471
The Role of the Tumor Suppressor Fhit in Cancer-Initiating Cells....Pages 473-487
History of Cancer Stem Cells....Pages 489-493
Immune Responses to Stem Cells and Cancer Stem Cells....Pages 495-503
Leukemic Stem Cells: New Therapeutic Targets?....Pages 505-518
Solid Tumor Stem Cells – Implications for Cancer Therapy....Pages 519-526
Front Matter....Pages 527-543
Therapeutic Approaches to Target Cancer Stem Cells....Pages 471-471
Preclinical Evidence for Cellular Therapy as a Treatment for Neurological Disease....Pages 545-560
Improving Memory with Stem Cell Transplantation....Pages 561-573
Back Matter....Pages 575-583
....Pages 585-601