Ebook: Molecular Biology of Neuropsychiatric Disorders

It is generally accepted that neuropsychiatric disorders have a biological basis. Pathological changes leading to illness have been confirmed for Alzheimer’s (amyloid plaques) and Parkinson’s disease (loss of dopaminergic transmission) and are the foundation for studies on the molecular biology of these disorders. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research. Changes in a number of neuronal pathways and structures have been reported to be associated with these disorders and are currently under extensive investigation. The present volume reviews recent knowledge with emphasis on ongoing research findings. Current hypotheses based on these findings are described and discussed.

Knowing the molecular basis of these disorders is not only of academic interest, but is essential for:

• identifying risk factors contributing to the development of the disorders,

• detecting biomarkers which will aid in diagnosis,

• providing new and specific targets for development of causal pharmacological

treatment.

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It is generally accepted that neuropsychiatric disorders have a biological basis. Pathological changes leading to illness have been confirmed for Alzheimer’s (amyloid plaques) and Parkinson’s disease (loss of dopaminergic transmission) and are the foundation for studies on the molecular biology of these disorders. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research. Changes in a number of neuronal pathways and structures have been reported to be associated with these disorders and are currently under extensive investigation. The present volume reviews recent knowledge with emphasis on ongoing research findings. Current hypotheses based on these findings are described and discussed.

Knowing the molecular basis of these disorders is not only of academic interest, but is essential for:

• identifying risk factors contributing to the development of the disorders,

• detecting biomarkers which will aid in diagnosis,

• providing new and specific targets for development of causal pharmacological

treatment.

---

It is generally accepted that neuropsychiatric disorders have a biological basis. Pathological changes leading to illness have been confirmed for Alzheimer’s (amyloid plaques) and Parkinson’s disease (loss of dopaminergic transmission) and are the foundation for studies on the molecular biology of these disorders. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research. Changes in a number of neuronal pathways and structures have been reported to be associated with these disorders and are currently under extensive investigation. The present volume reviews recent knowledge with emphasis on ongoing research findings. Current hypotheses based on these findings are described and discussed.

Knowing the molecular basis of these disorders is not only of academic interest, but is essential for:

• identifying risk factors contributing to the development of the disorders,

• detecting biomarkers which will aid in diagnosis,

• providing new and specific targets for development of causal pharmacological

treatment.

Content:
Front Matter....Pages i-xiii
Decoding the Genetics and Underlying Mechanisms of Mood Disorders Sevilla D. Detera-Wadleigh and Takeo Yoshikawa....Pages 1-50
Dissecting the Molecular Causes of Schizophrenia....Pages 51-79
Autism Spectrum Disorders....Pages 81-98
Molecular Genetics of ADHD....Pages 99-164
The Genetics of Anxiety Disorders....Pages 165-185
Molecular Biology of Addiction and Substance Dependence....Pages 187-204
Neurobiology of Suicide....Pages 205-227
Molecular Genetics of Alzheimer's Disease....Pages 229-276
Molecular Biology of Parkinson's Disease....Pages 277-289
Back Matter....Pages 291-294

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It is generally accepted that neuropsychiatric disorders have a biological basis. Pathological changes leading to illness have been confirmed for Alzheimer’s (amyloid plaques) and Parkinson’s disease (loss of dopaminergic transmission) and are the foundation for studies on the molecular biology of these disorders. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research. Changes in a number of neuronal pathways and structures have been reported to be associated with these disorders and are currently under extensive investigation. The present volume reviews recent knowledge with emphasis on ongoing research findings. Current hypotheses based on these findings are described and discussed.

Knowing the molecular basis of these disorders is not only of academic interest, but is essential for:

• identifying risk factors contributing to the development of the disorders,

• detecting biomarkers which will aid in diagnosis,

• providing new and specific targets for development of causal pharmacological

treatment.

Content:
Front Matter....Pages i-xiii
Decoding the Genetics and Underlying Mechanisms of Mood Disorders Sevilla D. Detera-Wadleigh and Takeo Yoshikawa....Pages 1-50
Dissecting the Molecular Causes of Schizophrenia....Pages 51-79
Autism Spectrum Disorders....Pages 81-98
Molecular Genetics of ADHD....Pages 99-164
The Genetics of Anxiety Disorders....Pages 165-185
Molecular Biology of Addiction and Substance Dependence....Pages 187-204
Neurobiology of Suicide....Pages 205-227
Molecular Genetics of Alzheimer's Disease....Pages 229-276
Molecular Biology of Parkinson's Disease....Pages 277-289
Back Matter....Pages 291-294
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