Ebook: Cholera Toxins
- Tags: Medical Microbiology, Microbiology, Food Science, Biochemistry general, Cell Biology, Pharmacology/Toxicology
- Year: 2009
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
Vibrio cholerae, the causative organism of the disease Cholera, colonizes the small intestine and produces several different toxins among which the enterotoxin, or more widely known as cholera toxin (CT), happens to be the major virulence determinant that is responsible for the diarrheal syndrome. This book provides for the first time comprehensive and up-to-date information about all the toxins of Vibrio cholerae, their physical and chemical structures, their biosynthesis and its genetic regulation, their physiology, the molecular biology of their interactions with the host as well as their role in the development of an appropriate and effective cholera vaccine. It also offers relevant and necessary background information on the basic biology of the Vibrio cholerae cell and cholera bacteriophages.
Vibrio cholerae, the causative organism of the disease Cholera, colonizes the small intestine and produces several different toxins among which the enterotoxin, or more widely known as cholera toxin (CT), happens to be the major virulence determinant that is responsible for the diarrheal syndrome. This book provides for the first time comprehensive and up-to-date information about all the toxins of Vibrio cholerae, their physical and chemical structures, their biosynthesis and its genetic regulation, their physiology, the molecular biology of their interactions with the host as well as their role in the development of an appropriate and effective cholera vaccine. It also offers relevant and necessary background information on the basic biology of the Vibrio cholerae cell and cholera bacteriophages.
Vibrio cholerae, the causative organism of the disease Cholera, colonizes the small intestine and produces several different toxins among which the enterotoxin, or more widely known as cholera toxin (CT), happens to be the major virulence determinant that is responsible for the diarrheal syndrome. This book provides for the first time comprehensive and up-to-date information about all the toxins of Vibrio cholerae, their physical and chemical structures, their biosynthesis and its genetic regulation, their physiology, the molecular biology of their interactions with the host as well as their role in the development of an appropriate and effective cholera vaccine. It also offers relevant and necessary background information on the basic biology of the Vibrio cholerae cell and cholera bacteriophages.
Content:
Front Matter....Pages i-xiv
An Introduction to Cholera....Pages 1-3
Bacterial Toxins: A Brief Overview....Pages 5-11
Vibrio cholerae, the Causative Organism....Pages 13-31
Endotoxin of Vibrio cholerae: Physical and Chemical Characterization....Pages 33-54
Endotoxin of Vibrio cholerae: Genetics of Biosynthesis....Pages 55-79
Endotoxin of Vibrio cholerae: Biological Functions....Pages 81-103
Cholera Toxin (CT): Structure....Pages 105-123
Cholera Toxin (CT): Organization and Function of the Relevant Genetic Elements....Pages 125-145
Cholera Toxin (CT): Regulation of the Relevant Virulence Genes....Pages 147-164
Cholera Toxin (CT): Secretion by the Vibrios....Pages 165-184
Cholera Toxin (CT): Entry and Retrograde Trafficking into the Epithelial Cell....Pages 185-197
Cholera Toxin (CT): Immune Response of the Host and Vaccine Production....Pages 199-212
Other Toxins of Vibrio cholerae ....Pages 213-243
Concluding Notes....Pages 245-247
Back Matter....Pages 249-321
Vibrio cholerae, the causative organism of the disease Cholera, colonizes the small intestine and produces several different toxins among which the enterotoxin, or more widely known as cholera toxin (CT), happens to be the major virulence determinant that is responsible for the diarrheal syndrome. This book provides for the first time comprehensive and up-to-date information about all the toxins of Vibrio cholerae, their physical and chemical structures, their biosynthesis and its genetic regulation, their physiology, the molecular biology of their interactions with the host as well as their role in the development of an appropriate and effective cholera vaccine. It also offers relevant and necessary background information on the basic biology of the Vibrio cholerae cell and cholera bacteriophages.
Content:
Front Matter....Pages i-xiv
An Introduction to Cholera....Pages 1-3
Bacterial Toxins: A Brief Overview....Pages 5-11
Vibrio cholerae, the Causative Organism....Pages 13-31
Endotoxin of Vibrio cholerae: Physical and Chemical Characterization....Pages 33-54
Endotoxin of Vibrio cholerae: Genetics of Biosynthesis....Pages 55-79
Endotoxin of Vibrio cholerae: Biological Functions....Pages 81-103
Cholera Toxin (CT): Structure....Pages 105-123
Cholera Toxin (CT): Organization and Function of the Relevant Genetic Elements....Pages 125-145
Cholera Toxin (CT): Regulation of the Relevant Virulence Genes....Pages 147-164
Cholera Toxin (CT): Secretion by the Vibrios....Pages 165-184
Cholera Toxin (CT): Entry and Retrograde Trafficking into the Epithelial Cell....Pages 185-197
Cholera Toxin (CT): Immune Response of the Host and Vaccine Production....Pages 199-212
Other Toxins of Vibrio cholerae ....Pages 213-243
Concluding Notes....Pages 245-247
Back Matter....Pages 249-321
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