Ebook: DNA Tumor Viruses

The DNA tumor viruses are central to many branches of molecular and cellular biology. This very diverse group of viruses attack common cellular pathways, which makes them powerful tools for understanding how multiple complex pathways are integrated. Additionally, the unique mechanisms employed by each viral system to alter cellular functions serve as powerful molecular probes for the identification of new targets and pathways. The scientific impact of the DNA tumor viruses extends far beyond their etiologic role in human cancers, or their contributions to our basic understanding of the cellular pathways that drive tumorigenesis. Currently, research on these viruses lies at the interface of cancer and the innate and adaptive immune response, investigating how infectious agents influence, evade, and utilize systems that regulate these processes. Thus, DNA tumor viruses serve as models for the systems biology of host-pathogen interactions.

"DNA Tumor Viruses," edited by Blossom Damania and James M. Pipas, summarizes recent advances in our understanding of this diverse and fascinating collection of viruses.

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The DNA tumor viruses are central to many branches of molecular and cellular biology. This very diverse group of viruses attack common cellular pathways, which makes them powerful tools for understanding how multiple complex pathways are integrated. Additionally, the unique mechanisms employed by each viral system to alter cellular functions serve as powerful molecular probes for the identification of new targets and pathways. The scientific impact of the DNA tumor viruses extends far beyond their etiologic role in human cancers, or their contributions to our basic understanding of the cellular pathways that drive tumorigenesis. Currently, research on these viruses lies at the interface of cancer and the innate and adaptive immune response, investigating how infectious agents influence, evade, and utilize systems that regulate these processes. Thus, DNA tumor viruses serve as models for the systems biology of host-pathogen interactions.

"DNA Tumor Viruses," edited by Blossom Damania and James M. Pipas, summarizes recent advances in our understanding of this diverse and fascinating collection of viruses.

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The DNA tumor viruses are central to many branches of molecular and cellular biology. This very diverse group of viruses attack common cellular pathways, which makes them powerful tools for understanding how multiple complex pathways are integrated. Additionally, the unique mechanisms employed by each viral system to alter cellular functions serve as powerful molecular probes for the identification of new targets and pathways. The scientific impact of the DNA tumor viruses extends far beyond their etiologic role in human cancers, or their contributions to our basic understanding of the cellular pathways that drive tumorigenesis. Currently, research on these viruses lies at the interface of cancer and the innate and adaptive immune response, investigating how infectious agents influence, evade, and utilize systems that regulate these processes. Thus, DNA tumor viruses serve as models for the systems biology of host-pathogen interactions.

"DNA Tumor Viruses," edited by Blossom Damania and James M. Pipas, summarizes recent advances in our understanding of this diverse and fascinating collection of viruses.

Content:
Front Matter....Pages i-xxvi
Polyomavirus Life Cycle....Pages 1-24
Transformation by Polyomaviruses....Pages 25-52
Polyomaviruses and Disease....Pages 53-74
The Life Cycle of Human Papillomaviruses....Pages 75-104
Papillomavirus Transformation....Pages 105-126
Papillomaviruses: Biology, Diversity, and Pathogenesis....Pages 127-143
Adenovirus Transformation....Pages 145-162
Overview of the Large DNA Tumor Viruses....Pages 163-203
Epidemiology of EBV Infection....Pages 205-215
EBV Diseases....Pages 217-240
The Epstein–Barr Virus Genome....Pages 241-258
Epstein–Barr Virus Transforming Proteins: Biologic Properties and Contribution to Oncogenesis....Pages 259-284
The Epstein–Barr Virus Lytic Life Cycle....Pages 285-315
Epstein–Barr Virus Latent Infection Nuclear Proteins: Genome Maintenance and Regulation of Lymphocyte Cell Growth and Survival....Pages 317-353
Epstein–Barr Virus Entry....Pages 355-378
EBV Immunotherapy....Pages 379-401
KSHV Epidemiology and Subtype Evolution....Pages 403-439
Introduction to Diseases Associated with Kaposi’s Sarcoma-Associated Herpesvirus....Pages 441-468
Organization and Expression of the Kaposi’s Sarcoma-Associated Herpesvirus Genome....Pages 469-493
KSHV Latent Genes and Their Regulation....Pages 495-520
Regulation of Expression, Mode of Action and Downstream Targets of ORF50 Protein in KSHV Lytic Cycle Activation....Pages 521-553
HHV-8/KSHV Proteins Involved in Signaling and Transformation....Pages 555-582
KSHV Entry and Infection of Target Cells....Pages 583-609
KSHV Immune Evasion....Pages 611-644
Non-coding Regulatory RNAs of the DNA Tumor Viruses....Pages 645-682
AIDS and Associated Malignancies....Pages 683-702
Primate Models for Gammaherpesvirus-Associated Malignancies....Pages 703-733
Murine Gammaherpesvirus 68 Infection of Mice: A Small Animal Model for Characterizing Basic Aspects of Gammaherpesvirus Pathogenesis....Pages 735-775
Back Matter....Pages 777-794

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The DNA tumor viruses are central to many branches of molecular and cellular biology. This very diverse group of viruses attack common cellular pathways, which makes them powerful tools for understanding how multiple complex pathways are integrated. Additionally, the unique mechanisms employed by each viral system to alter cellular functions serve as powerful molecular probes for the identification of new targets and pathways. The scientific impact of the DNA tumor viruses extends far beyond their etiologic role in human cancers, or their contributions to our basic understanding of the cellular pathways that drive tumorigenesis. Currently, research on these viruses lies at the interface of cancer and the innate and adaptive immune response, investigating how infectious agents influence, evade, and utilize systems that regulate these processes. Thus, DNA tumor viruses serve as models for the systems biology of host-pathogen interactions.

"DNA Tumor Viruses," edited by Blossom Damania and James M. Pipas, summarizes recent advances in our understanding of this diverse and fascinating collection of viruses.

Content:
Front Matter....Pages i-xxvi
Polyomavirus Life Cycle....Pages 1-24
Transformation by Polyomaviruses....Pages 25-52
Polyomaviruses and Disease....Pages 53-74
The Life Cycle of Human Papillomaviruses....Pages 75-104
Papillomavirus Transformation....Pages 105-126
Papillomaviruses: Biology, Diversity, and Pathogenesis....Pages 127-143
Adenovirus Transformation....Pages 145-162
Overview of the Large DNA Tumor Viruses....Pages 163-203
Epidemiology of EBV Infection....Pages 205-215
EBV Diseases....Pages 217-240
The Epstein–Barr Virus Genome....Pages 241-258
Epstein–Barr Virus Transforming Proteins: Biologic Properties and Contribution to Oncogenesis....Pages 259-284
The Epstein–Barr Virus Lytic Life Cycle....Pages 285-315
Epstein–Barr Virus Latent Infection Nuclear Proteins: Genome Maintenance and Regulation of Lymphocyte Cell Growth and Survival....Pages 317-353
Epstein–Barr Virus Entry....Pages 355-378
EBV Immunotherapy....Pages 379-401
KSHV Epidemiology and Subtype Evolution....Pages 403-439
Introduction to Diseases Associated with Kaposi’s Sarcoma-Associated Herpesvirus....Pages 441-468
Organization and Expression of the Kaposi’s Sarcoma-Associated Herpesvirus Genome....Pages 469-493
KSHV Latent Genes and Their Regulation....Pages 495-520
Regulation of Expression, Mode of Action and Downstream Targets of ORF50 Protein in KSHV Lytic Cycle Activation....Pages 521-553
HHV-8/KSHV Proteins Involved in Signaling and Transformation....Pages 555-582
KSHV Entry and Infection of Target Cells....Pages 583-609
KSHV Immune Evasion....Pages 611-644
Non-coding Regulatory RNAs of the DNA Tumor Viruses....Pages 645-682
AIDS and Associated Malignancies....Pages 683-702
Primate Models for Gammaherpesvirus-Associated Malignancies....Pages 703-733
Murine Gammaherpesvirus 68 Infection of Mice: A Small Animal Model for Characterizing Basic Aspects of Gammaherpesvirus Pathogenesis....Pages 735-775
Back Matter....Pages 777-794
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