Ebook: The Biology of Kruppel-like Factors
Author: Ryozo Nagai Ichiro Manabe Toru Suzuki (auth.) Ryozo Nagai Scott L. Friedman Masato Kasuga (eds.)
- Tags: Cell Biology, Animal Genetics and Genomics, Animal Physiology, Cancer Research, Developmental Biology, Molecular Medicine
- Year: 2009
- Publisher: Springer Japan
- Edition: 1
- Language: English
- pdf
Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise treatise written to date by leading experts in the field, it serves as an authoritative review of this family of molecules and is an essential reference for all who are interested in KLFs. The book also explores the potential of KLFs as targets for novel therapeutics and diagnostics, and will be invaluable in those fields.
Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise treatise written to date by leading experts in the field, it serves as an authoritative review of this family of molecules and is an essential reference for all who are interested in KLFs. The book also explores the potential of KLFs as targets for novel therapeutics and diagnostics, and will be invaluable in those fields.
Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise treatise written to date by leading experts in the field, it serves as an authoritative review of this family of molecules and is an essential reference for all who are interested in KLFs. The book also explores the potential of KLFs as targets for novel therapeutics and diagnostics, and will be invaluable in those fields.
Content:
Front Matter....Pages i-viii
Kruppel-like Factors: Ingenious Three Fingers Directing Biology and Pathobiology....Pages 3-18
Molecular Structures of Kruppel-like Factors....Pages 21-31
Kruppel-like Factor Proteins and Chromatin Dynamics....Pages 33-49
Co-regulator Interactions in Kruppel-like Factor Transcriptional Programs....Pages 51-64
Developmental Expression of Kruppel-like Factors....Pages 67-82
Expanded Role for EKLF/KLF1 Within the Hematopoietic Lineage....Pages 83-93
Roles of Kruppel-like Factors in Lymphocytes....Pages 95-106
Kruppel-like Factors in Gastrointestinal Tract Development and Differentiation....Pages 107-119
Gene Interactions Between Kruppel-like Factors in Development....Pages 121-130
Kruppel-like Factors in Stem Cell Biology....Pages 131-138
Kruppel-like Factors and the Liver....Pages 141-150
Role of Kruppel-like Factor 15 in Adipocytes....Pages 151-157
Kruppel-like Factors in the Heart....Pages 159-171
Kruppel-like Factors in the Vascular Endothelium....Pages 173-184
Kruppel-like Factors KLF2, KLF4, and KLF5: Central Regulators of Smooth Muscle Function....Pages 185-204
Kruppel-like Factors in Cancers....Pages 205-219
Kruppel-like Factors KLF6 and KLF6-SV1 in the Diagnosis and Treatment of Cancer....Pages 223-244
Drug Development and Kruppel-like Factors....Pages 245-252
Back Matter....Pages 253-258
Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise treatise written to date by leading experts in the field, it serves as an authoritative review of this family of molecules and is an essential reference for all who are interested in KLFs. The book also explores the potential of KLFs as targets for novel therapeutics and diagnostics, and will be invaluable in those fields.
Content:
Front Matter....Pages i-viii
Kruppel-like Factors: Ingenious Three Fingers Directing Biology and Pathobiology....Pages 3-18
Molecular Structures of Kruppel-like Factors....Pages 21-31
Kruppel-like Factor Proteins and Chromatin Dynamics....Pages 33-49
Co-regulator Interactions in Kruppel-like Factor Transcriptional Programs....Pages 51-64
Developmental Expression of Kruppel-like Factors....Pages 67-82
Expanded Role for EKLF/KLF1 Within the Hematopoietic Lineage....Pages 83-93
Roles of Kruppel-like Factors in Lymphocytes....Pages 95-106
Kruppel-like Factors in Gastrointestinal Tract Development and Differentiation....Pages 107-119
Gene Interactions Between Kruppel-like Factors in Development....Pages 121-130
Kruppel-like Factors in Stem Cell Biology....Pages 131-138
Kruppel-like Factors and the Liver....Pages 141-150
Role of Kruppel-like Factor 15 in Adipocytes....Pages 151-157
Kruppel-like Factors in the Heart....Pages 159-171
Kruppel-like Factors in the Vascular Endothelium....Pages 173-184
Kruppel-like Factors KLF2, KLF4, and KLF5: Central Regulators of Smooth Muscle Function....Pages 185-204
Kruppel-like Factors in Cancers....Pages 205-219
Kruppel-like Factors KLF6 and KLF6-SV1 in the Diagnosis and Treatment of Cancer....Pages 223-244
Drug Development and Kruppel-like Factors....Pages 245-252
Back Matter....Pages 253-258
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