Ebook: VEGF in Development
Author: Christiana Ruhrberg PhD (auth.)
- Tags: Biochemistry general
- Series: Molecular Biology Intelligence Unit
- Year: 2008
- Publisher: Springer-Verlag New York
- Edition: 1
- Language: English
- pdf
This book is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a functional blood vessel circuit. In addition, VEGFA is emerging as a versatile patterning factor for several non-endothelial cell types in vertebrates. Thus, it plays a central role during organ development at multiple levels, including blood vessel growth, vessel-mediated organ induction and tissue differentiation.
This book is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a functional blood vessel circuit. In addition, VEGFA is emerging as a versatile patterning factor for several non-endothelial cell types in vertebrates. Thus, it plays a central role during organ development at multiple levels, including blood vessel growth, vessel-mediated organ induction and tissue differentiation.
Content:
Front Matter....Pages i-xi
The Biology of Vascular Endothelial Cell Growth Factor Isoforms....Pages 1-13
VEGF Receptor Signalling in Vertebrate Development....Pages 14-29
VEGF Gene Regulation....Pages 30-39
Embryonic Vasculogenesis and Hematopoietic Specification....Pages 40-51
Role of VEGF in Organogenesis....Pages 52-67
VEGF and Endothelial Guidance in Angiogenic Sprouting....Pages 68-78
Vascular and Nonvascular Roles of VEGF in Bone Development....Pages 79-90
VEGF in the Nervous System....Pages 91-103
Back Matter....Pages 105-106
This book is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a functional blood vessel circuit. In addition, VEGFA is emerging as a versatile patterning factor for several non-endothelial cell types in vertebrates. Thus, it plays a central role during organ development at multiple levels, including blood vessel growth, vessel-mediated organ induction and tissue differentiation.
Content:
Front Matter....Pages i-xi
The Biology of Vascular Endothelial Cell Growth Factor Isoforms....Pages 1-13
VEGF Receptor Signalling in Vertebrate Development....Pages 14-29
VEGF Gene Regulation....Pages 30-39
Embryonic Vasculogenesis and Hematopoietic Specification....Pages 40-51
Role of VEGF in Organogenesis....Pages 52-67
VEGF and Endothelial Guidance in Angiogenic Sprouting....Pages 68-78
Vascular and Nonvascular Roles of VEGF in Bone Development....Pages 79-90
VEGF in the Nervous System....Pages 91-103
Back Matter....Pages 105-106
....