Ebook: Organocatalysis
- Tags: Organic Chemistry, Medicinal Chemistry, Biochemistry general
- Series: Ernst Schering Foundation Symposium Proceedings 2007/2
- Year: 2008
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
Due to the emergence of organocatalysis as a highly active and very exciting field of research both in academia and the life sciences industry, an Ernst Schering Research Foundation Symposium was organized in 2007 to bring together the scientific leaders in this field and to discuss the basics and current progress of organocatalysis and its application in drug discovery. Various aspects of organocatalysis are addressed in this volume, covering a broad range of synthetic transformations such as functional group interconversions as well as CC- and CX-bond formations and their applications in natural product and drug syntheses. In addition, the design and scope of various catalyst systems are discussed, from small molecules, to peptides, to genetically engineered enzymes.
Due to the emergence of organocatalysis as a highly active and very exciting field of research both in academia and the life sciences industry, an Ernst Schering Research Foundation Symposium was organized in 2007 to bring together the scientific leaders in this field and to discuss the basics and current progress of organocatalysis and its application in drug discovery. Various aspects of organocatalysis are addressed in this volume, covering a broad range of synthetic transformations such as functional group interconversions as well as CC- and CX-bond formations and their applications in natural product and drug syntheses. In addition, the design and scope of various catalyst systems are discussed, from small molecules, to peptides, to genetically engineered enzymes.
Due to the emergence of organocatalysis as a highly active and very exciting field of research both in academia and the life sciences industry, an Ernst Schering Research Foundation Symposium was organized in 2007 to bring together the scientific leaders in this field and to discuss the basics and current progress of organocatalysis and its application in drug discovery. Various aspects of organocatalysis are addressed in this volume, covering a broad range of synthetic transformations such as functional group interconversions as well as CC- and CX-bond formations and their applications in natural product and drug syntheses. In addition, the design and scope of various catalyst systems are discussed, from small molecules, to peptides, to genetically engineered enzymes.
Content:
Front Matter....Pages i-xiv
Chiral Organocatalysts for Enantioselective Photochemical Reactions....Pages 1-50
Organocatalytic Syntheses of Bioactive Natural Products....Pages 51-75
Recoverable, Soluble Polymer-Supported Organic Catalysts....Pages 76-96
Controlling the Selectivity and Stability of Proteins by New Strategies in Directed Evolution: The Case of Organocatalytic Enzymes....Pages 98-140
Biomimetic Organocatalytic C–C-Bond Formations....Pages 145-157
N-Heterocyclic Carbenes: Organocatalysts Displaying Diverse Modes of Action....Pages 158-180
Organocatalysis by Hydrogen Bonding Networks....Pages 181-202
Nucleophilic Carbenes as Organocatalysts....Pages 203-225
Asymmetric Organocatalysis on a Technical Scale: Current Status and Future Challenges....Pages 227-258
New Concepts for Organocatalysis....Pages 259-300
New Developments in Enantioselective Bronsted Acid Catalysis: Chiral Ion Pair Catalysis and Beyond....Pages 301-350
Due to the emergence of organocatalysis as a highly active and very exciting field of research both in academia and the life sciences industry, an Ernst Schering Research Foundation Symposium was organized in 2007 to bring together the scientific leaders in this field and to discuss the basics and current progress of organocatalysis and its application in drug discovery. Various aspects of organocatalysis are addressed in this volume, covering a broad range of synthetic transformations such as functional group interconversions as well as CC- and CX-bond formations and their applications in natural product and drug syntheses. In addition, the design and scope of various catalyst systems are discussed, from small molecules, to peptides, to genetically engineered enzymes.
Content:
Front Matter....Pages i-xiv
Chiral Organocatalysts for Enantioselective Photochemical Reactions....Pages 1-50
Organocatalytic Syntheses of Bioactive Natural Products....Pages 51-75
Recoverable, Soluble Polymer-Supported Organic Catalysts....Pages 76-96
Controlling the Selectivity and Stability of Proteins by New Strategies in Directed Evolution: The Case of Organocatalytic Enzymes....Pages 98-140
Biomimetic Organocatalytic C–C-Bond Formations....Pages 145-157
N-Heterocyclic Carbenes: Organocatalysts Displaying Diverse Modes of Action....Pages 158-180
Organocatalysis by Hydrogen Bonding Networks....Pages 181-202
Nucleophilic Carbenes as Organocatalysts....Pages 203-225
Asymmetric Organocatalysis on a Technical Scale: Current Status and Future Challenges....Pages 227-258
New Concepts for Organocatalysis....Pages 259-300
New Developments in Enantioselective Bronsted Acid Catalysis: Chiral Ion Pair Catalysis and Beyond....Pages 301-350
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