Ebook: Introduction to Systems Biology
- Tags: Pharmacology/Toxicology, Cell Biology, Biochemistry general, Biological Microscopy, Developmental Biology
- Year: 2007
- Publisher: Humana Press
- Edition: 1
- Language: English
- pdf
Introduction to Systems Biology is an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors provide a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches to help understand biological dynamic systems. The final sections of the volume provide ideas for theoretical and modeling optimization in systemic biological researches, presenting most algorithms as implementations, including an up-to-date full range of bioinformatic programs and available successful applications.
Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. Introduction to Systems Biology is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.
This book provides an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors offer a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches to help understand biological dynamic systems. The final sections of the volume provide ideas for theoretical and modeling optimization in systemic biological researches, presenting most algorithms as implementations, including an up-to-date full range of bioinformatic programs and available successful applications.
Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. The book is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.
This book provides an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors offer a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches to help understand biological dynamic systems. The final sections of the volume provide ideas for theoretical and modeling optimization in systemic biological researches, presenting most algorithms as implementations, including an up-to-date full range of bioinformatic programs and available successful applications.
Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. The book is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.
Content:
Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Scientific Challenges in Systems Biology....Pages 3-13
Bringing Genomes to Life: The Use of Genome-Scale In Silico Models....Pages 14-36
From Gene Expression to Metabolic Fluxes....Pages 37-66
Front Matter....Pages 67-67
Handling and Interpreting Gene Groups....Pages 69-84
The Dynamic Transcriptome of Mice....Pages 85-105
Dissecting Transcriptional Control Networks....Pages 106-123
Reconstruction and Structural Analysis of Metabolic and Regulatory Networks....Pages 124-146
Cross-Species Comparison Using Expression Data....Pages 147-159
Methods for Protein-Protein Interaction Analysis....Pages 160-182
Genome-Scale Assessment of Phenotypic Changes During Adaptive Evolution....Pages 183-195
Location Proteomics....Pages 196-214
Front Matter....Pages 215-215
Reconstructing Transcriptional Networks Using Gene Expression Profiling and Bayesian State-Space Models....Pages 217-241
Modeling Spatiotemporal Dynamics of Multicellular Signaling....Pages 242-260
Kinetics of Dimension-Restricted Conditions....Pages 261-281
Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction....Pages 282-299
Employing Systems Biology to Quantify Receptor Tyrosine Kinase Signaling in Time and Space....Pages 300-318
Dynamic Instabilities Within Living Neutrophils....Pages 319-335
Efficiency, Robustness, and Stochasticity of Gene Regulatory Networks in Systems Biology: ? Switch as a Working Example....Pages 336-371
Applications, Representation, and Management of Signaling Pathway Information: Introduction to the SigPath Project....Pages 372-392
Front Matter....Pages 393-393
SBML Models and MathSBML....Pages 395-421
Front Matter....Pages 393-393
CellDesigner: A Graphical Biological Network Editor and Workbench Interfacing Simulator....Pages 422-434
DBRF-MEGN Method: An Algorithm for Inferring Gene Regulatory Networks from Large-Scale Gene Expression Profiles....Pages 435-448
Systematic Determination of Biological Network Topology: Nonintegral Connectivity Method (NICM)....Pages 449-471
Storing, Searching, and Disseminating Experimental Proteomics Data....Pages 472-483
Representing and Analyzing Biochemical Networks Using BioMaze....Pages 484-507
Back Matter....Pages 509-542
This book provides an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors offer a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches to help understand biological dynamic systems. The final sections of the volume provide ideas for theoretical and modeling optimization in systemic biological researches, presenting most algorithms as implementations, including an up-to-date full range of bioinformatic programs and available successful applications.
Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. The book is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.
Content:
Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Scientific Challenges in Systems Biology....Pages 3-13
Bringing Genomes to Life: The Use of Genome-Scale In Silico Models....Pages 14-36
From Gene Expression to Metabolic Fluxes....Pages 37-66
Front Matter....Pages 67-67
Handling and Interpreting Gene Groups....Pages 69-84
The Dynamic Transcriptome of Mice....Pages 85-105
Dissecting Transcriptional Control Networks....Pages 106-123
Reconstruction and Structural Analysis of Metabolic and Regulatory Networks....Pages 124-146
Cross-Species Comparison Using Expression Data....Pages 147-159
Methods for Protein-Protein Interaction Analysis....Pages 160-182
Genome-Scale Assessment of Phenotypic Changes During Adaptive Evolution....Pages 183-195
Location Proteomics....Pages 196-214
Front Matter....Pages 215-215
Reconstructing Transcriptional Networks Using Gene Expression Profiling and Bayesian State-Space Models....Pages 217-241
Modeling Spatiotemporal Dynamics of Multicellular Signaling....Pages 242-260
Kinetics of Dimension-Restricted Conditions....Pages 261-281
Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction....Pages 282-299
Employing Systems Biology to Quantify Receptor Tyrosine Kinase Signaling in Time and Space....Pages 300-318
Dynamic Instabilities Within Living Neutrophils....Pages 319-335
Efficiency, Robustness, and Stochasticity of Gene Regulatory Networks in Systems Biology: ? Switch as a Working Example....Pages 336-371
Applications, Representation, and Management of Signaling Pathway Information: Introduction to the SigPath Project....Pages 372-392
Front Matter....Pages 393-393
SBML Models and MathSBML....Pages 395-421
Front Matter....Pages 393-393
CellDesigner: A Graphical Biological Network Editor and Workbench Interfacing Simulator....Pages 422-434
DBRF-MEGN Method: An Algorithm for Inferring Gene Regulatory Networks from Large-Scale Gene Expression Profiles....Pages 435-448
Systematic Determination of Biological Network Topology: Nonintegral Connectivity Method (NICM)....Pages 449-471
Storing, Searching, and Disseminating Experimental Proteomics Data....Pages 472-483
Representing and Analyzing Biochemical Networks Using BioMaze....Pages 484-507
Back Matter....Pages 509-542
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