Ebook: Oxidative Damage to Nucleic Acids

This book provides an up-to-date coverage of selected topics in the area of nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics. In addition to some of the traditionally covered topics, we have included some areas that receive less attention in similar volumes, for example chapters focusing on damage to nucleic acids by halogenating and nitrating species, gene-specific damage, telomere shortening and damage to promoter regions. Through this approach, we recognize additionally the importance of nucleic acid damage beyond mutation and in pathological conditions other than carcinogenesis. The primary audience for the book would be research scientists and advanced postgraduate students, the book may also be of interest to clinicians with strong research interests. We would expect readers to come away from this book with a greater appreciation of the topic, particularly appraising the reader of areas that may not necessarily have been covered in such a volume before.

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This book provides up-to-date coverage of selected topics in nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics. In addition to some of the traditionally covered topics, the book covers areas that receive less attention in similar volumes, for example chapters focusing on damage to nucleic acids by halogenating and nitrating species, gene-specific damage, telomere shortening and damage to promoter regions. Through this approach, coverage recognizes the importance of nucleic acid damage beyond mutation and in pathological conditions other than carcinogenesis. This book will appeal to research scientists and advanced postgraduate students and may also be of interest to clinicians with strong research interests.

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This book provides up-to-date coverage of selected topics in nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics. In addition to some of the traditionally covered topics, the book covers areas that receive less attention in similar volumes, for example chapters focusing on damage to nucleic acids by halogenating and nitrating species, gene-specific damage, telomere shortening and damage to promoter regions. Through this approach, coverage recognizes the importance of nucleic acid damage beyond mutation and in pathological conditions other than carcinogenesis. This book will appeal to research scientists and advanced postgraduate students and may also be of interest to clinicians with strong research interests.

Content:
Front Matter....Pages i-xvii
Oxidatively Generated Damage to Cellular DNA: Mechanistic Aspects....Pages 1-13
Chlorination and Nitration of DNA and Nucleic Acid Components....Pages 14-39
Prevention of the Mutagenicity and Cytotoxicity of Oxidized Purine Nucleotides....Pages 40-53
Nucleotide Incision Repair: An Alternative and Ubiquitous Pathway to Handle Oxidative DNA Damage....Pages 54-66
OGG1: From Structural Analysis to the Knockout Mouse....Pages 67-80
Processing of 3?-End Modified DNA Strand Breaks Induced by Oxidative Damage....Pages 81-90
Oxidative Damage and Promoter Function....Pages 91-99
Oxidative DNA Damage and Telomere Shortening....Pages 100-108
Oxidative Damage and Repair in the Mitochondrial Genome....Pages 109-122
The Role of Oxidative Damage to Nucleic Acids in the Pathogenesis of Neurological Disease....Pages 123-140
Nucleic Acid Oxidation and the Pathogenesis of Cardiovascular Diseases....Pages 141-152
Oxidative DNA Damage and Carcinogenesis....Pages 153-166
The Physiological and Pathological Roles of Oxidative Damage to DNA in Relation to Life Stage....Pages 167-177
Analysis of 8-Hydroxy-2?-Deoxyguanosine as a Marker of Oxidatively Damaged DNA in Relation to Carcinogenesis and Aging....Pages 178-187
Oxidatively Damaged DNA and Inflammation....Pages 188-206
The Role of Antioxidants in the Prevention of Oxidative Damage to Nucleic Acids....Pages 207-223
Back Matter....Pages 225-228

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This book provides up-to-date coverage of selected topics in nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics. In addition to some of the traditionally covered topics, the book covers areas that receive less attention in similar volumes, for example chapters focusing on damage to nucleic acids by halogenating and nitrating species, gene-specific damage, telomere shortening and damage to promoter regions. Through this approach, coverage recognizes the importance of nucleic acid damage beyond mutation and in pathological conditions other than carcinogenesis. This book will appeal to research scientists and advanced postgraduate students and may also be of interest to clinicians with strong research interests.

Content:
Front Matter....Pages i-xvii
Oxidatively Generated Damage to Cellular DNA: Mechanistic Aspects....Pages 1-13
Chlorination and Nitration of DNA and Nucleic Acid Components....Pages 14-39
Prevention of the Mutagenicity and Cytotoxicity of Oxidized Purine Nucleotides....Pages 40-53
Nucleotide Incision Repair: An Alternative and Ubiquitous Pathway to Handle Oxidative DNA Damage....Pages 54-66
OGG1: From Structural Analysis to the Knockout Mouse....Pages 67-80
Processing of 3?-End Modified DNA Strand Breaks Induced by Oxidative Damage....Pages 81-90
Oxidative Damage and Promoter Function....Pages 91-99
Oxidative DNA Damage and Telomere Shortening....Pages 100-108
Oxidative Damage and Repair in the Mitochondrial Genome....Pages 109-122
The Role of Oxidative Damage to Nucleic Acids in the Pathogenesis of Neurological Disease....Pages 123-140
Nucleic Acid Oxidation and the Pathogenesis of Cardiovascular Diseases....Pages 141-152
Oxidative DNA Damage and Carcinogenesis....Pages 153-166
The Physiological and Pathological Roles of Oxidative Damage to DNA in Relation to Life Stage....Pages 167-177
Analysis of 8-Hydroxy-2?-Deoxyguanosine as a Marker of Oxidatively Damaged DNA in Relation to Carcinogenesis and Aging....Pages 178-187
Oxidatively Damaged DNA and Inflammation....Pages 188-206
The Role of Antioxidants in the Prevention of Oxidative Damage to Nucleic Acids....Pages 207-223
Back Matter....Pages 225-228
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