Ebook: Shh and Gli Signalling and Development
- Tags: Developmental Biology, Cell Biology, Human Physiology
- Series: Molecular Biology Intelligence Unit
- Year: 2007
- Publisher: Springer-Verlag New York
- Edition: 1
- Language: English
- pdf
he hedgehog signalling pathway is highly conserved and seen in organisms ranging from Drosophila to humans. This pathway is Tcritical in determining cell fate decisions in a variety of different cell types. There are several vertebrate analogues of the Drosophila hedgehog protein of which the most widely studied is Sonic hedgehog (Shh). Shh signalling classically involves the Gli family of zinc-fmger transcription factors. The Shh signalling pathway is well characterised in the develop ment of a number of vertebrate organ systems. It could indeed be argued that the Shh and Gli signalling may well be involved at some stage in the development of all the major organ systems in vertebrates. This volume rep resents a concerted drive to bring together *state of the art' reviews by lead ing experts in the field of Shh and Gli signalling in development from all over the world. The chapters span vertebrate organisms from zebrafish to humans and cover development of the multiple organ systems in which the Shh signalling pathway is crucial for normal development. There are chap ters on the development of the central nervous system, skeletal struc tures, visceral organs, prostate, lung, immune system and the structures of the human face. The authors themselves span three major continents and multiple nationalities which admirably illustrates the worldwide nature of the science.
This book reviews and summarizes the current state of understanding of the Sonic Hedgehog (Shh) pathway and the downstream Gli transcription factors during development. An introductory chapter reviews the pathway both in invertebrates and vertebrates. Subsequent chapters deal with the role of Shh during the development of specific organs and body systems in a variety of organisms including zebrafish, mouse and human.
The book can be read in its entirety to provide readers with a comprehensive review of the importance of this signalling pathway for normal development and insights into ongoing research in this field. Such an approach may be useful for undergraduates or post-graduate students with an interest in development, cell signalling cascades or those specifically researching some aspect of Shh.
This book reviews and summarizes the current state of understanding of the Sonic Hedgehog (Shh) pathway and the downstream Gli transcription factors during development. An introductory chapter reviews the pathway both in invertebrates and vertebrates. Subsequent chapters deal with the role of Shh during the development of specific organs and body systems in a variety of organisms including zebrafish, mouse and human.
The book can be read in its entirety to provide readers with a comprehensive review of the importance of this signalling pathway for normal development and insights into ongoing research in this field. Such an approach may be useful for undergraduates or post-graduate students with an interest in development, cell signalling cascades or those specifically researching some aspect of Shh.
Content:
Front Matter....Pages i-x
Introduction....Pages 1-11
Sonic Hedgehog Signalling in Dorsal Midline and Neural Development....Pages 12-22
Role of Hedgehog and Gli Signalling in Telencephalic Development....Pages 23-35
Role of Shh and Gli Signalling in Oligodendroglial Development....Pages 36-43
The Role of Sonic Hedgehog Signalling in Craniofacial Development....Pages 44-57
Multiple Roles for Hedgehog Signalling in Zebrafish Eye Development....Pages 58-68
Sonic Hedgehog Signalling during Tooth Morphogenesis....Pages 69-78
Limb Pattern Formation....Pages 79-92
Sonic Hedgehog Signalling in the Developing and Regenerating Fins of Zebrafish....Pages 93-106
Hedgehog Signalling in T Lymphocyte Development....Pages 107-115
Hedgehog Signalling in Prostate Morphogenesis....Pages 116-124
Sonic Hedgehog Signalling in Visceral Organ Development....Pages 125-136
Shh/Gli Signalling during Murine Lung Development....Pages 137-146
New Perspectives in Shh Signalling?....Pages 147-154
Back Matter....Pages 155-158
This book reviews and summarizes the current state of understanding of the Sonic Hedgehog (Shh) pathway and the downstream Gli transcription factors during development. An introductory chapter reviews the pathway both in invertebrates and vertebrates. Subsequent chapters deal with the role of Shh during the development of specific organs and body systems in a variety of organisms including zebrafish, mouse and human.
The book can be read in its entirety to provide readers with a comprehensive review of the importance of this signalling pathway for normal development and insights into ongoing research in this field. Such an approach may be useful for undergraduates or post-graduate students with an interest in development, cell signalling cascades or those specifically researching some aspect of Shh.
Content:
Front Matter....Pages i-x
Introduction....Pages 1-11
Sonic Hedgehog Signalling in Dorsal Midline and Neural Development....Pages 12-22
Role of Hedgehog and Gli Signalling in Telencephalic Development....Pages 23-35
Role of Shh and Gli Signalling in Oligodendroglial Development....Pages 36-43
The Role of Sonic Hedgehog Signalling in Craniofacial Development....Pages 44-57
Multiple Roles for Hedgehog Signalling in Zebrafish Eye Development....Pages 58-68
Sonic Hedgehog Signalling during Tooth Morphogenesis....Pages 69-78
Limb Pattern Formation....Pages 79-92
Sonic Hedgehog Signalling in the Developing and Regenerating Fins of Zebrafish....Pages 93-106
Hedgehog Signalling in T Lymphocyte Development....Pages 107-115
Hedgehog Signalling in Prostate Morphogenesis....Pages 116-124
Sonic Hedgehog Signalling in Visceral Organ Development....Pages 125-136
Shh/Gli Signalling during Murine Lung Development....Pages 137-146
New Perspectives in Shh Signalling?....Pages 147-154
Back Matter....Pages 155-158
....