Ebook: GtBP Family Proteins
Author: G. Chinnadurai (auth.)
- Tags: Medical Microbiology, Cell Biology
- Series: Molecular Biology Intelligence Unit
- Year: 2007
- Publisher: Springer-Verlag New York
- Edition: 1
- Language: English
- pdf
This book is a comprehensive monograph on the CtBP family proteins. These proteins are gaining wide scientific interest due to their critical roles in animal development and in oncogenesis. The CtBP family proteins are multifunctional. They predominantly function as transcriptional corepressors in the nucleus by recruiting various histone modifying enzymes such as histone deacetylases, histone methylases and a histone demethylase. They also perform several diverse cytosolic functions such as Golgi maintenance and in central nervous system synapses.
This book is a comprehensive monograph on the CtBP family proteins. These proteins are gaining wide scientific interest due to their critical roles in animal development and in oncogenesis. The CtBP family proteins are multifunctional. They predominantly function as transcriptional corepressors in the nucleus by recruiting various histone modifying enzymes such as histone deacetylases, histone methylases and a histone demethylase. They also perform several diverse cytosolic functions such as Golgi maintenance and in central nervous system synapses.
Content:
Front Matter....Pages i-ix
CtBP Family Proteins....Pages 1-17
Transcriptional Repression by the CtBP Corepressor in Drosophila ....Pages 18-27
CtBP and Hematopoietic Transcriptional Regulators....Pages 28-38
CtBP....Pages 39-43
The Significance of the CtBP — AdE1A Interaction during Viral Infection and Transformation....Pages 44-60
CtBP Proteins in Vertebrate Development....Pages 61-67
CtBP as a Redox Sensor in Transcriptional Repression....Pages 68-76
CtBP Corepressor Complex....Pages 77-82
Structural Determinants of CtBP Function....Pages 83-92
CtBP 3/BARS and Membrane Fission....Pages 93-104
CtBPs as Synaptic Proteins....Pages 105-111
A New Member of the CtBP/BARS....Pages 112-118
Back Matter....Pages 119-121
This book is a comprehensive monograph on the CtBP family proteins. These proteins are gaining wide scientific interest due to their critical roles in animal development and in oncogenesis. The CtBP family proteins are multifunctional. They predominantly function as transcriptional corepressors in the nucleus by recruiting various histone modifying enzymes such as histone deacetylases, histone methylases and a histone demethylase. They also perform several diverse cytosolic functions such as Golgi maintenance and in central nervous system synapses.
Content:
Front Matter....Pages i-ix
CtBP Family Proteins....Pages 1-17
Transcriptional Repression by the CtBP Corepressor in Drosophila ....Pages 18-27
CtBP and Hematopoietic Transcriptional Regulators....Pages 28-38
CtBP....Pages 39-43
The Significance of the CtBP — AdE1A Interaction during Viral Infection and Transformation....Pages 44-60
CtBP Proteins in Vertebrate Development....Pages 61-67
CtBP as a Redox Sensor in Transcriptional Repression....Pages 68-76
CtBP Corepressor Complex....Pages 77-82
Structural Determinants of CtBP Function....Pages 83-92
CtBP 3/BARS and Membrane Fission....Pages 93-104
CtBPs as Synaptic Proteins....Pages 105-111
A New Member of the CtBP/BARS....Pages 112-118
Back Matter....Pages 119-121
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