Ebook: Poly(ADP-Ribosyl)ation
Author: Alexander Bürkle M.D. (auth.)
- Tags: Medical Microbiology, Human Genetics, Biochemistry general, Cell Biology
- Series: Molecular Biology Intelligence Unit
- Year: 2006
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter.
Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter.
This book provides the most comprehensive and up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage (stroke, myocardial infarction), Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions.
Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter.
This book provides the most comprehensive and up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage (stroke, myocardial infarction), Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions.
Content:
Front Matter....Pages i-xvii
Enzymes in Poly(ADP-Ribose) Metabolism....Pages 1-12
PARP-2: Structure-Function Relationship....Pages 13-31
Targeting the Poly (ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals....Pages 32-40
DNA Damage Signaling through Poly(ADP-Ribose)....Pages 41-50
Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity....Pages 51-60
Functional Interactions of PARP-1 with p53....Pages 61-66
Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1 ....Pages 67-74
PARP-1 as Novel Coactivator of NF-?B in Inflammatory Disorders....Pages 75-90
PARP and Epigenetic Regulation....Pages 91-102
PARP and the Release of Apoptosis-Inducing Factor from Mitochondria....Pages 103-117
Genome Degradation by DNAS1L3 Endonuclease....Pages 118-131
NAD: Metabolism and Regulatory Functions....Pages 132-140
PARP-1 and the Shape of Cell Death....Pages 141-152
Poly(ADP-Ribose) Polymerase (PARP) and Excitotoxicity....Pages 153-163
Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusion Injury....Pages 164-183
Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock....Pages 184-202
Role of Poly-ADP-Ribosylation in Cancer Development....Pages 203-217
PARP Inhibitors and Cancer Therapy....Pages 218-233
Poly(ADP-Ribosyl)ation and Aging....Pages 234-241
Back Matter....Pages 243-246
Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter.
This book provides the most comprehensive and up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage (stroke, myocardial infarction), Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions.
Content:
Front Matter....Pages i-xvii
Enzymes in Poly(ADP-Ribose) Metabolism....Pages 1-12
PARP-2: Structure-Function Relationship....Pages 13-31
Targeting the Poly (ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals....Pages 32-40
DNA Damage Signaling through Poly(ADP-Ribose)....Pages 41-50
Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity....Pages 51-60
Functional Interactions of PARP-1 with p53....Pages 61-66
Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1 ....Pages 67-74
PARP-1 as Novel Coactivator of NF-?B in Inflammatory Disorders....Pages 75-90
PARP and Epigenetic Regulation....Pages 91-102
PARP and the Release of Apoptosis-Inducing Factor from Mitochondria....Pages 103-117
Genome Degradation by DNAS1L3 Endonuclease....Pages 118-131
NAD: Metabolism and Regulatory Functions....Pages 132-140
PARP-1 and the Shape of Cell Death....Pages 141-152
Poly(ADP-Ribose) Polymerase (PARP) and Excitotoxicity....Pages 153-163
Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusion Injury....Pages 164-183
Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock....Pages 184-202
Role of Poly-ADP-Ribosylation in Cancer Development....Pages 203-217
PARP Inhibitors and Cancer Therapy....Pages 218-233
Poly(ADP-Ribosyl)ation and Aging....Pages 234-241
Back Matter....Pages 243-246
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