Ebook: Endosomes
Author: Ivan Dikic M.D. Ph.D. (auth.)
- Tags: Cell Biology, Biochemistry general, Molecular Medicine
- Series: Molecular Biology Intelligence Unit
- Year: 2006
- Publisher: Springer-Verlag New York
- Edition: 1
- Language: English
- pdf
Endosomes are a heterogeneous population of endocytic vesicles and tubules that have captivated the interest of biologists for many years, partly due to their important cellular functions and partly due to their intriguing nature and dynamics. Endosomes represent a fascinating interconnected network of thousands of vesicles that transport various cargoes, mainly proteins and lipids, to distant cellular destinations. How endosomes function, what co-ordinates the molecular determinants at each step of their dynamic life cycle and what their biological and medical relevance is, are among the questions addressed in this book.
Endosomes are a heterogeneous population of endocytic vesicles and tubules that have captivated the interest of biologists for many years, partly due to their important cellular functions and partly due to their intriguing nature and dynamics. Endosomes represent a fascinating interconnected network of thousands of vesicles that transport various cargoes, mainly proteins and lipids, to distant cellular destinations. How endosomes function, what co-ordinates the molecular determinants at each step of their dynamic life cycle and what their biological and medical relevance is, are among the questions addressed in this book.
Endosomes are a heterogeneous population of endocytic vesicles and tubules that have captivated the interest of biologists for many years, partly due to their important cellular functions and partly due to their intriguing nature and dynamics. Endosomes represent a fascinating interconnected network of thousands of vesicles that transport various cargoes, mainly proteins and lipids, to distant cellular destinations. How endosomes function, what co-ordinates the molecular determinants at each step of their dynamic life cycle and what their biological and medical relevance is, are among the questions addressed in this book.
Content:
Front Matter....Pages i-xi
Endosomes Come of Age....Pages 1-13
Lipid Membrane Domains in Endosomes....Pages 14-22
Rab Domains on Endosomes....Pages 23-35
Synaptic Endosomes....Pages 36-49
Endosome Fusion....Pages 50-61
Clathrin Adaptor Proteins in Cargo Endocytosis....Pages 62-75
Protein Sorting in Endosomes....Pages 76-88
Signaling from Internalized Receptors....Pages 89-100
Endocytosis of Receptor Tyrosine Kinases....Pages 101-118
Endocytic Trafficking and Human Diseases....Pages 119-131
Endosomes—Key Components in Viral Entry and Replication....Pages 132-144
Toxins in the Endosomes....Pages 145-152
Back Matter....Pages 153-157
Endosomes are a heterogeneous population of endocytic vesicles and tubules that have captivated the interest of biologists for many years, partly due to their important cellular functions and partly due to their intriguing nature and dynamics. Endosomes represent a fascinating interconnected network of thousands of vesicles that transport various cargoes, mainly proteins and lipids, to distant cellular destinations. How endosomes function, what co-ordinates the molecular determinants at each step of their dynamic life cycle and what their biological and medical relevance is, are among the questions addressed in this book.
Content:
Front Matter....Pages i-xi
Endosomes Come of Age....Pages 1-13
Lipid Membrane Domains in Endosomes....Pages 14-22
Rab Domains on Endosomes....Pages 23-35
Synaptic Endosomes....Pages 36-49
Endosome Fusion....Pages 50-61
Clathrin Adaptor Proteins in Cargo Endocytosis....Pages 62-75
Protein Sorting in Endosomes....Pages 76-88
Signaling from Internalized Receptors....Pages 89-100
Endocytosis of Receptor Tyrosine Kinases....Pages 101-118
Endocytic Trafficking and Human Diseases....Pages 119-131
Endosomes—Key Components in Viral Entry and Replication....Pages 132-144
Toxins in the Endosomes....Pages 145-152
Back Matter....Pages 153-157
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