Ebook: Complement and Kidney Disease
- Tags: Immunology, Cell Biology, Nephrology, Human Physiology, Internal Medicine, Medical Microbiology
- Series: Progress in Inflammation Research
- Year: 2006
- Publisher: Birkhäuser Basel
- Edition: 1
- Language: English
- pdf
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
Content:
Front Matter....Pages i-xvi
The complement system in renal diseases....Pages 1-18
Complement in renal transplantation....Pages 19-35
C1q and the glomerulonephritides: therapeutic approaches for the treatment of complement-mediated kidney diseases....Pages 37-47
Complement deficient mice as model systems for kidney diseases....Pages 49-63
Non-Shiga toxin-associated hemolytic uremic syndrome....Pages 65-83
Role of complement and Factor H in hemolytic uremic syndrome....Pages 85-109
Genetic testing in atypical HUS and the role of membrane cofactor protein (MCP; CD46) and Factor I....Pages 111-127
Towards a new classification of hemolytic uremic syndrome....Pages 129-148
Therapeutic strategies for atypical and recurrent hemolytic uremic syndromes (HUS)....Pages 149-163
Complement defects in children which result in kidney diseases: diagnosis and therapy....Pages 165-197
The role of complement in membranoproliferative glomerulonephritis....Pages 199-221
The experience of a patient advocacy group....Pages 223-231
Back Matter....Pages 233-238
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
Content:
Front Matter....Pages i-xvi
The complement system in renal diseases....Pages 1-18
Complement in renal transplantation....Pages 19-35
C1q and the glomerulonephritides: therapeutic approaches for the treatment of complement-mediated kidney diseases....Pages 37-47
Complement deficient mice as model systems for kidney diseases....Pages 49-63
Non-Shiga toxin-associated hemolytic uremic syndrome....Pages 65-83
Role of complement and Factor H in hemolytic uremic syndrome....Pages 85-109
Genetic testing in atypical HUS and the role of membrane cofactor protein (MCP; CD46) and Factor I....Pages 111-127
Towards a new classification of hemolytic uremic syndrome....Pages 129-148
Therapeutic strategies for atypical and recurrent hemolytic uremic syndromes (HUS)....Pages 149-163
Complement defects in children which result in kidney diseases: diagnosis and therapy....Pages 165-197
The role of complement in membranoproliferative glomerulonephritis....Pages 199-221
The experience of a patient advocacy group....Pages 223-231
Back Matter....Pages 233-238
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