Ebook: Small RNAs: Analysis and Regulatory Functions
Author: E. Gerhart H. Wagner Fabien Darfeuille (auth.) Dr. Wolfgang Nellen Dr. Christian Hammann (eds.)
- Tags: Biochemistry general, Cell Biology, Developmental Biology
- Series: Nucleic Acids and Molecular Biology 17
- Year: 2006
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
In recent years Molecular Biology has experienced an unprecedented revolution by the discovery of functional small RNAs. The number of cellular processes in which non-coding RNAs are involved is growing rapidly and include gene regulation on the transcriptional, post-transcriptional and translational level. To complicate matters, these processes seem to be strongly interconnected on the one hand, and diverse among different organisms on the other. This volume describes strategies for the discovery and validation of small RNAs and provides a snapshot of our current understanding of the different mechanisms triggered by small RNAs.
In recent years Molecular Biology has experienced an unprecedented revolution by the discovery of functional small RNAs. The number of cellular processes in which non-coding RNAs are involved is growing rapidly and include gene regulation on the transcriptional, post-transcriptional and translational level. To complicate matters, these processes seem to be strongly interconnected on the one hand, and diverse among different organisms on the other. This volume describes strategies for the discovery and validation of small RNAs and provides a snapshot of our current understanding of the different mechanisms triggered by small RNAs.
In recent years Molecular Biology has experienced an unprecedented revolution by the discovery of functional small RNAs. The number of cellular processes in which non-coding RNAs are involved is growing rapidly and include gene regulation on the transcriptional, post-transcriptional and translational level. To complicate matters, these processes seem to be strongly interconnected on the one hand, and diverse among different organisms on the other. This volume describes strategies for the discovery and validation of small RNAs and provides a snapshot of our current understanding of the different mechanisms triggered by small RNAs.
Content:
Front Matter....Pages I-XII
Small Regulatory RNAs in Bacteria....Pages 1-29
Small Nucleolar RNAs: Identification, Structure, and Function....Pages 31-56
A Computational Approach to Search for Non-Coding RNAs in Large Genomic Data....Pages 57-74
Experimental Strategies for the Identification and Validation of Target RNAs that Are Regulated by miRNAs....Pages 75-90
Protein Interactions with Double-Stranded RNA in Eukaryotic Cells....Pages 91-118
Transitive and Systemic RNA Silencing: Both Involving an RNA Amplification Mechanism?....Pages 119-139
RNA Interference and Antisense Mediated Gene Silencing....Pages 141-158
Epigenetic Silencing of Transposons in the Green Alga Chlamydomonas reinhardtii....Pages 159-178
RNA-Dependent Gene Silencing and Epigenetics in Animals....Pages 179-200
Potentials of a Ribozyme-Based Gene Discovery System....Pages 201-215
Back Matter....Pages 217-219
In recent years Molecular Biology has experienced an unprecedented revolution by the discovery of functional small RNAs. The number of cellular processes in which non-coding RNAs are involved is growing rapidly and include gene regulation on the transcriptional, post-transcriptional and translational level. To complicate matters, these processes seem to be strongly interconnected on the one hand, and diverse among different organisms on the other. This volume describes strategies for the discovery and validation of small RNAs and provides a snapshot of our current understanding of the different mechanisms triggered by small RNAs.
Content:
Front Matter....Pages I-XII
Small Regulatory RNAs in Bacteria....Pages 1-29
Small Nucleolar RNAs: Identification, Structure, and Function....Pages 31-56
A Computational Approach to Search for Non-Coding RNAs in Large Genomic Data....Pages 57-74
Experimental Strategies for the Identification and Validation of Target RNAs that Are Regulated by miRNAs....Pages 75-90
Protein Interactions with Double-Stranded RNA in Eukaryotic Cells....Pages 91-118
Transitive and Systemic RNA Silencing: Both Involving an RNA Amplification Mechanism?....Pages 119-139
RNA Interference and Antisense Mediated Gene Silencing....Pages 141-158
Epigenetic Silencing of Transposons in the Green Alga Chlamydomonas reinhardtii....Pages 159-178
RNA-Dependent Gene Silencing and Epigenetics in Animals....Pages 179-200
Potentials of a Ribozyme-Based Gene Discovery System....Pages 201-215
Back Matter....Pages 217-219
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