Ebook: The Histone Code and Beyond: New Approaches to Cancer Therapy
Author: S. Kubicek G. Schotta M. Lachner R. Sengupta (auth.) S. L. Berger O. Nakanishi B. Haendler (eds.)
- Tags: Biochemistry general, Cell Biology, Oncology
- Series: Ernst Schering Research Foundation Workshop 57
- Year: 2006
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
Content:
Front Matter....Pages I-XIV
The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development....Pages 1-27
Nucleosome Structure and Function....Pages 29-46
The Role of Snf2-Related Proteins in Cancer....Pages 47-59
Imitation Switch Complexes....Pages 61-87
How Is Epigenetic Information on Chromatin Inherited After DNA Replication?....Pages 89-96
Polycomb Silencing Mechanisms and Genomic Programming....Pages 97-113
CpG Island Methylation and Histone Modifications: Biology and Clinical Significance....Pages 115-126
Histone Post-Translational Modifications Regulate Transcription and Silent Chromatin in Saccharomyces cerevisiae....Pages 127-153
Histone Acetylation-Mediated Chromatin Compaction During Mouse Spermatogenesis....Pages 155-172
Role of Ubiquitin-Like Proteins in Transcriptional Regulation....Pages 173-192
Interplay of the SUMO and MAP Kinase Pathways....Pages 193-209
Back Matter....Pages 211-215
Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
Content:
Front Matter....Pages I-XIV
The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development....Pages 1-27
Nucleosome Structure and Function....Pages 29-46
The Role of Snf2-Related Proteins in Cancer....Pages 47-59
Imitation Switch Complexes....Pages 61-87
How Is Epigenetic Information on Chromatin Inherited After DNA Replication?....Pages 89-96
Polycomb Silencing Mechanisms and Genomic Programming....Pages 97-113
CpG Island Methylation and Histone Modifications: Biology and Clinical Significance....Pages 115-126
Histone Post-Translational Modifications Regulate Transcription and Silent Chromatin in Saccharomyces cerevisiae....Pages 127-153
Histone Acetylation-Mediated Chromatin Compaction During Mouse Spermatogenesis....Pages 155-172
Role of Ubiquitin-Like Proteins in Transcriptional Regulation....Pages 173-192
Interplay of the SUMO and MAP Kinase Pathways....Pages 193-209
Back Matter....Pages 211-215
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