Ebook: Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules
- Tags: Human Genetics, Medical Biochemistry, Immunology, Neurosciences, Biotechnology, Biochemistry general
- Series: Medical Intelligence Unit
- Year: 2006
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.
This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.
This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.
Content:
Front Matter....Pages i-xviii
Front Matter....Pages 1-1
The Many Faces of PNA....Pages 3-17
Modulation of Nucleic Acid Information Processing by PNAs....Pages 18-29
Targeted Gene Delivery....Pages 30-37
Imaging Gene Expression in the Brain with Peptide Nucleic Acid (PNA) Antisense Radiopharmaceuticals and Drug Targeting Technology....Pages 38-60
Receptor-Specific Targeting with Complementary Peptide Nucleic Acids Conjugated to Peptide Analogs and Radionuclides....Pages 61-88
Morpholinos and PNAs Compared....Pages 89-113
Chemistry of Locked Nucleic Acids (LNA)....Pages 114-132
Recent Applications of RNA Interference (RNAi) in Mammalian Systems....Pages 133-147
Front Matter....Pages 149-149
Peptide Nucleic Acids as Epigenetic Inhibitors of HIV-1....Pages 151-170
Therapeutic Uses of Peptide Nucleic Acids (PNA) in Oncology....Pages 171-180
PNAs as Novel Cancer Therapeutics....Pages 181-194
Medicinal Chemistry of Plasmid DNA with Peptide Nucleic Acids....Pages 195-211
Locked Nucleic Acids (LNA) and Medical Applications....Pages 212-222
Peptide Nucleic Acids as Agents to Modify Target Gene Expression and Function....Pages 223-235
Peptide Nucleic Acids....Pages 236-242
The Use of PNAs and Their Derivatives in Mitochondrial Gene Therapy....Pages 243-251
Gene Silencing through RNA Interference....Pages 252-264
Transcriptional Activation of Human CREB Gene Promoter Using Bis-PNA (Peptide Nucleic Acid)....Pages 265-269
Back Matter....Pages 271-274
This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.
Content:
Front Matter....Pages i-xviii
Front Matter....Pages 1-1
The Many Faces of PNA....Pages 3-17
Modulation of Nucleic Acid Information Processing by PNAs....Pages 18-29
Targeted Gene Delivery....Pages 30-37
Imaging Gene Expression in the Brain with Peptide Nucleic Acid (PNA) Antisense Radiopharmaceuticals and Drug Targeting Technology....Pages 38-60
Receptor-Specific Targeting with Complementary Peptide Nucleic Acids Conjugated to Peptide Analogs and Radionuclides....Pages 61-88
Morpholinos and PNAs Compared....Pages 89-113
Chemistry of Locked Nucleic Acids (LNA)....Pages 114-132
Recent Applications of RNA Interference (RNAi) in Mammalian Systems....Pages 133-147
Front Matter....Pages 149-149
Peptide Nucleic Acids as Epigenetic Inhibitors of HIV-1....Pages 151-170
Therapeutic Uses of Peptide Nucleic Acids (PNA) in Oncology....Pages 171-180
PNAs as Novel Cancer Therapeutics....Pages 181-194
Medicinal Chemistry of Plasmid DNA with Peptide Nucleic Acids....Pages 195-211
Locked Nucleic Acids (LNA) and Medical Applications....Pages 212-222
Peptide Nucleic Acids as Agents to Modify Target Gene Expression and Function....Pages 223-235
Peptide Nucleic Acids....Pages 236-242
The Use of PNAs and Their Derivatives in Mitochondrial Gene Therapy....Pages 243-251
Gene Silencing through RNA Interference....Pages 252-264
Transcriptional Activation of Human CREB Gene Promoter Using Bis-PNA (Peptide Nucleic Acid)....Pages 265-269
Back Matter....Pages 271-274
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