Ebook: Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research

Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research presents current state-of-the-art findings relevant to cellular and molecular functions of polyamines, as well as providing the underlying conceptual basis and knowledge regarding potential therapeutic-targeting polyamines and polyamine metabolism leading to the development of new therapeutic approaches for cancers and other diseases. Divided into four main parts that include polyamines in signal transduction of cell proliferation; polyamines in cellular signaling of apoptosis, carcinogenesis, and cancer therapy; polyamines in cell motility and cell-cell interactions; and polyamine homeostasis and transport, these topics are addressed by internationally recognized experts in their respective fields.
This timely guide provides the whole picture of polyamines-past, present, and potential future, and offers a wealth of information regarding basic knowledge and current progress on cellular functions of polyamines and their potential clinical applications in cancer therapy. For investigators in the fields of polyamines, physiology, pharmacology, and cancer research, Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research serves as a foundation based on research and addresses the potential for subsequent applications in clinical practice.

---

Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research presents current state-of-the-art findings relevant to cellular and molecular functions of polyamines, as well as providing the underlying conceptual basis and knowledge regarding potential therapeutic-targeting polyamines and polyamine metabolism leading to the development of new therapeutic approaches for cancers and other diseases. Divided into four main parts that include polyamines in signal transduction of cell proliferation; polyamines in cellular signaling of apoptosis, carcinogenesis, and cancer therapy; polyamines in cell motility and cell-cell interactions; and polyamine homeostasis and transport, these topics are addressed by internationally recognized experts in their respective fields.
This timely guide provides the whole picture of polyamines-past, present, and potential future, and offers a wealth of information regarding basic knowledge and current progress on cellular functions of polyamines and their potential clinical applications in cancer therapy. For investigators in the fields of polyamines, physiology, pharmacology, and cancer research, Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research serves as a foundation based on research and addresses the potential for subsequent applications in clinical practice.

---

Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research presents current state-of-the-art findings relevant to cellular and molecular functions of polyamines, as well as providing the underlying conceptual basis and knowledge regarding potential therapeutic-targeting polyamines and polyamine metabolism leading to the development of new therapeutic approaches for cancers and other diseases. Divided into four main parts that include polyamines in signal transduction of cell proliferation; polyamines in cellular signaling of apoptosis, carcinogenesis, and cancer therapy; polyamines in cell motility and cell-cell interactions; and polyamine homeostasis and transport, these topics are addressed by internationally recognized experts in their respective fields.
This timely guide provides the whole picture of polyamines-past, present, and potential future, and offers a wealth of information regarding basic knowledge and current progress on cellular functions of polyamines and their potential clinical applications in cancer therapy. For investigators in the fields of polyamines, physiology, pharmacology, and cancer research, Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research serves as a foundation based on research and addresses the potential for subsequent applications in clinical practice.
Content:
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Polyamine Structure and Synthetic Analogs....Pages 3-24
Acute Increases in Intracellular Putrescine Lead to the Increase in Steady-State Levels of c-fos, c-jun, RING3, and Id-1 mRNAs....Pages 25-40
Polyamine-Dependent Early Cellular Signals and Cell Proliferation....Pages 41-50
Cellular Signals Mediating Growth Arrest After Polyamine Depletion....Pages 51-73
Role of Polyamines in the Regulation of Chromatin Acetylation....Pages 75-89
Role of Polyamines in Regulation of Sequence-Specific DNA Binding Activity....Pages 91-122
Polyamine Metabolism and the Hypertrophic Heart....Pages 123-137
Influence of Polyamines on Breast Cancer Biology....Pages 139-153
Polyamines in Regulation of Prostatic Cell Growth....Pages 155-168
Polyamines in Kidney Biology....Pages 169-186
Polyamines in Pulmonary Vascular Biology....Pages 187-202
Front Matter....Pages 203-203
Recent Advances in the Understanding of Mammalian Polyamine Catabolism....Pages 205-232
Cellular Signaling and Polyamines in the Control of Apoptosis in Intestinal Epithelial Cells....Pages 233-248
The Role of Ornithine Decarboxylase in Myc-Induced Tumorigenesis....Pages 249-266
Protective Effect of Polyamines on NSAID-Induced Injury and Apoptosis....Pages 267-278
Role of Polyamines in the Control of the Immune Response in the Brain....Pages 279-292
Implication of Polyamines in Apoptosis of Immunoresponse Cells....Pages 293-312
Polyamines and Cancer....Pages 313-328
Polyamine Pools and Cancer Prevention....Pages 329-346
Front Matter....Pages 347-347
Polyamines and Cytoskeletal Regulation During Intestinal Epithelial Restitution....Pages 349-362
Front Matter....Pages 347-347
Regulation of Kv Channel Activity and Intercellular Junctions by Polyamines in Intestinal Epithelial Cells....Pages 363-382
Polyamine Block of Kir Channels....Pages 383-396
Front Matter....Pages 397-397
Regulation of Ornithine Decarboxylase Expression....Pages 399-414
Evidence for a Multistep Model for Eukaryotic Polyamine Transport....Pages 415-432
Bacterial and Eukaryotic Transport Systems....Pages 433-448
Regulation of S-Adenosylmethionine Decarboxylase....Pages 449-464
Genetic Engineering of Polyamine Catabolism in Transgenic Mice and Rats....Pages 465-477
Back Matter....Pages 479-490

---

Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research presents current state-of-the-art findings relevant to cellular and molecular functions of polyamines, as well as providing the underlying conceptual basis and knowledge regarding potential therapeutic-targeting polyamines and polyamine metabolism leading to the development of new therapeutic approaches for cancers and other diseases. Divided into four main parts that include polyamines in signal transduction of cell proliferation; polyamines in cellular signaling of apoptosis, carcinogenesis, and cancer therapy; polyamines in cell motility and cell-cell interactions; and polyamine homeostasis and transport, these topics are addressed by internationally recognized experts in their respective fields.
This timely guide provides the whole picture of polyamines-past, present, and potential future, and offers a wealth of information regarding basic knowledge and current progress on cellular functions of polyamines and their potential clinical applications in cancer therapy. For investigators in the fields of polyamines, physiology, pharmacology, and cancer research, Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research serves as a foundation based on research and addresses the potential for subsequent applications in clinical practice.
Content:
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Polyamine Structure and Synthetic Analogs....Pages 3-24
Acute Increases in Intracellular Putrescine Lead to the Increase in Steady-State Levels of c-fos, c-jun, RING3, and Id-1 mRNAs....Pages 25-40
Polyamine-Dependent Early Cellular Signals and Cell Proliferation....Pages 41-50
Cellular Signals Mediating Growth Arrest After Polyamine Depletion....Pages 51-73
Role of Polyamines in the Regulation of Chromatin Acetylation....Pages 75-89
Role of Polyamines in Regulation of Sequence-Specific DNA Binding Activity....Pages 91-122
Polyamine Metabolism and the Hypertrophic Heart....Pages 123-137
Influence of Polyamines on Breast Cancer Biology....Pages 139-153
Polyamines in Regulation of Prostatic Cell Growth....Pages 155-168
Polyamines in Kidney Biology....Pages 169-186
Polyamines in Pulmonary Vascular Biology....Pages 187-202
Front Matter....Pages 203-203
Recent Advances in the Understanding of Mammalian Polyamine Catabolism....Pages 205-232
Cellular Signaling and Polyamines in the Control of Apoptosis in Intestinal Epithelial Cells....Pages 233-248
The Role of Ornithine Decarboxylase in Myc-Induced Tumorigenesis....Pages 249-266
Protective Effect of Polyamines on NSAID-Induced Injury and Apoptosis....Pages 267-278
Role of Polyamines in the Control of the Immune Response in the Brain....Pages 279-292
Implication of Polyamines in Apoptosis of Immunoresponse Cells....Pages 293-312
Polyamines and Cancer....Pages 313-328
Polyamine Pools and Cancer Prevention....Pages 329-346
Front Matter....Pages 347-347
Polyamines and Cytoskeletal Regulation During Intestinal Epithelial Restitution....Pages 349-362
Front Matter....Pages 347-347
Regulation of Kv Channel Activity and Intercellular Junctions by Polyamines in Intestinal Epithelial Cells....Pages 363-382
Polyamine Block of Kir Channels....Pages 383-396
Front Matter....Pages 397-397
Regulation of Ornithine Decarboxylase Expression....Pages 399-414
Evidence for a Multistep Model for Eukaryotic Polyamine Transport....Pages 415-432
Bacterial and Eukaryotic Transport Systems....Pages 433-448
Regulation of S-Adenosylmethionine Decarboxylase....Pages 449-464
Genetic Engineering of Polyamine Catabolism in Transgenic Mice and Rats....Pages 465-477
Back Matter....Pages 479-490
....