Ebook: Lymphocyte Trafficking in Health and Disease
- Tags: Immunology, Cell Biology, Hematology, Internal Medicine
- Series: Progress in Inflammation Research
- Year: 2006
- Publisher: Birkhäuser Basel
- Edition: 1
- Language: English
- pdf
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Content:
Front Matter....Pages i-x
Lymphocyte trafficking: from immunology paradigms to disease mechanisms....Pages 1-3
Front Matter....Pages 5-5
Biology of chemokines....Pages 7-38
Lymphocyte-endothelial cell interaction....Pages 39-54
Chemokine receptor expression in effector and memory T cell subsets....Pages 55-70
Migration of dendritic cell subsets....Pages 71-93
Migration of NK cells....Pages 95-112
Front Matter....Pages 113-113
Lymphocyte trafficking and chemokine receptors during pulmonary disease....Pages 115-131
Lymphocyte migration to the brain....Pages 133-149
Lymphocyte migration to the kidney....Pages 151-165
Leukocyte migration to pancreatic islets: a critical step in the pathogenesis of type 1 diabetes....Pages 167-179
Controlling leukocyte trafficking in disease....Pages 181-196
Front Matter....Pages 197-197
Leukocyte adhesion deficiency....Pages 199-210
Wiskott-Aldrich syndrome as a model of cytoskeleton defects....Pages 211-231
From CXCR4 mutations to WHIM syndrome....Pages 233-242
Back Matter....Pages 243-249
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Content:
Front Matter....Pages i-x
Lymphocyte trafficking: from immunology paradigms to disease mechanisms....Pages 1-3
Front Matter....Pages 5-5
Biology of chemokines....Pages 7-38
Lymphocyte-endothelial cell interaction....Pages 39-54
Chemokine receptor expression in effector and memory T cell subsets....Pages 55-70
Migration of dendritic cell subsets....Pages 71-93
Migration of NK cells....Pages 95-112
Front Matter....Pages 113-113
Lymphocyte trafficking and chemokine receptors during pulmonary disease....Pages 115-131
Lymphocyte migration to the brain....Pages 133-149
Lymphocyte migration to the kidney....Pages 151-165
Leukocyte migration to pancreatic islets: a critical step in the pathogenesis of type 1 diabetes....Pages 167-179
Controlling leukocyte trafficking in disease....Pages 181-196
Front Matter....Pages 197-197
Leukocyte adhesion deficiency....Pages 199-210
Wiskott-Aldrich syndrome as a model of cytoskeleton defects....Pages 211-231
From CXCR4 mutations to WHIM syndrome....Pages 233-242
Back Matter....Pages 243-249
....